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pro vyhledávání: '"Chloe Jenner"'
Autor:
Graeme C. Moody, Alleyn T. Plowright, J. Matthew Wood, Matthew S. Addie, Scott Boyd, Paul D. Kemmitt, David Whalley, Chris Sheldon, Andrew V. Turnbull, Stephen Chapman, Andrew G. Leach, Pablo Morentin Gutierrez, Paul Schofield, Linda K. Buckett, William McCoull, Nicholas John Newcombe, Alan Martin Birch, Chloe Jenner, Martin J. Packer, Thorsten Nowak, Robert D. M. Davies, Susan Birtles, Steven Wang, Steve Stokes, Roger John Butlin, Suzanne S. Bowker, John Revill, Craig S. Donald, Clive Green
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(12)
A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clinical candidate 53 (AZD3988
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e16429eb9afcdf02cbee31792660806
https://pubmed.ncbi.nlm.nih.gov/22608962
https://pubmed.ncbi.nlm.nih.gov/22608962
