VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells

Autor: Virginie Menez, Thomas Kergrohen, Tal Shasha, Claudia Silva-Evangelista, Ludivine Le Dret, Lucie Auffret, Chloé Subecz, Manon Lancien, Yassine Ajlil, Irma Segoviano Vilchis, Kévin Beccaria, Thomas Blauwblomme, Estelle Oberlin, Jacques Grill, David Castel, Marie-Anne Debily

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the present study was to elucidate the mechanisms by which VRK3 depletion impact DMG-H3K27M cell fitn

Externí odkaz: https://doaj.org/article/26038bc4491a447685806cef744f67b3

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Autor: Gilles Gasser, Ilaria Ciofini, Franz Heinemann, Federica Maschietto, Mazzarine Dotou, Emilio Viñuelas Zahı́nos, Johannes Karges, Robin Vinck, Mickaël Tharaud, Chloé Subecz, Olivier Blacque, Marta Jakubaszek, Bruno Goud, Bernhard Spingler

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2020, 142 (14), pp.6578-6587. ⟨10.1021/jacs.9b13620⟩

International audience; The utilization of photodynamic therapy (PDT) for the treatment of various types of cancer has gained increasing attention over the last decades. Despite the clinical success of approved photosensitizers (PSs), their applicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b120e4b2c415a9e2f994bf4ad87b235
https://hal-insu.archives-ouvertes.fr/insu-02892038