Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chloë Roustan"'
Autor:
Valeria Calvaresi, Antoni G. Wrobel, Joanna Toporowska, Dietmar Hammerschmid, Katie J. Doores, Richard T. Bradshaw, Ricardo B. Parsons, Donald J. Benton, Chloë Roustan, Eamonn Reading, Michael H. Malim, Steve J. Gamblin, Argyris Politis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
In this paper, the authors use hydrogen-deuterium exchange mass spectrometry to describe how the SARS-CoV-2 spike glycoprotein has evolved its structural dynamics features and receptor binding capability from the emergence of the original Wuhan isola
Externí odkaz:
https://doaj.org/article/97f9efb389ef48dfa07633acc7b2d899
Autor:
Antoni G. Wrobel, Donald J. Benton, Chloë Roustan, Annabel Borg, Saira Hussain, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding
Externí odkaz:
https://doaj.org/article/b4dd4e7327c04cb0a388bbe45794406e
Autor:
Antoni G. Wrobel, Donald J. Benton, Pengqi Xu, Lesley J. Calder, Annabel Borg, Chloë Roustan, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to hum
Externí odkaz:
https://doaj.org/article/e6fc3e78a8f74f72b0f0a1e0880a8bb4
Autor:
Antoni G. Wrobel, Donald J. Benton, Saira Hussain, Ruth Harvey, Stephen R. Martin, Chloë Roustan, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.
Externí odkaz:
https://doaj.org/article/d4d4b2a7e1194f45b301bc4c82ffd83f
Autor:
Rachel Cooley, Neesha Kara, Ning Sze Hui, Jonathan Tart, Chloë Roustan, Roger George, David C. Hancock, Brock F. Binkowski, Keith V. Wood, Mohamed Ismail, Julian Downward
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Targeting the interaction of proteins with weak binding affinities or low solubility represents a particular challenge for drug screening. The NanoLuc ® Binary Technology (NanoBiT ®) was originally developed to detect protein-protein interactions i
Externí odkaz:
https://doaj.org/article/5503a49d093b446fb52832b3b3a2efee
Autor:
Edgar Gonzalez-Rodriguez, Mia Zol-Hanlon, Ganka Bineva-Todd, Andrea Marchesi, Mark Skehel, Keira E. Mahoney, Chloë Roustan, Annabel Borg, Lucia Di Vagno, Svend Kjaer, Antoni G. Wrobel, Donald J. Benton, Philipp Nawrath, Sabine L. Flitsch, Dhira Joshi, Andrés Manuel González-Ramírez, Katalin A. Wilkinson, Robert J. Wilkinson, Emma C. Wall, Ramón Hurtado-Guerrero, Stacy A. Malaker, Benjamin Schumann
Publikováno v:
Gonzalez-Rodriguez, E, Zol-Hanlon, M, Bineva-Todd, G, Marchesi, A, Skehel, M, Mahoney, K E, Roustan, C, Borg, A, Di Vagno, L, Kjær, S, Wrobel, A G, Benton, D J, Nawrath, P, Flitsch, S L, Joshi, D, González-Ramírez, A M, Wilkinson, K A, Wilkinson, R J, Wall, E C, Hurtado-Guerrero, R, Malaker, S A & Schumann, B 2023, ' O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern ', ACS Central Science, vol. 9, no. 3, pp. 393-404 . https://doi.org/10.1021/acscentsci.2c01349
The emergence of a polybasic cleavage motif for the protease furin in the SARS-CoV-2 spike protein has been established as a major factor for enhanced viral transmission in humans. The peptide region N-terminal to that motif is extensively mutated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375bb070568530844a5ff77444ebaee
Autor:
Emma G. Jackson, Giuliano Cutolo, Bo Yang, Nageswari Yarravarapu, Mary W. N. Burns, Ganka Bineva-Todd, Chloë Roustan, James B. Thoden, Halley M. Lin-Jones, Toin H. van Kuppevelt, Hazel M. Holden, Benjamin Schumann, Jennifer J. Kohler, Christina M. Woo, Matthew R. Pratt
Publikováno v:
Acs Chemical Biology, 17, 159-170
ACS Chemical Biology
Acs Chemical Biology, 17, 1, pp. 159-170
ACS Chemical Biology
Acs Chemical Biology, 17, 1, pp. 159-170
Bio-orthogonal chemistries have revolutionized many fields. For example, metabolic chemical reporters (MCRs) of glycosylation are analogues of monosaccharides that contain a bio-orthogonal functionality, such as azides or alkynes. MCRs are metabolica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a6b42fdce89cd311e21d1c951f3f50
http://hdl.handle.net/2066/247897
http://hdl.handle.net/2066/247897
Autor:
Alexander R. van Vliet, George N. Chiduza, Sarah L. Maslen, Valerie E. Pye, Dhira Joshi, Stefano De Tito, Harold B.J. Jefferies, Evangelos Christodoulou, Chloë Roustan, Emma Punch, Javier H. Hervás, Nicola O’Reilly, J. Mark Skehel, Peter Cherepanov, Sharon A. Tooze
Publikováno v:
Molecular Cell
ATG9A and ATG2A are essential core members of the autophagy machinery. ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer, whereas ATG2A facilitates lipid flow between tethered membranes. Although both have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714ca4459c307d838c441e4654e4af52
https://doi.org/10.1016/j.molcel.2022.10.017
https://doi.org/10.1016/j.molcel.2022.10.017
Autor:
Edward J Carr, Mary Wu, Ruth Harvey, Emma C Wall, Gavin Kelly, Saira Hussain, Michael Howell, George Kassiotis, Charles Swanton, Sonia Gandhi, David LV Bauer, Roseanne E Billany, Matthew PM Graham-Brown, Joseph Beckett, Katherine Bull, Sushma Shankar, Scott Henderson, Reza Motallebzadeh, Alan D Salama, Lorraine Harper, Patrick B Mark, Stephen McAdoo, Michelle Willicombe, Rupert Beale, Sherna F Adenwalla, Paul Bird, Christopher Holmes, Katherine L Hull, Daniel S March, Haresh Selvaskandan, Jorge J Silva, Julian W Tang, Joanna Hester, Fadi Issa, Martin Barnardo, Peter J Friend, Andrew Davenport, Catriona Goodlad, Vignesh Gopalan, Theerasak Tangwonglert, Hans J Stauss, Alex G Richter, Adam F Cunningham, Marisol Perez-Toledo, Gemma D Banham, Nadya Wall, Candice L Clarke, Maria Prendecki, Bobbi Clayton, Sina Namjou, Vanessa Silva, Meghan Poulten, Philip Bawumia, Murad Miah, Samuel Sade, Mauro Miranda, Tom Taylor, Ilenia D'Angelo, Mercedes Cabrera Jarana, Mahbubur Rahman, Janet Abreu, Sandeep Sandhar, Neil Bailey, Simon Caidan, Marie Caulfield, Lorin Adams, Caitlin Kavanagh, Scott Warchal, Chelsea Sawyer, Mike Gavrielides, Jag Kandasamy, Karen Ambrose, Amy Strange, Titilayo Abiola, Nicola O'Reilly, Philip Hobson, Ana Agau-Doce, Emma Russell, Andrew Riddell, Svend Kjaer, Annabel Borg, Chloë Roustan
Publikováno v:
Lancet (London, England)
No abstract available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d83aa5ff3b319e6b5ba40ea8550d864
https://pubmed.ncbi.nlm.nih.gov/35065703
https://pubmed.ncbi.nlm.nih.gov/35065703
Autor:
Antoni G. Wrobel, Donald J. Benton, Pengqi Xu, Annabel Borg, Chloë Roustan, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Coronaviruses of bats and pangolins are implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that Spikes from Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report Cryo-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4572e8cec4bc00463fd6cf785795fdca
https://doi.org/10.21203/rs.3.rs-83072/v1
https://doi.org/10.21203/rs.3.rs-83072/v1