Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Choh Yeung"'
Autor:
Christine M. Heske, Choh Yeung, Arnulfo Mendoza, Joshua T. Baumgart, Leah D. Edessa, Xiaolin Wan, Lee J. Helman
Publikováno v:
Translational Oncology, Vol 9, Iss 6, Pp 540-547 (2016)
To determine what alternative pathways may act as mechanisms of bypass resistance to type 1 insulin-like growth factor receptor (IGF-1R) blockade in rhabdomyosarcoma (RMS), we compared expression of receptor tyrosine kinase activity in a number of IG
Externí odkaz:
https://doaj.org/article/39d2044f41514d60baf91816e2983a9b
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 4, Pp 358-366 (2015)
The insulin-like growth factor 1 receptor (IGF-1R) has surfaced as a significant target in multiple solid cancers due to its fundamental roles in pro-survival and anti-apoptotic signaling. However, development of resistance to IGF-1R blockade represe
Externí odkaz:
https://doaj.org/article/a9fe48977a3d4667ad7cee19c5720db0
Autor:
Patrick J. Grohar, Laurie B. Griffin, Choh Yeung, Qing-Rong Chen, Yves Pommier, Chand Khanna, Javed Khan, Lee J. Helman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 2, Pp 145-153 (2011)
ET-743 (trabectedin; Yondelis) is approved in Europe for the treatment of soft tissue sarcomas. Emerging phase 1 and 2 clinical data have shown high response rates in myxoid liposarcoma in part owing to the inhibition of the FUS-CHOP transcription fa
Externí odkaz:
https://doaj.org/article/c86295400c35400d9d05c4b0475b6dff
Autor:
Lee J. Helman, Amy McCalla, Jhazeel O. Martinez Juarez, Joshua T. Baumgart, Choh Yeung, Katherine K. Slemmons
Primer sets used for qRT-PCR and MS-PCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8e3a184ffb618586d36d1446f97a8
https://doi.org/10.1158/0008-5472.22422936.v1
https://doi.org/10.1158/0008-5472.22422936.v1
Autor:
Christine M. Heske, Leonard M. Neckers, Victor Darley-Usmar, Matthew D. Hall, Murali C. Krishna, Gordon M. Stott, Lee J. Helman, Mioara Larion, Jack F. Shern, Arnulfo Mendoza, Adrian Lita, Victor Ruiz-Rodado, Tyrone Dowdy, John Hamre, Sandy Eldridge, Haiyan Lei, Marielle E. Yohe, Giuseppe L. Squadrito, Gloria A. Benavides, Michelle S. Johnson, Daniel J. Urban, Ganesha Rai, Leah D. Edessa, Joshua T. Baumgart, Nobu Oshima, Sameer H. Issaq, Anna E. Gibson, Choh Yeung
A description of additional supplemental methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a582cfc30e75e1f35dbfbe55d3f2fd
https://doi.org/10.1158/0008-5472.22422704
https://doi.org/10.1158/0008-5472.22422704
Autor:
Lee J. Helman, Arnulfo Mendoza, Maurizio D'Incalci, Yves Pommier, Choh Yeung, Laure E. Segars, Patrick J. Grohar
PDF file 74K, Growth curves showing mean tumor volume for cohorts of mice with the TC71 (top) and TC32 (bottom) xenografts for vehicle control (blue), trabectedin treatment (ET-743; Red), irinotecan (green) and trabectedin plus irinotecan (combinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04681535ed8b0b949ee55b29017e6ea4
https://doi.org/10.1158/1078-0432.22448823
https://doi.org/10.1158/1078-0432.22448823
Autor:
Lee J. Helman, Arnulfo Mendoza, Maurizio D'Incalci, Yves Pommier, Choh Yeung, Laure E. Segars, Patrick J. Grohar
Purpose: The goal of this study is to optimize the activity of trabectedin for Ewing sarcoma by developing a molecularly targeted combination therapy.Experimental Design: We have recently shown that trabectedin interferes with the activity of EWS-FLI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93b7c6e8b5e1024e6a5060ec0eacc26
https://doi.org/10.1158/1078-0432.c.6521493.v1
https://doi.org/10.1158/1078-0432.c.6521493.v1
Autor:
Christine M. Heske, Leonard M. Neckers, Victor Darley-Usmar, Matthew D. Hall, Murali C. Krishna, Gordon M. Stott, Lee J. Helman, Mioara Larion, Jack F. Shern, Arnulfo Mendoza, Adrian Lita, Victor Ruiz-Rodado, Tyrone Dowdy, John Hamre, Sandy Eldridge, Haiyan Lei, Marielle E. Yohe, Giuseppe L. Squadrito, Gloria A. Benavides, Michelle S. Johnson, Daniel J. Urban, Ganesha Rai, Leah D. Edessa, Joshua T. Baumgart, Nobu Oshima, Sameer H. Issaq, Anna E. Gibson, Choh Yeung
Combined Supplementary Data file containing: Figure S1. Proliferation assays using NCI-737 and NCI-006 in an expanded panel of EWS cell lines. Figure S2. Effects of additional siRNA sequences against LDHA and LDHB in an expanded panel of EWS cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26573147da0f2dbc8cbf264b62233f2b
https://doi.org/10.1158/0008-5472.22422707.v1
https://doi.org/10.1158/0008-5472.22422707.v1
Autor:
Lee J. Helman, Amy McCalla, Jhazeel O. Martinez Juarez, Joshua T. Baumgart, Choh Yeung, Katherine K. Slemmons
DNMTi treatment in additional RMS cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08aefdb3c4b4a76dab252b3567a0d862
https://doi.org/10.1158/0008-5472.22422954
https://doi.org/10.1158/0008-5472.22422954
Autor:
Lee J. Helman, Amy McCalla, Jhazeel O. Martinez Juarez, Joshua T. Baumgart, Choh Yeung, Katherine K. Slemmons
H&E pictures of Rh30 tumors in Figure 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0559f9f04b5f5c0df14fe098e4d6f3bb
https://doi.org/10.1158/0008-5472.22422939.v1
https://doi.org/10.1158/0008-5472.22422939.v1