Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

Autor: Carsten Friis Rundsten, Torben Hansen, Ivan Brandslund, Marta Guindo-Martínez, Mitja I. Kurki, Jose C. Florez, Sílvia Bonàs-Guarch, Aaron Leong, Joanne B. Cole, Kumar Veerapen, Niels Grarup, Josep M. Mercader, Mark J. O'Connor, Allan Linneberg, Varinderpal Kaur, David Torrents, Philip Schroeder, Paula Cortes-Sánchez, Oluf Pedersen, Alicia Huerta-Chagoya

Publikováno v: O'Connor, M J, Schroeder, P, Huerta-Chagoya, A, Cortés-Sánchez, P, Bonàs-Guarch, S, Guindo-Martínez, M, Cole, J B, Kaur, V, Torrents, D, Veerapen, K, Grarup, N, Kurki, M, Rundsten, C F, Pedersen, O, Brandslund, I, Linneberg, A, Hansen, T, Leong, A, Florez, J C & Mercader, J M 2022, ' Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes ', Diabetes, vol. 71, no. 3, pp. 554-565 . https://doi.org/10.2337/db21-0545
Diabetes

Most genome-wide association studies (GWAS) of complex traits are performed using models with additive allelic effects. Hundreds of loci associated with type 2 diabetes have been identified using this approach. Additive models, however, can miss loci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db48eb07b0bc907f358504be55446e94
https://portal.findresearcher.sdu.dk/da/publications/828dd316-3d73-43bd-ad39-c4d38447ca63

The Effects of Statin Dose, Lipophilicity, and Combination of Statins plus Ezetimibe on Circulating Oxidized Low-Density Lipoprotein Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Autor: Andrey V. Susekov, Amirhossein Sahebkar, Luis E. Simental-Mendía, Tannaz Jamialahmadi, Suowen Xu, Željko Reiner, Raul D. Santos, Fatemeh Baratzadeh

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)

Background. Elevated plasma low-density lipoprotein cholesterol (LDL-C) is the main risk factor for atherosclerotic cardiovascular disease (ASCVD). Statins are the drugs of choice for decreasing LDL-C and are used for the prevention and management of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead0f1fb3009a241d38dee2622f5e591
https://pubmed.ncbi.nlm.nih.gov/34526854

Evidence For and Against Dietary Recommendations to Prevent Cardiovascular Disease.

Autor: Dildy, Theresa¹ tdildy@stlukeshealth.org

Publikováno v: Texas Heart Institute Journal. May2015, Vol. 42 Issue 3, p234-236. 3p.

Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes: a secondary analysis from a 1-year randomized controlled trial

Autor: João Filipe Raposo, Diana A. Santos, Inês R. Correia, Rogério T. Ribeiro, Andreia Matos, Megan Hetherington-Rauth, Luís B. Sardinha, João P. Magalhães, Manuel Bicho

Publikováno v: Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-11 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cardiovascular Diabetology

© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to t

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https://doi.org/10.1186/s12933-020-01136-y

Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials

Autor: Terje R. Pedersen, Gregory G. Schwartz, Andrew Tonkin, Anastasia Lesogor, Helen M. Colhoun, Christiane Drechsler, Florian Kronenberg, Peter Willeit, John Simes, Paul M. Ridker, Sotirios Tsimikas, Anders G. Olsson, Samia Mora, Paul J. Nestel, Christoph Wanner

Publikováno v: Willeit, P, Ridker, P M, Nestel, P J, Simes, J, Tonkin, A M, Pedersen, T R, Schwartz, G G, Olsson, A G, Colhoun, H M, Kronenberg, F, Drechsler, C, Wanner, C, Mora, S, Lesogor, A & Tsimikas, S 2018, ' Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events : individual patient-data meta-analysis of statin outcome trials ', The Lancet, vol. 392, no. 10155, pp. 1311-1320 . https://doi.org/10.1016/S0140-6736(18)31652-0

BACKGROUND: Elevated lipoprotein(a) is a genetic risk factor for cardiovascular disease in general population studies. However, its contribution to risk for cardiovascular events in patients with established cardiovascular disease or on statin therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ab7522f95edf8333f4c52f73e98b03
https://doi.org/10.1016/s0140-6736(18)31652-0