A chimeric hydrolase-PTXD transgene enables chloroplast-based heterologous protein expression and non-sterile cultivation of Chlamydomonas reinhardtii

Autor: Simone Barera, Roberto Bassi, Luis Herrera-Estrella, Edoardo Cutolo, Luca Dall'Osto, Matteo Tosoni

Photosynthetic microalgae hold great potential as light-driven heterologous protein expression hosts. In particular, the algal chloroplast is an ideal sub-cellular site for the compartmentalized synthesis and accumulation of high-value recombinant pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c46089c7cbc50e0187dea463420fc0
https://hdl.handle.net/11392/2498900

Mass Production of Virus-Like Particles Using Chloroplast Genetic Engineering for Highly Immunogenic Oral Vaccine Against Fish Disease

Autor: Kaoru Takeuchi, Minami Tsuchikura, Hirofumi Yamashita, Kaori Mizuno, Takashi Shiina, Hidemasa Kawakami, Yoichi Nakahira

Publikováno v: Frontiers in Plant Science
Frontiers in Plant Science, Vol 12 (2021)

Nervous necrosis virus (NNV) is the causative agent of viral nervous necrosis (VNN), which is one of the most serious fish diseases leading to mass mortality in a wide range of fish species worldwide. Although a few injectable inactivated vaccines ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f29c7874b660998201bd64b2eff8c56
https://doi.org/10.3389/fpls.2021.717952

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A chloroplast transgenic approach to hyper-express and purify Human Serum Albumin, a protein highly susceptible to proteolytic degradation

Autor: Fernández San Millán, Alicia, Mingo Castel, Ángel, Miller, Michael, Daniell, Henry

Publikováno v: Academica-e: Repositorio Institucional de la Universidad Pública de Navarra
Universidad Pública de Navarra
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname

Human Serum Albumin (HSA) accounts for 60% of the total protein in blood serum and it is the most widely used intravenous protein in a number of human therapies. HSA, however, is currently extracted only from blood because of a lack of commercially f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fc66661a2a27f7cafa405d68dacdaad7
https://europepmc.org/articles/PMC3481847/

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