Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Cholesterol 7α-hydroxylase"'
Autor:
Jennifer K. Truong, Ashley L. Bennett, Caroline Klindt, Ajay C. Donepudi, Sudarshan R. Malla, Kimberly J. Pachura, Alex Zaufel, Tarek Moustafa, Paul A. Dawson, Saul J. Karpen
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 9, Pp 100261- (2022)
Cyp2c70 is the liver enzyme in rodents responsible for synthesis of the primary 6-hydroxylated muricholate bile acid (BA) species. Cyp2c70 KO mice are devoid of protective, hydrophilic muricholic acids, leading to a more human-like BA composition and
Externí odkaz:
https://doaj.org/article/c8b1893ec9fd4770aafc4f38f85d3bae
Publikováno v:
Nutrition & Food Science, 2019, Vol. 50, Issue 2, pp. 303-313.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/NFS-04-2019-0108
Autor:
Akira Honda, Teruo Miyazaki, Junichi Iwamoto, Takeshi Hirayama, Yukio Morishita, Tadakuni Monma, Hajime Ueda, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tadashi Ikegami
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 54-69 (2020)
The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs). Moreover, in hum
Externí odkaz:
https://doaj.org/article/b6ca2ce2cff4472a9322001da895e681
Autor:
Veronika Voronova, Victor Sokolov, Amani Al-Khaifi, Sara Straniero, Chanchal Kumar, Kirill Peskov, Gabriel Helmlinger, Mats Rudling, Bo Angelin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 149-170 (2020)
Background & Aims: Disturbances of the enterohepatic circulation of bile acids (BAs) are seen in a number of clinically important conditions, including metabolic disorders, hepatic impairment, diarrhea, and gallstone disease. To facilitate the explor
Externí odkaz:
https://doaj.org/article/018c0db56b184ba3b01bdf259b968933
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 22, Iss 9, Pp 1004-1009 (2019)
Objective(s): Prevalence of high-fat food consumption, such as fast foods is one of the major causes of hypercholesterolemia, which can lead to cardiovascular diseases. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and cytochrome P450 7A1 (
Externí odkaz:
https://doaj.org/article/3603d636f824482692871dceceebbd43
Autor:
Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58c0ac6db641c550d04c5a5c6ba5a1a
https://doi.org/10.1016/j.apsb.2021.07.021
https://doi.org/10.1016/j.apsb.2021.07.021
Publikováno v:
Journal of Advanced Research
Graphical abstract
Introduction Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic total cholesterol (TC) and total triglyceride (TG) accumulation. In our previous study, we found that rats treated with hyperoside became re
Introduction Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic total cholesterol (TC) and total triglyceride (TG) accumulation. In our previous study, we found that rats treated with hyperoside became re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2bd34a875a308c3012404fcb1667cc
https://doi.org/10.1016/j.jare.2021.06.001
https://doi.org/10.1016/j.jare.2021.06.001
Autor:
Michael Goedken, Grace L. Guo, Brian Buckley, Bo Kong, Anita M. Brinker, Rulaiha Elizabeth Taylor, Daniel Rizzolo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3847-3856 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption of lipids and lipid soluble vitamins, bile flow, and regulation of gut microbiome. There are over 30 different BA species known to exist in humans and mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3528a74d648335c5d6495523367f011
http://www.sciencedirect.com/science/article/pii/S2211383521001891
http://www.sciencedirect.com/science/article/pii/S2211383521001891