Výsledky vyhledávání - "Choe, Joseph"

Engineering T Cells to Treat Cancer: The Convergence of Immuno-Oncology and Synthetic Biology

Autor: Jasper Z. Williams, Wendell A. Lim, Choe Joseph H

Publikováno v: Annual Review of Cancer Biology. 4:121-139

T cells engineered to recognize and kill tumor cells have emerged as powerful agents for combating cancer. Nonetheless, our ability to engineer T cells remains relatively primitive. Aside from CAR T cells for treating B cell malignancies, most T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d28ac0ce754c5c8557ed3f7a20dc2b3b
https://doi.org/10.1146/annurev-cancerbio-030419-033657

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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

Publikováno v: Science translational medicine, vol 13, iss 591
Sci Transl Med

Treatment of solid cancers with chimeric antigen receptor (CAR) T cells is plagued by the lack of ideal target antigens that are both absolutely tumor specific and homogeneously expressed. We show that multi-antigen prime-and-kill recognition circuit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b526cc204fad3a7a0516aa6cc3ee6df1
https://escholarship.org/uc/item/64p7w6f3

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Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma

Autor: Wendell A. Lim, Milos S. Simic, Kira M. Downey, Aileen W. Li, Jessica D. Briones, Anna Celli, Nira A. Krasnow, Wei Yu, Choe Joseph H, Lia Cardarelli, Payal Watchmaker, Kole T. Roybal, Diego A. Carrera, Sachdev S. Sidhu, Ryan Gilbert, Juhyun Cho, Hideho Okada, Ruth Dannenfelser

Treatment of solid cancers with chimeric antigen receptor (CAR) T cells is plagued by the lack of target antigens that are both tumor-specific and homogeneously expressed. We show that multiantigen prime-and-kill recognition circuits have the flexibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18183e53b5f300c0e5f0cfd4adf01ba7
https://doi.org/10.1101/2021.01.07.425632

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IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA

Autor: Anna Celli, Nira A. Krasnow, Kira Downey, Jessica D. Briones, Wendell A. Lim, Sachdev S. Sidhu, Aileen li, Choe Joseph H, Wei Yu, Milos S. Simic, Ruth Dannenfelser, Hideho Okada, Lia Cardarelli, Payal Watchmaker, Diego Carrera, Juhyun Cho, Kole T. Roybal, Ryan Gilbert

Publikováno v: Neuro Oncol

Treatment of solid cancers with chimeric antigen receptor (CAR) T-cells is challenging because of a lack of target antigens that are both tumor-specific and homogenously expressed. While epidermal growth factor receptor (EGFR)vIII represents a gliobl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc545364e712760df0b9976a391572a
https://doi.org/10.1093/neuonc/noaa215.463

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Synthetic Biology Approach to Engineering T cells to Treat Cancer

Autor: Choe, Joseph Harim

Publikováno v: Choe, Joseph Harim. (2019). Synthetic Biology Approach to Engineering T cells to Treat Cancer. UC San Francisco: Biochemistry and Molecular Biology. Retrieved from: http://www.escholarship.org/uc/item/8qf421gd

Cell-based therapeutics have become a powerful method to combat cancer. Unlike small-molecule drugs or biologics, cells are able to integrate multiple inputs to execute complex response behaviors. Although cell-based therapies are poised to revolutio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::a30e4e504403ebd271a7c594cc9c806c
http://www.escholarship.org/uc/item/8qf421gd

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IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION

Autor: Hideho Okada, Wendell A. Lim, Kira Downey, Payal Watchmaker, Kole T. Roybal, Wei Yu, Ryan Gilbert, Diego Carrera, Choe Joseph H

Publikováno v: Neuro Oncol

Heterogeneous expression of target antigens allows tumor escape from chimeric antigen receptor-transduced T-cell (CART) therapy targeting a single antigen. While epidermal growth factor receptor (EGFR)vIII represents a glioblastoma (GBM)-specific ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8061ca3fb556ce969e77c0b402e0f356
https://doi.org/10.1093/neuonc/noz175.514

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