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of 156
pro vyhledávání: '"Chlorcyclizine"'
Akademický článek
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Publikováno v:
Cell Chemical Biology. 27:767-769
In this issue of Cell Chemical Biology, Hu et al. (2020) demonstrate that chlorcyclizine blocks HCV fusion by targeting the putative fusion peptide on the viral envelope glycoprotein E1. The study provides new insights into the viral fusion machinery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a9ef34468752d7574c28ea3221f86c
https://doi.org/10.1016/j.chembiol.2020.06.018
https://doi.org/10.1016/j.chembiol.2020.06.018
Autor:
Scott J. Cotler, Christopher Koh, H. Martin Garraffo, Noel Southall, Theo Heller, T. Jake Liang, Susan L. Uprichard, Nathaniel Borochov, Ohad Etzion, Pallavi Surana, Ma Ai Thanda Han, Peter Walter, Preeti Dubey, Harel Dahari
Publikováno v:
Antiviral Research. 163:149-155
Background & aims Chlorcyclizine HCl (CCZ) is a piperazine-class antihistamine with anti-hepatitis C virus (HCV) activity in vitro and in vivo. In a first-in-humans study for HCV, we evaluated the antiviral effects and safety of CCZ±ribavirin (RBV),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e14afed47c9c2dd4d3c3a048bcc8295
https://doi.org/10.1016/j.antiviral.2019.01.017
https://doi.org/10.1016/j.antiviral.2019.01.017
Publikováno v:
American Journal of PharmTech Research. 9:308-314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85cd3806d3835c3a905981f50d88d5b1
https://doi.org/10.46624/ajptr.2019.v9.i1.022
https://doi.org/10.46624/ajptr.2019.v9.i1.022
Autor:
Yun Zhang, Yuying Lan
Publikováno v:
Journal of Clinical and Nursing Research. 4
Objective: To discuss the specific application of Zhuang Medicine Crystal Sugar Ye’An Decoction in senile skin pruritus and its effects on serum IgE detection level. Methods: 90 patients with senile skin pruritus admitted to our hospital from Febru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::190d5920a23845c66ee5531da6ac8ccd
https://doi.org/10.26689/jcnr.v4i6.1625
https://doi.org/10.26689/jcnr.v4i6.1625
Autor:
Adam Schafer, Veronica Soloveva, Feiyan Mo, Sina Bavari, Lijun Rong, Gregory R. J. Thatcher, Cary Retterer, Rui Xiong, Han Cheng
Publikováno v:
Antiviral Research
Ebola and Marburg are filoviruses and biosafety level 4 pathogens responsible for causing severe hemorrhagic fevers in humans with mortality rates up to 90%. The most recent outbreak in West Africa resulted in approximately 11,310 deaths in 28,616 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a558e6898487b4fba38d8bc0cb80cd55
https://doi.org/10.1016/j.antiviral.2018.07.003
https://doi.org/10.1016/j.antiviral.2018.07.003
Autor:
Jaqueline Maria Siqueira Ferreira, William Gustavo Lima, Alex Gutterres Taranto, Damiana Antonia de Fátima Nunes, Danilo Davyt, Felipe Rocha da Silva Santos, Luciana Lara dos Santos
Publikováno v:
Journal of chemical information and modeling. 60(2)
The NS2B-NS3 protease has been identified as an attractive target for drug development against Zika virus (ZIKV) and combined drug repurposing and structure-based virtual screening has improved the development of antiviral drugs. In this study, we pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3877ee35dfcb8de12e3e5f3c9a0d88
https://pubmed.ncbi.nlm.nih.gov/31850756
https://pubmed.ncbi.nlm.nih.gov/31850756
Autor:
Zongyi Hu, T. Jake Liang, Amy Wang, Xin Hu, Jingbo Xiao, Wei Zheng, Marc Ferrer, Xin Xu, Juan J. Marugan, Billy Lin, Shanshan He, Adam Rolt, Andrés E. Dulcey, Noel Southall
Publikováno v:
Journal of Medicinal Chemistry
Recently, we reported that chlorcyclizine (CCZ, Rac-2), an over-the-counter antihistamine piperazine drug, possesses in vitro and in vivo activity against hepatitis C virus. Here, we describe structure–activity relationship (SAR) efforts that resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828044e4aa9a0e116b24b1734b86750b
Autor:
Juan J. Marugan, Andrés E. Dulcey, Takuro Uchida, Marc Singleton, T. Jake Liang, Adam Rolt, Pranav Shah, Xin Xu, Emma Hughes, Michio Imamura, Amy Wang, Derek Le, Kazuaki Chayama, Zongyi Hu, Shanshan He
Publikováno v:
The Journal of infectious diseases. 217(11)
Hepatitis C virus (HCV) is a small, single-stranded, positive-sense RNA virus that infects more than an estimated 70 million people worldwide. Untreated, persistent HCV infection often results in chronic hepatitis, cirrhosis, or liver failure, with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136c10a6577815aa10a7b6211bad9843
https://pubmed.ncbi.nlm.nih.gov/29373739
https://pubmed.ncbi.nlm.nih.gov/29373739
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 145
N-glucuronidation is an important pathway for metabolism and disposition of tertiary amines in humans. This reaction is mainly catalyzed by the enzymes UGT1A4 and UGT2B10. However, the metabolic patterns of UGT1A4- and UGT2B10-mediated N-glucuronidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67752a3c883194123540f7a29f0651a
https://pubmed.ncbi.nlm.nih.gov/28803208
https://pubmed.ncbi.nlm.nih.gov/28803208