Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican

Autor: von Spreckelsen, N, Fadzen, CM, Hartrampf, N, Ghotmi, Y, Wolfe, J, Dubey, S, Yang, BY, Kijewski, M, Wang, S, Farquhar, C, Bergmann, S, Zdioruk, M, Wasserburg, JR, Murrell, E, Bononi, FC, Luyt, LG, Di Carli, M, Lamfers, MLM, Ligon, KL, Chiocca, EA, Viapiano, MS, Pentelute, BL, Lawler, SE, Cho, CF

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; 20210606-20210609; sine loco [digital]; DOCP125 /20210604/

Objective: Glioblastoma (GBM) is the most common and deadliest form of brain tumor and treatment options available today have limited success. Brevican (Bcan), a central nervous system (CNS)-specific extracellular matrix protein, is upregulated in hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2420cc416b6515b077e9e74512607208

Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM.

Autor: Jimenez-Macias JL; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Vaughn-Beaucaire P; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bharati A; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Xu Z; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Forrest M; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Hong J; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Sun M; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Schmidt A; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Clark J; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Hawkins W; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Mercado N; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Real J; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Huntington K; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Zdioruk M; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Nowicki MO; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Cho CF; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Harvard University, Boston, MA 02115, USA., Wu B; Cytodigm, Inc, Natick, MA 01760, USA., Li W; Phosphorex, Inc, Hopkinton, MA 01748, USA., Logan T; Phosphorex, Inc, Hopkinton, MA 01748, USA., Manz KE; School of Engineering, Brown University, Providence, RI 02912, USA., Pennell KD; School of Engineering, Brown University, Providence, RI 02912, USA., Fedeles BI; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Brodsky AS; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA., Lawler SE; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.

Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor) of the Submandibular Gland: A Case Report.

Autor: Cho CF; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung., Liu YH; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung., Lin JC; Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung.

Publikováno v: Ear, nose, & throat journal [Ear Nose Throat J] 2023 Oct; Vol. 102 (10), pp. 640-644. Date of Electronic Publication: 2021 Jun 10.

A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma.

Autor: Jimenez-Macias JL; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, RI 02903, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lee YC; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Miller E; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Finkelberg T; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zdioruk M; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Berger G; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Microbiology, Bioorganic and Macromolecular Chemistry, Faculty of Pharmacy, Université Libre de Bruxelles, Brussels 1050, Belgium., Farquhar CE; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Nowicki MO; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Cho CF; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Fedeles BI; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Loas A; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: blp@mit.edu., Lawler SE; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, RI 02903, USA. Electronic address: sean_lawler@brown.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Dec; Vol. 352, pp. 623-636. Date of Electronic Publication: 2022 Nov 04.

A Tumor-Homing Peptide Platform Enhances Drug Solubility, Improves Blood-Brain Barrier Permeability and Targets Glioblastoma.

Autor: Cho CF; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Harvard University, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Farquhar CE; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fadzen CM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Scott B; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zhuang P; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., von Spreckelsen N; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of General Neurosurgery, Centre of Neurosurgery, Faculty of Medicine and University Hospital, University of Cologne, 50937 Cologne, Germany., Loas A; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hartrampf N; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Pentelute BL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lawler SE; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.

Publikováno v: Cancers [Cancers (Basel)] 2022 Apr 28; Vol. 14 (9). Date of Electronic Publication: 2022 Apr 28.