Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chloe, Pass"'
Autor:
Catriona Graham, John F Dillon, Scott Semple, Neil Lachlan, Alasdair R Fraser, Jonathan Andrew Fallowfield, Francesca Moroni, Mark Macmillan, Thomas Manship, Stuart J Forbes, Paul Noel Brennan, Alison Glover, David M Morris, Chloe Pass, Neil W A McGowan, Marc L Turner, John D M Campbell
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
Introduction Liver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or proregenerative medi
Externí odkaz:
https://doaj.org/article/89f7b18180ca494fa34b4ea6b54326f8
Autor:
Ross Dobie, Vicky E. MacRae, Chloe Pass, Elspeth M. Milne, S. Faisal Ahmed, Colin Farquharson
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
Individuals with inflammatory bowel disease (IBD) often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multif
Externí odkaz:
https://doaj.org/article/1fc18fddd0d3483e9b46d23e4866c5f0
Autor:
Thomas Manship, Mark T. Macmillan, Francesca Moroni, John M. Campbell, Paul Noel Brennan, Alison Glover, Alasdair R. Fraser, John F. Dillon, Stuart J. Forbes, Neil W. A. McGowan, Neil Lachlan, David M. Morris, Marc Turner, Chloe Pass, Jonathan A. Fallowfield, Catriona Graham, Scott Semple
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open
Brennan, P N, MacMillan, M, Manship, T, Moroni, F, Glover, A, Graham, C, Semple, S, Morris, D M, Fraser, A R, Pass, C, McGowan, N W A, Turner, M L, Lachlan, N, Dillon, J F, Campbell, J D M, Fallowfield, J A & Forbes, S J 2021, ' Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) ', BMJ Open . https://doi.org/DOI: 10.1136/bmjopen-2021-053190
BMJ Open
Brennan, P N, MacMillan, M, Manship, T, Moroni, F, Glover, A, Graham, C, Semple, S, Morris, D M, Fraser, A R, Pass, C, McGowan, N W A, Turner, M L, Lachlan, N, Dillon, J F, Campbell, J D M, Fallowfield, J A & Forbes, S J 2021, ' Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) ', BMJ Open . https://doi.org/DOI: 10.1136/bmjopen-2021-053190
IntroductionLiver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or proregenerative medic
Autor:
Anne P.M. Atkinson, Benjamin J. Dwyer, Neil W. A. McGowan, Laura Bailey, Audrey Laurie, Paul Burgoyne, Stuart J. Forbes, John D. M. Campbell, Joanna Moore, Chloe Pass, Marc Turner, Alasdair R. Fraser, Akib Hamid
Publikováno v:
Cytotherapy
Fraser, A R, Pass, C, Burgoyne, P, Atkinson, A, Bailey, L, Laurie, A, W A McGowan, N, Hamid, A, Moore, J K, Dwyer, B J, Turner, M L, Forbes, S J & Campbell, J D M 2017, ' Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages : A novel cellular therapeutic for liver cirrhosis ', Cytotherapy . https://doi.org/10.1016/j.jcyt.2017.05.009
Fraser, A R, Pass, C, Burgoyne, P, Atkinson, A, Bailey, L, Laurie, A, W A McGowan, N, Hamid, A, Moore, J K, Dwyer, B J, Turner, M L, Forbes, S J & Campbell, J D M 2017, ' Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages : A novel cellular therapeutic for liver cirrhosis ', Cytotherapy . https://doi.org/10.1016/j.jcyt.2017.05.009
BACKGROUND AIMS: Autologous macrophage therapy represents a potentially significant therapeutic advance for the treatment of severe progressive liver cirrhosis. Administration of macrophages has been shown to reduce inflammation and drive fibrotic sc
Autor:
Catriona Graham, Alison Glover, Diana Julie Leeming, Benjamin J. Dwyer, Laura Bailey, Neil W. A. McGowan, Peter C. Hayes, Francesca Moroni, Joanna Moore, Emily Hargreaves, Stuart J. Forbes, Jonathan A. Fallowfield, Chloe Pass, Jacqueline Barry, Kishwar Musa, John D.M. Campbell, Stuart Doig, Donna Mitchell, Audrey Laurie, Marc Turner, Lisa Ritchie, Mette Juul Nielsen, Alasdair R. Fraser
Publikováno v:
Moroni, F, Dwyer, B, Graham, C, Pass, C, Bailey, L, Ritchie, L, Mitchell, D, Glover, A, Laurie, A, Doig, S, Hargreaves, E, Fraser, A R, Turner, M L, Campbell, J D M, McGowan, N W A, Barry, J, Moore, J K, Hayes, P C, Leeming, D J, Nielsen, M J, Musa, K, Fallowfield, J A & Forbes, S J 2019, ' Safety profile of autologous macrophage therapy for liver cirrhosis ', Nature Medicine, vol. 25, no. 10, pp. 1560–1565 . https://doi.org/10.1038/s41591-019-0599-8
Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We conducted a first-in-human, phase 1 dose-escalation trial of autologous macrophage therapy in nine adults with cirrhosis and a Model for End-Stage Liver Disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc9eab221386f055fcaef843b18027a
https://hdl.handle.net/20.500.11820/9e2a4316-c9a3-4140-a403-d4c936ddc679
https://hdl.handle.net/20.500.11820/9e2a4316-c9a3-4140-a403-d4c936ddc679
Autor:
Katherine Staines, Vicky E MacRae, Seema Jasim, Chloe Pass, Colin Farquharson, Syed Faisal Ahmed, Ross Dobie
Publikováno v:
World Review of Nutrition and Dietetics ISBN: 9783318057058
Nutrition and Growth: Yearbook 2016
Nutrition and Growth: Yearbook 2016
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb3d1d372d2ee7bd992caae54148844d
https://doi.org/10.1159/isbn.978-3-318-05706-5
https://doi.org/10.1159/isbn.978-3-318-05706-5
Autor:
Mark L. Turner, Dvina Wojtacha, Lynn Manson, Joanna Moore, Chloe Pass, Anne P.M. Atkinson, Neil W. A. McGowan, Caroline Pope, Laura Bailey, John D.M. Campbell, Stuart J. Forbes, Paul Burgoyne, Alison C. MacKinnon, Alasdair R. Fraser
Publikováno v:
Cytotherapy
Moore, J K, Mackinnon, A C, Wojtacha, D, Pope, C, Fraser, A R, Burgoyne, P, Bailey, L, Pass, C, Atkinson, A, Mcgowan, N W A, Manson, L, Turner, M L, Campbell, J D M & Forbes, S J 2015, ' Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study ', Cytotherapy . https://doi.org/10.1016/j.jcyt.2015.07.016
Moore, J K, Mackinnon, A C, Wojtacha, D, Pope, C, Fraser, A R, Burgoyne, P, Bailey, L, Pass, C, Atkinson, A, Mcgowan, N W A, Manson, L, Turner, M L, Campbell, J D M & Forbes, S J 2015, ' Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study ', Cytotherapy . https://doi.org/10.1016/j.jcyt.2015.07.016
Background aimsMacrophages have complex roles in the liver. The aim of this study was to compare profiles of human monocyte-derived macrophages between controls and cirrhotic patients, to determine whether chronic inflammation affects precursor numbe
Autor:
Natalie Mount, Emily Hargreaves, Donna Mitchell, Stuart J. Forbes, Jacqueline Barry, Alasdair R. Fraser, Benjamin J. Dwyer, Francesca Moroni, Marc Turner, Michaela Sharpe, C MacRury, Anne P.M. Atkinson, Chloe Pass, Alison Glover, Neil W. A. McGowan, John Campbell, Laura Bailey, S Doig
Publikováno v:
Cytotherapy. 19:S225
Autor:
Ross, Dobie, Syed F, Ahmed, Katherine A, Staines, Chloe, Pass, Seema, Jasim, Vicky E, MacRae, Colin, Farquharson
Publikováno v:
Journal of Cellular Physiology
Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like‐growth factor‐1 (IGF
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 27(5)
Suppressor of Cytokine Signaling-2 (SOCS2) is a negative regulator of growth hormone (GH) signaling and bone growth via inhibition of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway. This has been classically de