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pro vyhledávání: '"Chloe Gulliver"'
Autor:
Chloe Gulliver, Tara Busiau, Ashleigh Byrne, Jane E. Findlay, Ralf Hoffmann, George S. Baillie
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 707-725 (2024)
A robust body of work has demonstrated that a reduction in cAMP‐specific 3′,5′‐cyclic phosphodiesterase 4D isoform 7 (PDE4D7) is linked with negative prostate cancer outcomes; however, the exact molecular mechanism that underpins this relatio
Externí odkaz:
https://doaj.org/article/40e3306a4c564677806f725011d25c00
Publikováno v:
Future Science OA, Vol 9, Iss 9 (2023)
Aim: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. Patients & methods: RNA
Externí odkaz:
https://doaj.org/article/54a2186f034a4b5fbe5ce12cc796c057
Publikováno v:
Cancers, Vol 15, Iss 1, p 262 (2022)
Objectives: To investigate the association of the prognostic risk score CAPRA&PDE4D5/7/9 as measured on pre-surgical diagnostic needle biopsy tissue with pathological outcomes after radical prostatectomies in a clinically low–intermediate-risk pati
Externí odkaz:
https://doaj.org/article/495f3d0502a94b79a27aac25e66f8f36
Publikováno v:
Future Science OA, Vol 7, Iss 2 (2021)
Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an
Externí odkaz:
https://doaj.org/article/cba462c2111b4ed29c4b84d0ff594825
Androgen signalling remains the seminal therapeutic approach for management of advanced prostate cancer. However, most tumours eventually shift towards an aggressive phenotype, characterised by androgen-independence and treatment resistance. The cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc6f8299a08d69e62e08f258bbc2bd6
https://doi.org/10.21203/rs.3.rs-2611935/v1
https://doi.org/10.21203/rs.3.rs-2611935/v1
PDE4D7 expression is diminished during progression of PCa and the phosphodiesterase has been proposed as a prognostic biomarker. RNA sequencing of PCa tissue identified sequences in the PDE4D coding region on Chr5q12 exhibiting similarities in mRNA e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93349b0ae8f9021666266ed20c420bc5
https://doi.org/10.1101/2022.06.16.496387
https://doi.org/10.1101/2022.06.16.496387
Publikováno v:
Future Science OA
Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an
Autor:
Chloe Gulliver, Catherine C. Berry, Helen Wheadon, Caroline Busch, Theresa Mulholland, Michele Zagnoni
Publikováno v:
Blood. 134:3732-3732
Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukemia (CML) patients require life-long treatment due to leukemic stem cell (LSC) persistence. LSCs reside together with mesenchymal stem cells (MSCs) and hem