Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Choi Lai Tiong"'
Autor:
Yuji Mishina, Jianling Wang, Choi-Lai Tiong-Yip, He Guo, Noel Marie-France Thomsen, Jill Nunez, Franco Lombardo, Clayton Springer, Jason Baird, L. Alex Gaither, John D. Norris, Sunkyu Kim, Brant Firestone, Stefan Peukert, Kaitlin J. Macchi, Donald P. McDonnell, Tinya Abrams, Chunrong Wang, Bing Yu, Lawrence G. Hamann, Yingchuan Sun, Burks Heather Elizabeth, Christina A. Kirby, George Scott Tria
Publikováno v:
Journal of Medicinal Chemistry. 61:2837-2864
In breast cancer, estrogen receptor alpha (ERα) positive cancer accounts for approximately 74% of all diagnoses, and in these settings, it is a primary driver of cell proliferation. Treatment of ERα positive breast cancer has long relied on endocri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281b788e18778a84f111fefb917205c1
https://doi.org/10.1021/acs.jmedchem.7b01682
https://doi.org/10.1021/acs.jmedchem.7b01682
Publikováno v:
Cancer Research. 79:4769-4769
Breast cancer is the most common cancer in women worldwide, and the second most common cause of cancer death in woman in the US. Close to 80% of breast cancer are estrogen receptor (ER) positive and can benefit from antiestrogen treatment. LSZ102 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4439e33158927d3b9099f6be7520bbc7
https://doi.org/10.1158/1538-7445.am2019-4769
https://doi.org/10.1158/1538-7445.am2019-4769
Autor:
Jinyun Chen, Sarat Chandarlapaty, Qing Sheng, Choi Lai Tiong Yip, Alice Loo, Tinya Abrams, Stefan Peukert, Weiyi Toy, Adam S. Crystal, L. Alex Gaither, Rita Das, Yuji Mishina, Chunrong Wang
Publikováno v:
Cancer Research. 79:922-922
Estrogen receptor (ER) blockade is a well-established therapeutic approach in ER+ breast cancer. A novel oral selective estrogen receptor degrader (SERD), LSZ102, is in development. LSZ102 induces proteasome-mediated degradation of both wild type and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07fff1068288a98f665ba82fe00d498e
https://doi.org/10.1158/1538-7445.am2019-922
https://doi.org/10.1158/1538-7445.am2019-922
Autor:
Choi Lai Tiong-Yip, SreeRupa Challa, Ning Gao, Andrew D. Scott, Ying Zhou, Olga Yuzhakov, Qin Yu, Jason Thresher
Publikováno v:
Antimicrobial agents and chemotherapy. 59(2)
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children and other high-risk populations. RSV nucleoprotein (N) is essential for virus assembly and replication as part of the viral ribonucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8ab654915dbaff7b4f0856c29e594a
https://pubmed.ncbi.nlm.nih.gov/25451060
https://pubmed.ncbi.nlm.nih.gov/25451060
Autor:
Asuncion Martinez, Kara Brown, Ian Macneil, Marcia S. Osburne, Choi Lai Tiong Yip, Joern Hopke, Steven J. Kolvek
Publikováno v:
Applied and Environmental Microbiology. 70:2452-2463
The enormous diversity of uncultured microorganisms in soil and other environments provides a potentially rich source of novel natural products, which is critically important for drug discovery efforts. Our investigators reported previously on the cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a219d53f5b54c86956b77eae542618
https://doi.org/10.1128/aem.70.4.2452-2463.2004
https://doi.org/10.1128/aem.70.4.2452-2463.2004
Autor:
Robert E. McLaughlin, Olga Yuzhakov, Qin Yu, Pamela Hill, Vincent M. Isabella, Ewan F. Dunn, Valerie A. Laganas, Choi Lai Tiong-Yip
Publikováno v:
Antiviral research. 115
Respiratory Syncytial Virus (RSV) is a major cause of lower respiratory tract infections with no effective treatment available. Finding novel inhibitors of RSV is an important first step towards developing an efficacious RSV therapy. Here we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f517e3acdbcdab31443ec2e9025090
https://pubmed.ncbi.nlm.nih.gov/25542974
https://pubmed.ncbi.nlm.nih.gov/25542974
Publikováno v:
Journal of biomolecular screening. 20(5)
Respiratory syncytial virus (RSV) infects 99% of children by age 2 years and is a leading cause of serious lower respiratory tract infection (LRTI) and infant hospitalization in the United Kingdom. Identification of efficacious RSV therapeutics has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f3d21f59d9d5fe95eff2690e94054e
https://pubmed.ncbi.nlm.nih.gov/25656237
https://pubmed.ncbi.nlm.nih.gov/25656237
Autor:
Choi-Lai Tiong-Yip, Kenneth D. Johnson, SreeRupa Challa, Robert E. McLaughlin, Jun Fan, Qin Yu, Hui Xiong, Lisa Aschenbrenner
Publikováno v:
Antimicrobial agents and chemotherapy. 58(7)
The respiratory syncytial virus (RSV) L protein is a viral RNA-dependent RNA polymerase that contains multiple enzyme activities required for RSV replication. The RSV L inhibitors described in literature are limited by their cytotoxicity or the lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a9f6c1f1f83b7af4c1f67df652e40b
https://pubmed.ncbi.nlm.nih.gov/24777090
https://pubmed.ncbi.nlm.nih.gov/24777090
Autor:
Kara A. Loiacono, Ian A. MacNeil, Berkley A. Lynch, Taylor Merry, Chi B. Vu, Ukti Mani, Vaibhav Varkhedkar, John L. Buchanan, Dennis A. Holt, Selvaluxmi G. Pradeepan, Hilary R. Plake, Michael Yang, Evelyn G. Corpuz, Choi Lai Tiong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2359-2364
The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4- and 2,5-substituted thiazoles and 1,2,4-oxadiazoles as scaffolds resulted in inhibitors th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e24c3271625ce90015f47df8c67738d
https://doi.org/10.1016/s0960-894x(99)00389-3
https://doi.org/10.1016/s0960-894x(99)00389-3
Publikováno v:
Analytical Biochemistry. 247:77-82
The tyrosine kinase pp60c-srchas been implicated as being a potential therapeutic target in several human diseases including cancer and osteoporosis. An important region within this kinase is the SH2 domain (Src homology 2) which binds to phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84affa1ba81b263b62e8e36801235d44
https://doi.org/10.1006/abio.1997.2042
https://doi.org/10.1006/abio.1997.2042