Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Chloe N. Matovina"'
Autor:
S. Haihua Chu, Jonathan R. Chabon, Chloe N. Matovina, Janna C. Minehart, Bo-Ruei Chen, Jian Zhang, Vipul Kumar, Yijun Xiong, Elsa Callen, Putzer J. Hung, Zhaohui Feng, Richard P. Koche, X. Shirley Liu, Jayanta Chaudhuri, Andre Nussenzweig, Barry P. Sleckman, Scott A. Armstrong
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically b
Externí odkaz:
https://doaj.org/article/7b6e87225d7445a5aff36d4d395224c3
Autor:
Janna Minehart, Scott A. Armstrong, S. Haihua Chu, Evelyn J. Song, Andrei V. Krivtsov, Chloe N. Matovina, Richard Koche, Kenneth N. Ross, Elizabeth S. Frank, André Nussenzweig, Zhaohui Feng, Jessica L. Makofske, Jonathan Chabon, Haiming Xu
Publikováno v:
Blood Advances. 2:2478-2490
Infant B-cell acute lymphoblastic leukemias (B-ALLs) that harbor MLL-AF4 rearrangements are associated with a poor prognosis. One important obstacle to progress for this patient population is the lack of immunocompetent models that faithfully recapit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0354765d51f996efa50a9ccb4050ff5
https://doi.org/10.1182/bloodadvances.2018021592
https://doi.org/10.1182/bloodadvances.2018021592
Autor:
S. Haihua Chu, X. Shirley Liu, Jayanta Chaudhuri, Putzer J Hung, André Nussenzweig, Jian Zhang, Zhaohui Feng, Richard Koche, Bo-Ruei Chen, Elsa Callen, Yijun Xiong, Janna Minehart, Barry P. Sleckman, Vipul Kumar, Scott A. Armstrong, Chloe N. Matovina, Jonathan Chabon
Publikováno v:
iScience
iScience, Vol 23, Iss 3, Pp-(2020)
iScience, Vol 23, Iss 3, Pp-(2020)
Summary Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1c417edfd171b9f5660dc3aa4d39ae
https://pubmed.ncbi.nlm.nih.gov/32169821
https://pubmed.ncbi.nlm.nih.gov/32169821
Autor:
S Haihua, Chu, Evelyn J, Song, Jonathan R, Chabon, Janna, Minehart, Chloe N, Matovina, Jessica L, Makofske, Elizabeth S, Frank, Kenneth, Ross, Richard P, Koche, Zhaohui, Feng, Haiming, Xu, Andrei, Krivtsov, Andre, Nussenzweig, Scott A, Armstrong
Publikováno v:
Blood advances. 2(19)
Mll-Af4 and mutant N-Ras cooperate to generate an aggressive B-acute lymphoblastic leukemia murine model, recapitulating human disease.Combination MEK and ATR inhibitor treatment of Mll-Af4/N-Ras leukemia induces synergistic antileukemic effects in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c2544b87cb03c7910c2cd57ffafaafe
https://pubmed.ncbi.nlm.nih.gov/30266823
https://pubmed.ncbi.nlm.nih.gov/30266823
Autor:
Chloe N. Matovina, Jonathan Chabon, Zhaohui Feng, Putzer J Hung, Jian Zhang, Janna Minehart, Scott A. Armstrong, Barry P. Sleckman, S. Haihua Chu, Jayanta Chaudhuri, Bo-Ruei Chen, Richard Koche, X. Shirley Liu, André Nussenzweig, Elsa Callen-Moreu
Publikováno v:
Blood. 132:511-511
Rearrangement of the immunoglobulin heavy chain locus (IgH) through non-homologous end-joining (NHEJ)-mediated VDJ recombination is a requisite step in normal lymphocyte development. This process is initiated through cleavage of DNA by RAG1/2 recombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff0c587fa459fdb00e0755745e51278
https://doi.org/10.1182/blood-2018-99-111952
https://doi.org/10.1182/blood-2018-99-111952