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Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.

Autor: Hughes, Craig¹ (AUTHOR), Choi, Minee L.^2,3 (AUTHOR), Yi, Jee-Hyun^4,5 (AUTHOR), Kim, Seung-Chan^4,6 (AUTHOR), Drews, Anna^1,7 (AUTHOR), George-Hyslop, Peter St.⁸ (AUTHOR), Bryant, Clare⁹ (AUTHOR), Gandhi, Sonia^2,3 (AUTHOR), Cho, Kwangwook^4,6 (AUTHOR), Klenerman, David^1,10 (AUTHOR) dk10012@cam.ac.uk

Publikováno v: Communications Biology. 12/1/2020, Vol. 3 Issue 1, p1-7. 7p.

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Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.

Autor: Choi, Minee L.^1,2, Gandhi, Sonia^1,2 sonia.gandhi@ucl.ac.uk

Publikováno v: FEBS Journal. Oct2018, Vol. 285 Issue 19, p3631-3644. 14p.

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

Autor: Ludtmann, Marthe HR, Angelova, Plamena R, Horrocks, Mathew H, Choi, Minee L, Rodrigues, Margarida, Baev, Artyom Y, Berezhnov, Alexey V, Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T, Whiten, Daniel R, Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J, Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V, Klenerman, David, Abramov, Andrey Y, Gandhi, Sonia

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Ludtmann, M HR, Angelova, P R, Horrocks, M H, Choi, M, Rodrigues, M, Baev, A Y, Berezhnov, A V, Yao, Z, Little, D, Banushi, B, Al-Menhali, A S, Ranasinghe, R T, Whiten, D R, Yapom, R, Singh Dolt, K, Devine, M J, Gissen, P, Kunath, T, Jaganjac, M, Pavlov, E V, Klenerman, D, Abramov, A Y & Gandhi, S 2018, ' α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease ', Nature Communications, vol. 9, 2293 . https://doi.org/10.1038/s41467-018-04422-2
Nature Communications

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP synthase efficiency. Here, we report that aggregation of monom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0b0da49f274033083306f195bd37f3
http://link.springer.com/article/10.1038/s41467-018-04422-2