Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Chloe Mcfadyen"'
Autor:
Jasmine H. Francis, Ana Sjoberg, Mark A. Dickson, Ronald P. DeMatteo, Chloe Mcfadyen, Li-Xuan Qin, Mary Louise Keohan, Sandra P. D'Angelo, Ciara Marie Kelly, Mrinal M. Gounder, Sinchun Hwang, William D. Tap, Cristina R. Antonescu, Samuel Singer, Alexander N. Shoushtari, Murk-Hein Heinemann, Ping Chi
Publikováno v:
Investigational New Drugs. 37:282-290
Background Preclinical studies suggest that imatinib resistance in gastrointestinal stromal tumor (GIST) can be mediated by MAP-kinase activation via fibroblast growth factor (FGF) signaling. In FGF stimulated GIST cell lines, BGJ398, a pan-FGFR kina
Autor:
Evan Rosenbaum, Sandra P. D'Angelo, Ciara Marie Kelly, Sujana Movva, Chloe Mcfadyen, William D. Tap, Ping Chi, Mercedes M. Condy, Samuel Singer, Mrinal M. Gounder, C. R. Antonescu, Mark A. Dickson, Sinchun Hwang, Li-Xuan Qin, Mary Louise Keohan, Travis Adamson
Publikováno v:
The Oncologist
Lessons Learned The combination of pexidartinib and binimetinib was safe and tolerable and demonstrated encouraging signs of efficacy in two patients with advanced gastrointestinal stromal tumor (GIST) refractory to tyrosine kinase inhibitors (TKIs).
Autor:
Jasmine H. Francis, Ping Chi, Mrinal M. Gounder, Alexander N. Shoushtari, Sinchun Hwang, Murk-Hein Heinemann, Chloe Mcfadyen, Li-Xuan Qin, Mary Louise Keohan, Samuel Singer, Cristina R. Antonescu, Ronald P. DeMatteo, Ana Sjoberg, Mark A. Dickson, William D. Tap, Sandra P. D'Angelo, Ciara Marie Kelly
Publikováno v:
Journal of Clinical Oncology. 35:11039-11039
11039 Background: Preclinical studies suggest that imatinib resistance (IR) in GIST can be mediated by MAP-kinase activation via FGF signaling. In FGF stimulated GIST cell lines, BGJ398, a pan-FGFR inhibitor in combination with imatinib, is cytotoxic