Identification of critical genes associated with the development of asthma by co-expression modules construction

Autor: Feng Xu, Zhihua Chen, Huahao Shen, Lulu He, Xueqin Zhan

Publikováno v: Molecular Immunology. 123:18-25

Introduction Asthma is a worldwide problem that is caused by complex underlying immune dysregulation. The identification of potential prognostic markers of asthma may provide information for treatment. The purpose of this study was to explore the key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e799280955a51f9080d0b6fe5cb24157
https://doi.org/10.1016/j.molimm.2020.01.015

Significant functional differences in differentiated Conditionally Reprogrammed (CRC)- and Feeder-free Dual SMAD inhibited-expanded human nasal epithelial cells

Autor: Elvis Pandzic, Nihan Turgutoglu, Iveta Slapetova, Renee Whan, Sharon L. Wong, Ling Zhong, Shafagh A. Waters, Adam Jaffe, Nikhil T. Awatade, Laura K. Fawcett, Alexander Capraro

Publikováno v: Journal of Cystic Fibrosis. 20:364-371

Background Patient-derived airway cells differentiated at Air Liquid Interface (ALI) are valuable models for Cystic fibrosis (CF) precision therapy. Different culture expansion methods have been established to extend expansion capacity of airway basa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3619070ea2b7a4823805f76ca6bae7
https://doi.org/10.1016/j.jcf.2020.12.019

Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function

Autor: Alastair Garner, Jin Xin Zhu, Qianyi Wu, Emad Tajkhorshid, Don J. Van Meyel, Shashank Pant, Renae M. Ryan, Tomoko Ohyama, Eunjoo Cho, Azman Akhter

Publikováno v: Journal of Clinical Investigation. 132

Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory Amino Acid Transporters (EAATs) regulate extracellular glutamate by transporting it into cells, mostly glia, to terminate neurotransmis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4ad5cd2e51244be3c767de6c3485ef
https://doi.org/10.1172/jci154891

Cinobufagin Exerts Anticancer Activity in Oral Squamous Cell Carcinoma Cells through Downregulation of ANO1

Autor: Wan Namkung, Yechan Lee, Dongkyu Jeon, Eunhee Yang, Sungwoo Jo

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 12037, p 12037 (2021)

Anoctamin1 (ANO1), a calcium-activated chloride channel, is frequently overexpressed in several cancers, including oral squamous cell carcinoma (OSCC). OSCC is a highly aggressive cancer and the most common oral malignancy. ANO1 has been proposed as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb50161312fc3752499eb7327fa9a45
http://europepmc.org/articles/PMC8584692

Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Autor: Nguyen Xuan Bach, Nguyen Xuan Nhiem, Phan Van Kiem, Do Thi Trang, Chau Van Minh, Bui Huu Tai, Wan Namkung, Yohan Seo, Seung Hyun Kim, Vu Kim Thu, Seon Ju Park

Publikováno v: Phytochemistry Letters. 33:39-45

Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fab318516135cdeb2f0e34ded234fef
https://doi.org/10.1016/j.phytol.2019.07.006