Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chloe K. Nobuhara"'
Autor:
Sonia M. Vallabh, Eric Vallabh Minikel, Victoria J. Williams, Becky C. Carlyle, Alison J. McManus, Chase D. Wennick, Anna Bolling, Bianca A. Trombetta, David Urick, Chloe K. Nobuhara, Jessica Gerber, Holly Duddy, Ingolf Lachmann, Christiane Stehmann, Steven J. Collins, Kaj Blennow, Henrik Zetterberg, Steven E. Arnold
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background Prion disease is neurodegenerative disease that is typically fatal within months of first symptoms. Clinical trials in this rapidly declining symptomatic patient population have proven challenging. Individuals at high lifetime ris
Externí odkaz:
https://doaj.org/article/c2ff48a1966d476381115596ca11dda2
Autor:
Sarah L. DeVos, Bianca T. Corjuc, Derek H. Oakley, Chloe K. Nobuhara, Riley N. Bannon, Alison Chase, Caitlin Commins, Jose A. Gonzalez, Patrick M. Dooley, Matthew P. Frosch, Bradley T. Hyman
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid-beta plaques. The presence and spread of tau pathology through the bra
Externí odkaz:
https://doaj.org/article/58f471c2d42b4591be836bf11a262f72
Autor:
Victoria J. Williams, Ingolf Lachmann, Steven E. Arnold, Chase D Wennick, Christiane Stehmann, David Urick, Bianca A. Trombetta, Jessica Gerber, Alison J. McManus, Holly Duddy, Anna Bolling, Becky C. Carlyle, Steven J. Collins, Eric Vallabh Minikel, Kaj Blennow, Henrik Zetterberg, Sonia M Vallabh, Chloe K. Nobuhara
Publikováno v:
BMC Medicine
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Background Prion disease is neurodegenerative disease that is typically fatal within months of first symptoms. Clinical trials in this rapidly declining symptomatic patient population have proven challenging. Individuals at high lifetime risk for gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ea7636f204b2183bcffdc496db6a22
https://doi.org/10.1186/s12916-020-01608-8
https://doi.org/10.1186/s12916-020-01608-8
Publikováno v:
FOCUS. 16:164-172
This article reviews the current evidence base for biomarkers of the most common causes of dementia in later life: Alzheimer’s disease (AD), frontotemporal lobar degenerations, Lewy body dementias, and vascular cognitive impairment and dementia. Bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcf138ec64cc1da09682dfda57b2596
https://doi.org/10.1176/appi.focus.20170048
https://doi.org/10.1176/appi.focus.20170048
Autor:
Sabina Capellari, Chloe K. Nobuhara, Flávia C. Nery, Jacob Aaron Klickstein, Stuart L. Schreiber, Kathryn J. Swoboda, Michael D. Geschwind, Inga Zerr, Sonia M Vallabh, Piero Parchi, Steven E. Arnold, Jiri G. Safar, Eric Kuhn, Eric Vallabh Minikel, Henrik Zetterberg, Franc Llorens
Reduction of native prion protein (PrP) levels in the brain is an attractive strategy for the treatment or prevention of human prion disease. Clinical development of any PrP-reducing therapeutic will require an appropriate pharmacodynamic biomarker:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec95166d3e8a806c62b1a50638cce60
http://hdl.handle.net/11585/695184
http://hdl.handle.net/11585/695184
Autor:
Sonia M Vallabh, Chloe K. Nobuhara, Flávia C. Nery, Franc Llorens, Eric Vallabh Minikel, Eric Kuhn, Inga Zerr, Henrik Zetterberg, Kathryn J. Swoboda, Sabina Capellari, Jacob Aaron Klickstein, Piero Parchi, Jiri G. Safar, Steven E. Arnold, Stuart L. Schreiber, Michael D. Geschwind
Reduction of native prion protein (PrP) levels in the brain is an attractive and genetically validated strategy for the treatment or prevention of human prion diseases. However, clinical development of any PrP-reducing therapeutic will require an app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a957de0a9d915a2fafe1d256a5b5b4c
Autor:
Victoria J. Williams, David Urick, Sharon K. Inouye, Madeline D'Aquilla, Chase D Wennick, Eric Vallabh Minikel, Sonia M Vallabh, Jodi-Ann Manning, Chloe K. Nobuhara, Steven E. Arnold
Publikováno v:
Alzheimer's & Dementia. 15:P579-P580
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0bba5f2271e90e9371ff260dd29a6cc
https://doi.org/10.1016/j.jalz.2019.06.1246
https://doi.org/10.1016/j.jalz.2019.06.1246
Autor:
Shuko Takeda, Susanne Wegmann, Benjamin D. Moore, Anthone W. Dunah, Rose Pitstick, Chloe K. Nobuhara, Caitlin Commins, Allyson D. Roe, Bradley T. Hyman, Paul H. Weinreb, George A. Carlson, Thierry Bussiere, Sarah L. DeVos, Christoph Hock, Anne Cheung, Jan Grimm, Fabio Montrasio, Marion Wittmann, Matthew P. Frosch, Roger M. Nitsch, Isabel Costantino
The clinical progression of Alzheimer disease (AD) is associated with the accumulation of tau neurofibrillary tangles, which may spread throughout the cortex by interneuronal tau transfer. If so, targeting extracellular tau species may slow the sprea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1219d1f2726721caa936d6e629fe50
https://europepmc.org/articles/PMC5455060/
https://europepmc.org/articles/PMC5455060/
Autor:
Rose Pitstick, Sarah L. DeVos, Samantha B. Nicholls, Ana T. Trisini Lipsanopoulos, Shuko Takeda, Murray A. Raskind, Chloe K. Nobuhara, Caitlin Commins, Bradley T. Hyman, Alexis E. Sherman, Allyson D. Roe, George A. Carlson, Susanne Wegmann, Clemens R. Scherzer, Ge Li, Elaine R. Peskind, Matthew P. Frosch, Thomas J. Montine, Zhanyun Fan, Isabel Costantino
Publikováno v:
Annals of neurology. 80(3)
Objective Cerebrospinal fluid (CSF) tau is an excellent surrogate marker for assessing neuropathological changes that occur in Alzheimer's disease (AD) patients. However, whether the elevated tau in AD CSF is just a marker of neurodegeneration or, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7f496eedf69eedf586df046d834fcb
https://pubmed.ncbi.nlm.nih.gov/27351289
https://pubmed.ncbi.nlm.nih.gov/27351289
Autor:
Chloe K. Nobuhara, Caitlin Commins, Samantha B. Nicholls, Allyson D. Roe, Sarah L. DeVos, Bradley T. Hyman, Shuko Takeda, Isabel Costantino, Daniel Irimia, George A. Carlson, Susanne Wegmann, Matthew P. Frosch, Daniel J. Müller, Rose Pitstick, Hansang Cho
Publikováno v:
Nature communications. 6
Tau pathology is known to spread in a hierarchical pattern in Alzheimer’s disease (AD) brain during disease progression, likely by trans-synaptic tau transfer between neurons. However, the tau species involved in inter-neuron propagation remains un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe7a224475ed7093fbe70b91805be2b
https://pubmed.ncbi.nlm.nih.gov/26526534
https://pubmed.ncbi.nlm.nih.gov/26526534