Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Chloride channel complex"'
Autor:
Ulrich Tacke, Claus Bræstrup
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:252-259
Benzodiazepine receptors were investigated in the cerebral cortex, the hippocampus, the brainstem, and the cerebellum of audiogenic seizure (AGS)-susceptible and seizure-resistant (ER) control rats. In AGS-susceptible rats of Sprague-Dawley descent,
Autor:
Mogens Nielsen, Michael-Robin Witt
Publikováno v:
Journal of Neurochemistry. 62:1432-1439
We have investigated the effect of unsaturated free fatty acids (FFAs) on the brain GABA/benzodiazepine receptor chloride channel complex from mammalian, avian, amphibian, and fish species in vitro. Unsaturated FFAs with a carbon chain length between
Autor:
Svante B. Ross, Diana Kelder
Publikováno v:
Pharmacology & Toxicology. 90:14-19
The effects of compounds that open the GABAA receptor-chloride channel complex on the rapidly developed tolerance to the 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide(8-OH-DPAT)-induced hypothermia in rats were examined. The test compound was i
Publikováno v:
NeuroReport. 10:3207-3210
THIS study examined the nature of the interactions of etifoxine, an anxiolytic and anticonvulsant compound, with the GABA A receptor/chloride channel complex. In membrane preparations of Sprague-Dawley rat cerebral cortex, etifoxine competitively inh
Publikováno v:
Toxicology Letters. :225-231
1. General anesthetics at clinical concentrations are known to affect neurotransmitter-gated ion channels in postsynaptic membranes. 2. Volatile anesthetics suppress excitatory transmissions, whereas they potentiate inhibitory chloride currents evoke
Autor:
Michelle D. Edwards, George Lees
Publikováno v:
British Journal of Pharmacology. 122:726-732
1 Inhalational anaesthetics modulate ligand-gated ion channels at clinical concentrations. In this paper we address submolecular mechanisms for γ-aminobutyric acid (GABA) receptor modulation by isoflurane. 2 Wild-type Drosophila melanogaster homo-ol
Autor:
A. Nabeshima, Naohiko Takahata, Shinichi Hatta, Toshikazu Saito, Masayuki Watanabe, Sadamu Toki
Publikováno v:
Alcoholism: Clinical and Experimental Research. 20:40a-44a
Changes in gamma-aminobutyric acidA (GABAA) receptor function and their relation to cross-tolerance to ethanol (EtOH) were studied in diazepam (DZP)-dependent rats. Physical dependence on DZP was induced in male Fischer rats by using the drug-admixed
Autor:
Keiichi Nagata, Toshio Narahashi
Publikováno v:
Pesticide Science. 44:1-7
The GABA A receptor-chloride channel complex is known to be the target of cyclodiene insecticides and of γ-hexachlorocyclohexane (γ-HCH, lindane). Dieldrin first enhances, then suppresses, γ-aminobutyric acid (GABA)- induced chloride currents, and
Autor:
Friedrich P. Thinnes, Susanne Reymann, Dörte Hesse, G. Paetzold, C. Moryswortmann, Götz Walter, H. Winkelbach, Harald Flörke, B. Zimmermann, Ulrike Stadtmüller, N. Hilschmann
Publikováno v:
Biochemical Medicine and Metabolic Biology. 52:120-127
Eight mouse monoclonal antibodies directed against the acetylated N-terminal part of the type 1 human VDAC Porin 31HL clearly discriminate type 1 and type 2 mammalian porin channels. This is shown by comparing synthetic N-terminal peptides of either
Autor:
Guido Guidotti, Eugene R. Rosenthal
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1191:256-266
A voltage-gated chloride channel was identified in the electric organ of the marine ray Torpedo californica by White and Miller (J. Biol. Chem. 254, 10161–10166 (1979)). The experiments reported here concern the purification and identification of t