Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chloe J, Peach"'
Publikováno v:
Physiological reviews. 103(1)
Proteases are signaling molecules that specifically control cellular functions by cleaving protease-activated receptors (PARs). The four known PARs are members of the large family of G protein-coupled receptors. These transmembrane receptors control
Autor:
Alan Hegron, Chloe J. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Dane D. Jensen, Alex R. B. Thomsen, Brian L. Schmidt, Wendy L. Imlach, Peter Gmeiner, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonis
Autor:
Rocco Latorre, Alan Hegron, Chloe J. Peach, Shavonne Teng, Raquel Tonello, Jeffri S. Retamal, Rafael Klein-Cloud, Diana Bok, Dane D. Jensen, Lena Gottesman-Katz, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Alex R. B. Thomsen, Brian L. Schmidt, Charalabos H. Pothoulakis, Carl Rankin, Ying Xie, Hon Wai Koon, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 119
G protein–coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and sign
Autor:
Rocco, Latorre, Alan, Hegron, Chloe J, Peach, Shavonne, Teng, Raquel, Tonello, Jeffri S, Retamal, Rafael, Klein-Cloud, Diana, Bok, Dane D, Jensen, Lena, Gottesman-Katz, Jeanette, Rientjes, Nicholas A, Veldhuis, Daniel P, Poole, Brian L, Schmidt, Charalabos H, Pothoulakis, Carl, Rankin, Ying, Xie, Hon Wai, Koon, Nigel W, Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(6)
G protein-coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and signal
Autor:
Chloe J. Peach, Viviane W. Mignone, Maria Augusta Arruda, Diana C. Alcobia, Stephen J. Hill, Laura E. Kilpatrick, Jeanette Woolard
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1264 (2018)
Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although VEGF-A ligands bind to both VEGFR1 and VEGFR2, they primarily signal via
Externí odkaz:
https://doaj.org/article/df4492b8b19942cfb86f32e46f9e8201
Background: Vascular Endothelial Growth Factor A (VEGF-A) is a key mediator of angiogenesis, primarily signalling via VEGF Receptor 2 (VEGFR2). Endothelial cells also express the co-receptor Neuropilin-1 (NRP1) that potentiates VEGF-A/VEGFR2 signalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795155da681ee912f8d43c08a440f596
https://doi.org/10.22541/au.159853895.54664035
https://doi.org/10.22541/au.159853895.54664035
Autor:
Laura E. Kilpatrick, Matthew B. Robers, Steve Hill, Rachel Friedman-Ohana, Jeanette Woolard, Chloe J. Peach
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO1-8
Autor:
Thomas Machleidt, Amanda J. Wheal, Matthew B. Robers, Diana C Alcobia, Stephen J. Hill, Stephen J. Briddon, Jeanette Woolard, Kristin M. Riching, Keith V. Wood, Kris Zimmerman, Chloe J. Peach, Laura E. Kilpatrick, Rachel Friedman-Ohana
Publikováno v:
Biochemical Pharmacology. 136:62-75
Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. Here we have used a novel stoichiometric protein-labeling method to generate a fluorescent variant of VEGF (VEGF165a-TMR) labeled on a single cysteine within each pro
Publikováno v:
British Journal of Pharmacology
Background and Purpose: Vascular Endothelial Growth Factor A (VEGF-A) is a key mediator of angiogenesis. A striking feature of the binding of a fluorescent analogue of VEGF165a to NanoLuciferase-tagged VEGF Receptor 2 (VEGFR2) in living cells is that
Publikováno v:
The FASEB Journal. 33