Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models

Autor: Anne Nack, Matthias Brendel, Julia Nedelcu, Markus Daerr, Stella Nyamoya, Cordian Beyer, Carola Focke, Maximilian Deussing, Chloé Hoornaert, Peter Ponsaerts, Christoph Schmitz, Peter Bartenstein, Axel Rominger, Markus Kipp

Publikováno v: Cells, Vol 8, Iss 2, p 94 (2019)

Positron emission tomography (PET) ligands targeting the translocator protein (TSPO) represent promising tools to visualize neuroinflammation in multiple sclerosis (MS). Although it is known that TSPO is expressed in the outer mitochondria membrane,

Externí odkaz: https://doaj.org/article/6fa24f04718143e2adb687355decacb4

Distinct In Vitro Properties of Embryonic and Extraembryonic Fibroblast-Like Cells are Reflected in their in Vivo Behavior following Grafting in the Adult Mouse Brain

Autor: Roberta Costa, Irene Bergwerf, Eva Santermans, Nathalie De Vocht, Jelle Praet, Jasmijn Daans, Debbie Le Blon, Chloé Hoornaert, Kristien Reekmans, Niel Hens, Herman Goossens, Zwi Berneman, Ornella Parolini, Francesco Alviano, Peter Ponsaerts

Publikováno v: Cell Transplantation, Vol 24 (2015)

Although intracerebral transplantation of various fibroblast(-like) cell populations has been shown feasible, little is known about the actual in vivo remodeling of these cellular grafts and their environment. In this study, we aimed to compare the i

Externí odkaz: https://doaj.org/article/7295ab884d1f4c79a43734478b1cf2ff

Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity

Autor: Doryssa Hermans, Evelien Houben, Paulien Baeten, Helena Slaets, Kris Janssens, Cindy Hoeks, Baharak Hosseinkhani, Gayel Duran, Seppe Bormans, Elizabeth Gowing, Chloé Hoornaert, Lien Beckers, Wing Ka Fung, Horst Schroten, Hiroshi Ishikawa, Judith Fraussen, Ronald Thoelen, Helga E. de Vries, Gijs Kooij, Stephanie Zandee, Alexandre Prat, Niels Hellings, Bieke Broux

Publikováno v: Acta Neuropathologica. Springer Verlag
Hermans, D, Houben, E, Baeten, P, Slaets, H, Janssens, K, Hoeks, C, Hosseinkhani, B, Duran, G, Bormans, S, Gowing, E, Hoornaert, C, Beckers, L, Fung, W K, Schroten, H, Ishikawa, H, Fraussen, J, Thoelen, R, de Vries, H E, Kooij, G, Zandee, S, Prat, A, Hellings, N & Broux, B 2022, ' Oncostatin M triggers brain inflammation by compromising blood–brain barrier integrity ', Acta Neuropathologica, vol. 144, no. 2, pp. 259-281 . https://doi.org/10.1007/s00401-022-02445-0
Acta Neuropathologica, 144(2), 259-281. Springer Verlag

Oncostatin M (OSM) is an IL-6 family member which exerts neuroprotective and remyelination-promoting effects after damage to the central nervous system (CNS). However, the role of OSM in neuro-inflammation is poorly understood. Here, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352402cd1444bbe26cfc5fbe81c062c5
https://pubmed.ncbi.nlm.nih.gov/35666306

DICAM promotes T H 17 lymphocyte trafficking across the blood-brain barrier during autoimmune neuroinflammation

Autor: Marc Charabati, Camille Grasmuck, Soufiane Ghannam, Lyne Bourbonnière, Antoine P. Fournier, Marc-André Lécuyer, Olivier Tastet, Hania Kebir, Rose-Marie Rébillard, Chloé Hoornaert, Elizabeth Gowing, Sandra Larouche, Olivier Fortin, Camille Pittet, Ali Filali-Mouhim, Boaz Lahav, Robert Moumdjian, Alain Bouthillier, Marc Girard, Pierre Duquette, Romain Cayrol, Evelyn Peelen, Francisco J. Quintana, Jack P. Antel, Alexander Flügel, Catherine Larochelle, Nathalie Arbour, Stephanie Zandee, Alexandre Prat

Publikováno v: Science Translational Medicine. 14

DICAM contributes to the pathogenesis of autoimmune neuroinflammation by promoting the migration of T H 17 lymphocytes across the blood-brain barrier.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::345d3e0341e90f94b714f22cffd8f83f
https://doi.org/10.1126/scitranslmed.abj0473

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

Autor: Jelle Praet, Mathias Hoehn, Jasmijn Daans, Debbie Le Blon, Peter Ponsaerts, Alessandra Quarta, Somayyeh Hamzei Taj, Chloé Hoornaert, Annemie Van der Linden

Publikováno v: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-17 (2018)
Journal of neuroinflammation
Journal of Neuroinflammation
Journal of Neuroinflammation, 15

Background Subtle adjustment of the activation status of CNS resident microglia and peripheral macrophages, to promote their neuroprotective and neuroregenerative functions, may facilitate research towards curing neurodegenerative disorders. In the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4178d73b806acb4dd2261f96c450629
http://link.springer.com/article/10.1186/s12974-018-1212-7