Výsledky vyhledávání - "Chodakewitz Jeffrey A"

The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol

Publikováno v: Journal of Psychopharmacology, 26, 2, pp. 292-302
Journal of Psychopharmacology, 26(2), 292-302
Journal of Psychopharmacology, 26, 292-302

Item does not contain fulltext Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1fbad04db88a008450901c8347b622
https://hdl.handle.net/2066/109808

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Pharmacokinetics, Safety, and Tolerability of Phentermine in Healthy Participants Receiving Taranabant, a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist

Autor: John A. Wagner, Kimberly Rosko, Hankun Li, Chodakewitz Jeffrey A, Carol Addy, Susie Li, Andrea Maes, Amy O. Johnson-Levonas, Patricia Jumes, S. Aubrey Stoch

Publikováno v: The Journal of Clinical Pharmacology. 49:1228-1238

This study assessed the potential pharmacokinetic interaction and safety/tolerability of taranabant and phentermine coadministration. This was a randomized, double-blind, 3-panel, fixed-sequence study in healthy participants. Panels A, B, and C evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e393a7f851ae7e6447bd1e84d86343bb
https://doi.org/10.1177/0091270009341651

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Effect of Different Durations of Ketoconazole Dosing on the Single-Dose Pharmacokinetics of Midazolam: Shortening the Paradigm

Autor: M. Fitzgerald, Evan J. Friedman, Chodakewitz Jeffrey A, John A. Wagner, Ka Lai Yee, S. A. Stoch, Yan Xu, Andrea Maes, Patrick Larson

Publikováno v: The Journal of Clinical Pharmacology. 49:398-406

Given the prominent role of cytochrome P450 3A (CYP3A) in the metabolism of drugs, it is critical to determine whether new chemical entities will be affected by the inhibition of this enzyme system and result in clinically relevant drug interactions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e57153f3e836b4c02bac722475dd94
https://doi.org/10.1177/0091270008331133

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A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less

Autor: Chodakewitz Jeffrey A, Henry H. Balfour, Margaret A. Fischl, Joseph J. Eron, Jon C. Cook, Lawrence Deyton, Kathleen Squires, John P. Phair, Michael Hughes, Judith Feinberg, Scott M. Hammer, Louise Pedneault, Janet M. Grimes, Judith S. Currier, Lisa M. Demeter, Bach-Yen Nguyen, William Spreen

Publikováno v: New England Journal of Medicine. 337:725-733

Background The efficacy and safety of adding a protease inhibitor to two nucleoside analogues to treat human immunodeficiency virus type 1 (HIV-1) infection are not clear. We compared treatment with the protease inhibitor indinavir in addition to zid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91ed41b3f7f4f729094b98bc739a3822
https://doi.org/10.1056/nejm199709113371101

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Lack of hemodynamic interaction between CGRP-receptor antagonist telcagepant (MK-0974) and sumatriptan: results from a randomized study in patients with migraine

Autor: C. Macleod, J. N. de Hoon, Deborah Panebianco, Tae H. Han, Chodakewitz Jeffrey A, I. De Lepeleire, M. G Murphy, Martin O. Behm, William B. Smith, John Palcza, Rebecca L. Blanchard, Marleen Depré

Publikováno v: Cephalalgia : an international journal of headache. 33(16)

Objective The objective of this article is to assess the effects of sumatriptan monotherapy, telcagepant monotherapy, and their combination on blood pressure (BP) in migraine patients during a headache-free period. Methods A double-blind, placebo-con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e46433a3056c8d8d2db138b8e00cfb
https://pubmed.ncbi.nlm.nih.gov/23798725

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Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men

Autor: Eric Mangin, Hong Sun, Junshui Ma, Gail Murphy, Ka Lai Yee, Xiaodong Li, Laura B. Rosen, Darren Wilbraham, Christopher Lines, Nicole Lewis, William P. Kennedy, Chodakewitz Jeffrey A, Nicole Calder, Susan Ermlich

Publikováno v: Sleep. 36(2)

Study objectives Suvorexant (MK-4305) is an orexin receptor antagonist being developed for the treatment of insomnia. This report describes the effects of nighttime administration of suvorexant on polysomnography (PSG) sleep parameters in healthy you

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f894414c518f63c0ba151aceca896fa
https://pubmed.ncbi.nlm.nih.gov/23372274

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Effect of telcagepant on spontaneous ischemia in cardiovascular patients in a randomized study

Autor: Rebecca L. Blanchard, Dawn Harris, M. Gail Murphy, Martin O. Behm, Kristin Butterfield, Richard A. Preston, Mitchell W. Krucoff, William B. Smith, John Palcza, Chodakewitz Jeffrey A

Publikováno v: Headache. 51(6)

(Headache 2011;51:954-960) Objective.— The primary purpose of the study was to explore the safety and tolerability of telcagepant in patients with stable coronary artery disease. Background.— Triptans are effective acute anti-migraine drugs whose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f251c93402149eb37c6c0b76751062fc
https://pubmed.ncbi.nlm.nih.gov/21631478

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