Zobrazeno 1 - 10
of 2 179
pro vyhledávání: '"Cholangiocyte"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7395-7410 (2024)
Cholangiocellular carcinoma (CCA) is the second most common primary liver cancer, with increasing incidence worldwide and inadequate therapeutic options. Intra- and extrahepatic bile ducts have distinctly different embryonic origins and developmental
Externí odkaz:
https://doaj.org/article/635db1b64ee44c9095f96373b7ccba71
Autor:
P. Kreiner, E. Eggenhofer, L. Schneider, C. Rejas, M. Goetz, N. Bogovic, S. M. Brunner, K. Evert, H. J. Schlitt, E. K. Geissler, H. Junger
Publikováno v:
Transplant International, Vol 37 (2024)
Biliary complications are still a major cause for morbidity and mortality after liver transplantation (LT). Ischemia/reperfusion injury (IRI) leads to disruption of the biliary epithelium. We introduce a novel model to study the effect of IRI on huma
Externí odkaz:
https://doaj.org/article/18e60a304db74bd69c9c31d6a0fcdeca
Autor:
Zhenguo Wang, Chen Xing, Luc J. W. van der Laan, Monique M. A. Verstegen, Bart Spee, Rosalinde Masereeuw
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Drug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. During the past decades, several agents have been identified with various postulated mechanisms of bile duct
Externí odkaz:
https://doaj.org/article/8d28353034a843c4be8fec25debc89e5
Publikováno v:
Transplant International, Vol 37 (2024)
Liver transplantation is the only curative option for many liver diseases that end up in liver failure, and cholangiopathy remains a challenging complication post-liver transplant, associated with significant morbidity and potential graft loss. The l
Externí odkaz:
https://doaj.org/article/6e3acaf433004f8d93fb6827223db17b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Idiopathic cholangiopathies are diseases that affect cholangiocytes, and they have unknown etiologies. Currently, orthotopic liver transplantation is the only treatment available for end-stage liver disease. Limited access to the bile duct makes it d
Externí odkaz:
https://doaj.org/article/5897ac63506f471fa4b9ba4bd8002200
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located adjacent to the portal vein. This differentiation process is driven by Notch signaling, which
Externí odkaz:
https://doaj.org/article/9c8896ea8dfb49fc861a4292036d8e1f
Autor:
Yidi Chen, Jie Chen, Chongtu Yang, Yuanan Wu, Hong Wei, Ting Duan, Zhen Zhang, Liling Long, Hanyu Jiang, Bin Song
Publikováno v:
Insights into Imaging, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Hepatocellular carcinoma (HCC) expressing cytokeratin (CK) 7 or CK19 has a cholangiocyte phenotype that stimulates HCC proliferation, metastasis, and sorafenib therapy resistance This study aims to noninvasively predict cholangioc
Externí odkaz:
https://doaj.org/article/afbcd18337e245b8af4c7ac32fdae5ad
Autor:
Jiaxian Chen, Shiwen Ma, Hui Yang, Xi Liang, Heng Yao, Beibei Guo, Deying Chen, Jing Jiang, Dongyan Shi, Jiaojiao Xin, Keke Ren, Xingping Zhou, Yun Li, Lei Geng, Jun Li
Publikováno v:
Bioactive Materials, Vol 26, Iss , Pp 452-464 (2023)
Developing functional ductal organoids (FDOs) is essential for liver regenerative medicine. We aimed to construct FDOs with biliary tree networks in rat decellularized liver scaffolds (DLSs) with primary cholangiocytes isolated from mouse bile ducts.
Externí odkaz:
https://doaj.org/article/869acd17462641f5b2041d3566572757
Autor:
Tian Lan, Yang Tai, Chong Zhao, Yang Xiao, Zhu Yang, Linhao Zhang, Can Gan, Wenting Dai, Huan Tong, Chengwei Tang, Zhiyin Huang, Jinhang Gao
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-13 (2023)
Abstract Background Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injury, verify the impacts
Externí odkaz:
https://doaj.org/article/8456981888d34eb5ac2a72d53a81c439
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 5, Pp 724-732 (2023)
Objective To explore the potential application of the intrahepatic cholangiocyte organoid (ICO) differentiation model to study liver development. Methods Combining CRISPR/Cas9 gene editing technology and ICO differentiation model, bulk RNA-seq data o
Externí odkaz:
https://doaj.org/article/bfd5f7659025407f98c82f1f3c091a17