Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Chloe Robins"'
Autor:
Yanting Huang, Xiaobo Sun, Huige Jiang, Shaojun Yu, Chloe Robins, Matthew J. Armstrong, Ronghua Li, Zhen Mei, Xiaochuan Shi, Ekaterina Sergeevna Gerasimov, Philip L. De Jager, David A. Bennett, Aliza P. Wingo, Peng Jin, Thomas S. Wingo, Zhaohui S. Qin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Array-based epigenome-wide association studies only test about 2% of the CpG sites in the genome. Here, the authors describe EWASplus, a supervised machine learning strategy that extends EWAS coverage to the entire genome, and use it to identify nove
Externí odkaz:
https://doaj.org/article/65c87e8eceb04148ada622868111db36
Autor:
Elizabeth M. Kennedy, George N. Goehring, Michael H. Nichols, Chloe Robins, Divya Mehta, Torsten Klengel, Eleazar Eskin, Alicia K. Smith, Karen N. Conneely
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Gene expression can be influenced by DNA methylation 1) distally, at regulatory elements such as enhancers, as well as 2) proximally, at promoters. Our current understanding of the influence of distal DNA methylation changes on ge
Externí odkaz:
https://doaj.org/article/66a8978a0f964e29a988cd512072b3c3
Autor:
Amber L. Jolly, Chi-Hao Luan, Brendon E. Dusel, Sara F. Dunne, Michael Winding, Vishrut J. Dixit, Chloe Robins, Jennifer L. Saluk, David J. Logan, Anne E. Carpenter, Manu Sharma, Deborah Dean, Andrew R. Cohen, Vladimir I. Gelfand
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 611-620 (2016)
Long-distance intracellular transport of organelles, mRNA, and proteins (“cargo”) occurs along the microtubule cytoskeleton by the action of kinesin and dynein motor proteins, but the vast network of factors involved in regulating intracellular c
Externí odkaz:
https://doaj.org/article/4523938e4c874274bcf79c99754ac9b9
Autor:
Duc M. Duong, Aliza P. Wingo, Thomas S. Wingo, Nicholas T. Seyfried, Ekaterina S. Gerasimov, Eric M. Reiman, Chloe Robins, Eric B. Dammer, Yue Liu, David A. Bennett, Michael P. Epstein, Benjamin A. Logsdon, James J. Lah, Allan I. Levey, Jake Gockley, Philip L. De Jager, Thomas G. Beach
Publikováno v:
Nature genetics
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's disease (AD)1,2, but how these loci confer AD risk is unclear. Here, we aimed to identify loci that confer AD risk through their effects on brain protein abundance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ea0f1266bde5f5de9eace09c08042d
https://doi.org/10.1038/s41588-020-00773-z
https://doi.org/10.1038/s41588-020-00773-z
Autor:
Duc M. Duong, Eric B. Dammer, Wen Fan, Philip L. De Jager, Ekaterina S. Gerasimov, Thomas S. Wingo, Nadia V. Harerimana, Thomas G. Beach, Chloe Robins, David A. Bennett, Allan I. Levey, Aliza P. Wingo, David J. Cutler, James J. Lah, Nicholas T. Seyfried, Jacob Meigs, Eric M. Reiman, Yue Liu
Publikováno v:
Am J Hum Genet
We generated an online brain pQTL resource for 7,376 proteins through the analysis of genetic and proteomic data derived from post-mortem samples of the dorsolateral prefrontal cortex of 330 older adults. The identified pQTLs tend to be non-synonymou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a2dabd85d24870c7fd4df734b59cfc
https://europepmc.org/articles/PMC8008492/
https://europepmc.org/articles/PMC8008492/
Autor:
James J. Lah, Allan I. Levey, David J. Cutler, Duc M. Duong, Nicholas T. Seyfried, Jake Gockley, Thomas S. Wingo, Benjamin A. Logsdon, Yue Liu, Chloe Robins, David A. Bennett, Eric B. Dammer, Philip L. De Jager, Aliza P. Wingo
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c003b55544a1154248d0cc45f8bf034
https://doi.org/10.1002/alz.043865
https://doi.org/10.1002/alz.043865
Autor:
Philip L. De Jager, Michael P. Epstein, Chloe Robins, David A. Bennett, Thomas S. Wingo, Aliza P. Wingo, Anke Hüls, Karen N. Conneely
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)
Translational Psychiatry
Translational Psychiatry
Objective Major depressive disorder (MDD) arises from a combination of genetic and environmental risk factors and DNA methylation is one of the molecular mechanisms through which these factors can manifest. However, little is known about the epigenet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74b48f023a50eddb87ad0ef896a4d2b
Autor:
Grant W. Montgomery, Devin Absher, Howard W. Wiener, Joseph E. Powell, Donna K. Arnett, Elizabeth M. Kennedy, Karen N. Conneely, Allan F. McRae, Peter M. Visscher, Chloe Robins, Stella Aslibekyan, David J. Cutler
Publikováno v:
Genetics. 207:1547-1560
The evolutionary theories of mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. To better understand the relative importance of these theories, we devised a test to identify MA- and DS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc539a618f84e98a8505940040f046bc
https://doi.org/10.1534/genetics.117.300217
https://doi.org/10.1534/genetics.117.300217
Autor:
Yue Liu, Nicholas T. Seyfried, Thomas S. Wingo, Chloe Robins, David A. Bennett, James J. Lah, Allan I. Levey, Nadia V. Harerimana, Ekaterina S. Gerasimov, Duc M. Duong, Aliza P. Wingo
Publikováno v:
Biological Psychiatry. 87:S174-S175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ea74ba621f4226af1cc2adc595772ff
https://doi.org/10.1016/j.biopsych.2020.02.460
https://doi.org/10.1016/j.biopsych.2020.02.460
Autor:
Rachel D. Edgar, Thomas S. Wingo, Michael P. Epstein, Karen N. Conneely, Chloe Robins, David A. Bennett, Philip L. De Jager, Aliza P. Wingo, Anke Hüls
ObjectiveCognitive decline is a hallmark of dementia; however, the brain epigenetic signature of cognitive decline is unclear. We investigated the associations between brain tissue-based DNA methylation and cognitive trajectory.MethodsWe performed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14097df2720561b0846da0a534317199
https://doi.org/10.1101/857953
https://doi.org/10.1101/857953