Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Chokoh Genka"'
Autor:
Takeo Tanaami, Hideyuki Ishida, Hiroe Nakazawa, Hidetaka Seguchi, Yuki Hirota, William H. Barry, Toshie Kadono, Chokoh Genka
Publikováno v:
The Japanese Journal of Physiology. 55:81-91
Intracellular [Ca2+] ([Ca2+]i) was imaged in atrial and ventricular rat myocytes by means of a high-speed Nipkow confocal microscope. Atrial myocytes with an absent t-tubule system on 8-di- ANEPPS staining showed an initial rise in Ca2+ at the periph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f66794e754b890f85a1e83a5e036434
https://doi.org/10.2170/jjphysiol.r2077
https://doi.org/10.2170/jjphysiol.r2077
Autor:
Yuki Hirota, Haruaki Nakaya, Hiroe Nakazawa, Hideyuki Ishida, Toshiaki Sato, Chokoh Genka, Naoko Higashijima
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 369:192-197
The anti-anginal drug nicorandil has been demonstrated to protect the myocardium against ischemic injury in both experimental and clinical studies. Although nicorandil seems to protect the myocardium via activation of mitochondrial ATP-sensitive K+ (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d49e21245928102dddeb845a02c27db
https://doi.org/10.1007/s00210-003-0851-z
https://doi.org/10.1007/s00210-003-0851-z
Autor:
Tohru Sawada, Shunnosuke Handa, Yukihiro Koretsune, Yasuhisa Kitagawa, Yasuo Katayama, Hideo Kusuoka, Norio Tanahashi, Katsuya Nishimaru, Kempei Matsuoka, Motoo Tsushima, Chikuma Hamada, Chokoh Genka, Takenori Yamaguchi, Yasuo Ohashi, Shinichiro Uchiyama, Yukito Shinohara, Hiroko Yamamoto
Publikováno v:
Cerebrovascular diseases (Basel, Switzerland). 37(4)
Background: The Cilostazol Stroke Prevention Study 2 (CSPS 2) showed that cilostazol significantly reduced the risk of stroke by 25.7% relative to aspirin, with significantly fewer hemorrhagic events, in patients with prior ischemic stroke, excluding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e151b0dc58ce9438f6c24aec4d9d17
https://pubmed.ncbi.nlm.nih.gov/24820203
https://pubmed.ncbi.nlm.nih.gov/24820203
Publikováno v:
The Japanese Journal of Physiology. 49:479-484
Haloperidol (HPL), a widely used antipsychotic drug, is known to induce serious ventricular arrhythmias. However, the mechanism underlying their induction is not clear. We therefore examined the effects of HPL on the intracellular Ca(2+) ([Ca(2+)](i)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d4accf8bd4c78d5a29f0a165adb40d
https://doi.org/10.2170/jjphysiol.49.479
https://doi.org/10.2170/jjphysiol.49.479
Publikováno v:
Molecular and Cellular Biochemistry. 198:31-38
Myocardial stunning is characterized by the impairment of excitation-contraction coupling via a decrease in myofilament Ca2+ responsiveness, thought to be triggered by hydroxyl radicals (·OH) generated upon reperfusion. Since peroxynitrite is also e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29de5e2e86e3803dd3172d4dc1588045
https://doi.org/10.1023/a:1006989826711
https://doi.org/10.1023/a:1006989826711
Autor:
Yukito, Shinohara, Yasuo, Katayama, Shinichiro, Uchiyama, Takenori, Yamaguchi, Shunnosuke, Handa, Kempei, Matsuoka, Yasuo, Ohashi, Norio, Tanahashi, Hiroko, Yamamoto, Chokoh, Genka, Yasuhisa, Kitagawa, Hideo, Kusuoka, Katsuya, Nishimaru, Motoo, Tsushima, Yukihiro, Koretsune, Tohru, Sawada, Chikuma, Hamada, Kiyoshi, Yuki
Publikováno v:
The Lancet. Neurology. 9(10)
Summary Background The antiplatelet drug cilostazol is efficacious for prevention of stroke recurrence compared with placebo. We designed the second Cilostazol Stroke Prevention Study (CSPS 2) to establish non-inferiority of cilostazol versus aspirin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7051b97a40f70d3310e1a0732c9a5084
https://pubmed.ncbi.nlm.nih.gov/20833590
https://pubmed.ncbi.nlm.nih.gov/20833590
Publikováno v:
Circulation research. 89(10)
We tested whether opening of mitochondrial ATP-sensitive K + (mitoK ATP ) channels depolarizes mitochondrial membrane potential (ΔΨ m ) and thereby prevents the mitochondrial Ca 2+ overload. With the use of a Nipkow disk confocal system, the mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d1aef8b3dc4bddc5e207b7f4131340
https://pubmed.ncbi.nlm.nih.gov/11701611
https://pubmed.ncbi.nlm.nih.gov/11701611
Publikováno v:
The Japanese journal of physiology. 51(4)
We used authentic NO or NO from NO donors to show that the physiological levels of NO (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05333d45f03a312e65d38d5a172558aa
https://pubmed.ncbi.nlm.nih.gov/11564282
https://pubmed.ncbi.nlm.nih.gov/11564282
Publikováno v:
Cell calcium. 25(3)
In contracting cardiac myocytes, the rapid changes in cytosolic and nuclear Ca2+ make it difficult to determine whether the nuclear Ca2+ transient is caused by diffusion from the cytosol or by Ca2+ release channels on the inner nuclear membrane, or b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3153697627ae49aa72f01dd60348c6a0
https://pubmed.ncbi.nlm.nih.gov/10378081
https://pubmed.ncbi.nlm.nih.gov/10378081
A method to expose cultured cardiac myocytes to authentic ONOO− by using a constant perfusion system was described. The perfusion apparatus is linked to a microscope equipped with video and fluorescence measurement systems, which enable the evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e96ebd829c6123e6fda612a22f892c7
https://doi.org/10.1016/s0076-6879(99)01104-0
https://doi.org/10.1016/s0076-6879(99)01104-0
