Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Cholesterol Synthesis Inhibition"'
Autor:
Judy A. Westrick, Nicholas J. Peraino, Philip C. Smith, Zofia Duniec-Dmuchowski, John K. Fallon, Elizabeth A. Rondini, Thomas A. Kocarek, Liberta Cuko, Asmita Pant, Elizabeth M. Wilson
Publikováno v:
Drug Metabolism and Disposition. 49:706-717
The squalene synthase inhibitor squalestatin 1 (Squal1) is a potent and efficacious inducer of CYP2B expression in primary cultured rat hepatocytes and rat liver. To determine whether Squal1 is also an inducer of human CYP2B, the effects of Squal1 tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ba5648d20b2edd3de1a6452431113d
https://doi.org/10.1124/dmd.120.000341
https://doi.org/10.1124/dmd.120.000341
Autor:
Abeer F. Alharbi, Pamala A. Jacobson, James Fisher, Takuto Takahashi, Nathan Rubin, Angela R. Smith, Mark N. Kirstein
Publikováno v:
International Journal of Clinical Pharmacology and Therapeutics
Fungal CYP51A (14α-sterol demethylase) is the target of an azole antifungal, voriconazole (VCZ), which also partially inhibits human CYP51A1. Hepatotoxicity is a common adverse effect of azoles, which is reported to be caused by altered gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc604686fc8eda2958c4c1476d0e3ffe
http://europepmc.org/articles/PMC8561836
http://europepmc.org/articles/PMC8561836
Autor:
Jason Charish, Xinjue Qin, Nardos G. Tassew, Thomas Wälchli, Jinzhou Feng, Andrea J. Mothe, Philippe P. Monnier, Alireza P. Shabanzadeh, Paulo D Koeberle, Shuzo Sugita, Nahal Farhani
Publikováno v:
Neurobiology of Disease, Vol 150, Iss, Pp 105259-(2021)
Neuronal regeneration in the injured central nervous system is hampered by multiple extracellular proteins. These proteins exert their inhibitory action through interactions with receptors that are located in cholesterol rich compartments of the memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e751d72c3d5862f9afe3a7d155d03f80
https://pubmed.ncbi.nlm.nih.gov/33434618
https://pubmed.ncbi.nlm.nih.gov/33434618
Publikováno v:
International immunopharmacology. 88
Non-alcoholic fatty liver disease (NAFLD) is a progressive and chronic liver disease. No effective drug is currently approved for the treatment of NAFLD. Traditionally it is thought that pathogenesis of NAFLD develops from some imbalance in lipid con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4b1842e3a245474961095d7b514cb2
https://pubmed.ncbi.nlm.nih.gov/32827918
https://pubmed.ncbi.nlm.nih.gov/32827918
Autor:
Duan-Fang Liao, Min Zhang, Caiping Zhang, Qin-Hui Tuo, Jian-Xiong Chen, Hui-xian Yang, Shiyin Long, Ying Tian
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 500
The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum (ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol response element binding protein 2 (SREBP2), pro-protein convertase subtilis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a1f34b3b9d5d3dfe5d24e99518c736
https://pubmed.ncbi.nlm.nih.gov/31770510
https://pubmed.ncbi.nlm.nih.gov/31770510
Autor:
Alan S. Halim, Carlos A. Tristan, Jayne M. Stommel, Uma Shankavaram, A. Gesine Cauer, Eric Batchelor, Orieta Celiku, Diane M. Kambach, Qian Sun, Aparna H. Kesarwala
Publikováno v:
Oncotarget
// Diane M. Kambach 1 , Alan S. Halim 1 , A. Gesine Cauer 1 , Qian Sun 1 , Carlos A. Tristan 1 , Orieta Celiku 1 , Aparna H. Kesarwala 1 , Uma Shankavaram 1 , Eric Batchelor 2 , Jayne M. Stommel 1 1 Radiation Oncology Branch, National Cancer Institut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed5dc2f8c98d98ea620504e218037ee
http://europepmc.org/articles/PMC5362450
http://europepmc.org/articles/PMC5362450
Autor:
Bruno A. Paim, Gabriel G. Dorighello, Mônica Siqueira Ferreira, Samara Kiihl, Helena C. F. Oliveira, Rodrigo Ramos Catharino, Anibal E. Vercesi
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
Atherosclerosis has been associated with mitochondria dysfunction and damage. Our group demonstrated previously that hypercholesterolemic mice present increased mitochondrial reactive oxygen (mtROS) generation in several tissues and low NADPH/NADP+ r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e861592111f63bb730bbaf7d912ac7
https://doi.org/10.1155/2016/7843685
https://doi.org/10.1155/2016/7843685
Akademický článek
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Autor:
Bradley S. Moore, Jonathan R. Chekan
Publikováno v:
Biochemistry. 57(6)
A comparison of effects of two hypocholesterolemic drugs--mevinolin and glycyrrhizinic acid, on cholesterol and bile acid metabolism in cultured rabbit hepatocytes has been carried out. The following parameters have been determined: i) cholesterol sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400406ce171bc842a357020868c87aa6
https://pubmed.ncbi.nlm.nih.gov/29313351
https://pubmed.ncbi.nlm.nih.gov/29313351
Autor:
Massimo Franchini, Carlo Bonfanti, Nicoletta Riva, Nicola Mumoli, Matteo Nicola Dario Di Minno, Marta Bellesini, Roberta Lupoli, Silvia Sabatini, Francesco Dentali, Walter Ageno, Valentina Borretta, Fulvio Pomero
Publikováno v:
Haematologica.
Statins have several pleiotropic effects, beyond cholesterol synthesis inhibition, including anti-inflammatory and antithrombotic properties.[1][1] They have been shown to reduce the rate of venous thromboembolism (VTE), but whether this beneficial e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e829b9e4371af7a3040cb3ee765750
https://doi.org/10.3324/haematol.2015.127183
https://doi.org/10.3324/haematol.2015.127183