Výsledky vyhledávání - "Cholesterol lowering drugs"

Akademický článek

Differential associations of statin treatment and polymorphism in genes coding for HMGCR and PCSK9 to risk for insomnia

Autor: Ahmed M. Alsehli, Gull Rukh, Laura E. Clemensson, Diana-Maria Ciuculete, Xiao Tan, Mohamed H. Al-Sabri, Michael J. Williams, Christian Benedict, Helgi B. Schiöth

Publikováno v: Frontiers in Bioscience-Landmark, Vol 26, Iss 12, Pp 1453-1463 (2021)

Importance: Statins have been linked to an increased risk for insomnia, but the literature is controversial. Moreover, it is unknown, if the potential effects are directly related to the inhibition of the statin target HMGCR, the subsequently lowered

Externí odkaz: https://doaj.org/article/bfe6d94443364285abc89ac22e3862c3

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Akademický článek

Cholesterol-Lowering Drugs as Potential Antivirals: A Repurposing Approach against Flavivirus Infections

Autor: Juan Fidel Osuna-Ramos, Carlos Noe Farfan-Morales, Carlos Daniel Cordero-Rivera, Luis Adrián De Jesús-González, José Manuel Reyes-Ruiz, Arianna M. Hurtado-Monzón, Selvin Noé Palacios-Rápalo, Ricardo Jiménez-Camacho, Marco Antonio Meraz-Ríos, Rosa María Del Ángel

Publikováno v: Viruses, Vol 15, Iss 7, p 1465 (2023)

Flaviviruses, including Dengue (DENV), Zika (ZIKV), and Yellow Fever (YFV) viruses, represent a significant global health burden. The development of effective antiviral therapies against these viruses is crucial to mitigate their impact. This study i

Externí odkaz: https://doaj.org/article/b4bae0356b79459d86ed48e8792850b9

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Akademický článek

Editorial: Highlights in Lipids in Cardiovascular Disease: 2021

Autor: Chaymae Boucheniata, Nolwenn Tessier, Catherine Martel

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Externí odkaz: https://doaj.org/article/735887a070ee4161bfc597ca91edae63

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Akademický článek

Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis

Autor: Navneet Kumar, Chandi C. Mandal

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Cholesterol has been reported to be accumulated in cancer cells. The metabolic dysregulation of the cholesterol is associated with tumor development and progression. The cholesterol-lowering drugs have been found to be involved in the prevention and

Externí odkaz: https://doaj.org/article/12b581347adb4a749f18228915191807

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Akademický článek

PCSK9 Inhibitor causes a decrease in the level of oxidatively modified low-density lipoproteins in patients with coronary artery diseases

Autor: V Z Lankin, A K Tikhaze, M Viigimaa, I E Chazova

Publikováno v: Терапевтический архив, Vol 90, Iss 9, Pp 27-30 (2018)

Aim. We study the dynamics of oxidatively modified low-density lipoprotein (ox-LDL) content in blood plasma, as well as changes in the activity of key antioxidant enzymes such as Se-containing glutathione peroxidase (GSH-Px) Cu,Zn-superoxide dismutas

Externí odkaz: https://doaj.org/article/39f37e8cd9434e7681fea7e643c7149f

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Akademický článek

Polyunsaturated Fatty Acid Impact on Clinical Outcomes in Acute Coronary Syndrome Patients With Dyslipidemia: Subanalysis of HIJ‐PROPER

Autor: Hiroyuki Arashi, Junichi Yamaguchi, Erisa Kawada‐Watanabe, Ryo Koyanagi, Haruki Sekiguchi, Fumiaki Mori, Shoji Haruta, Yasuhiro Ishii, Satoshi Murasaki, Kazuhito Suzuki, Takao Yamauchi, Hiroshi Ogawa, Nobuhisa Hagiwara

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 16 (2019)

Background This study aimed to examine the impact of baseline eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio on clinical outcomes of patients with acute coronary syndrome. Methods and Results In the HIJ‐PROPER (Heart Institute of Japan

Externí odkaz: https://doaj.org/article/705e2bad611d4d51b828e2808fa8e5fd

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Akademický článek

Lipoprotein(a) Particle Production as a Determinant of Plasma Lipoprotein(a) Concentration Across Varying Apolipoprotein(a) Isoform Sizes and Background Cholesterol‐Lowering Therapy

Autor: Dick C. Chan, Gerald F. Watts, Blai Coll, Scott M. Wasserman, Santica M. Marcovina, P. Hugh R. Barrett

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 7 (2019)

Background Elevated lipoprotein(a) (Lp(a)), a low‐density lipoprotein‐like particle bound to the polymorphic apolipoprotein(a) (apo(a)), may be causal for cardiovascular disease. However, the metabolism of Lp(a) in humans is poorly understood. Me

Externí odkaz: https://doaj.org/article/b9bd3fdda74847149ae9300d8831bb55

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