Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Chloé Bellocq"'
Autor:
Isabelle Baró, Pascal Bousquet, Jean Daniel Ehrhardt, Borys Manoury, Diane Zimmermann, Laurent Monassier, Weissenburger J, Patrice Jaillon, Chloé Bellocq, Hugues Greney
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2007, 322 (1), pp.341-350
Journal of Pharmacology and Experimental Therapeutics, 2007, 322 (1), pp.341-350
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2007, 322 (1), pp.341-350
Journal of Pharmacology and Experimental Therapeutics, 2007, 322 (1), pp.341-350
The sigma(2)-receptor agonist, ifenprodil, was suggested as an inhibitor of G protein-coupled inwardly rectifying potassium channels. Nevertheless, an analysis of the role of sigma(2) receptors in cardiac electrophysiology has never been done. This w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb3eaee117c9ac77bf3181ad7d7bab5
https://doi.org/10.1124/jpet.107.122044
https://doi.org/10.1124/jpet.107.122044
Autor:
Jean Christophe Chevallier, Flavien Charpentier, Howard Motoike, Cecile Terrenoire, Colleen E. Clancy, Sophie Demolombe, Aziza El Harchi, David Mazurais, Gildas Loussouarn, Chloé Bellocq, Gilles Toumaniantz, Denis Escande, Anne Royer, Gilles Lande, Julien Piron, Khai Le Quang
Publikováno v:
Cardiovascular Research. 65:128-137
Objective: The K + channel encoded by the human ether-a`-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of HERG current (IKr) on the incidence of cardiac arrhythmias, we generated a tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81339ced696e69c697f5f4f5ea66b9f
https://doi.org/10.1016/j.cardiores.2004.09.030
https://doi.org/10.1016/j.cardiores.2004.09.030
Autor:
Chloé Bellocq, Arnaud Chambellan, Jean-Christophe Chevalier, Hugues Abriel, Céline Marionneau, Christophe Boixel, Sophie Demolombe, Khai Le Quang, Aziza El Harchi, Gilles Lande, Sabrina Le Bouter, Denis Escande, Toon A.B. van Veen, Jean J. Leger, Flavien Charpentier, Bruno Gavillet
Publikováno v:
Circulation, 110(19), 3028-3035. LIPPINCOTT WILLIAMS & WILKINS
Background— The basis for the unique effectiveness of long-term amiodarone treatment on cardiac arrhythmias is incompletely understood. The present study investigated the pharmacogenomic profile of amiodarone on genes encoding ion-channel subunits.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63fc48f5b3ef6aee13a98590bbb991a
https://research.rug.nl/en/publications/d259caa4-c454-460b-9fb7-9249a2eea13a
https://research.rug.nl/en/publications/d259caa4-c454-460b-9fb7-9249a2eea13a
Autor:
Chloé Bellocq, Hervé Le Marec, Isabelle Baró, Denis Escande, Bénédicte Louérat-Oriou, Ronald Wilders, Jean-Jacques Schott, Pierre Boisseau
Publikováno v:
Molecular pharmacology, 66(5), 1093-1102. American Society for Pharmacology and Experimental Therapeutics
QT prolongation, a classic risk factor for arrhythmias, can result from a mutation in one of the genes governing cardiac repolarization and also can result from the intake of a medication acting as blocker of the cardiac K(+) channel human ether-a-go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7f8c6e20b10cb6371ea4c9debcc21b
https://doi.org/10.1124/mol.104.001065
https://doi.org/10.1124/mol.104.001065
Autor:
Anne Forhan, Isabelle Denjoy, Franck Potet, Isabelle Baró, Bernard Hainque, Rachel Lescasse, Sophie Demolombe, Laetitia Gouas, Pascale Guicheney, Beverley Balkau, Myriam Berthet, Chloé Bellocq, Françoise Simon
Publikováno v:
Cardiovascular Research. 63:60-68
Objective: KCNQ1 mutations lead to the long QT syndrome (LQTS), characterized by a prolonged QT interval, syncopes and sudden death. However, some mutations are associated with non-penetrant phenotype (no symptoms, QTc normal or borderline). The obje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd4cceb2f03e1689110383cde672ce9c
https://doi.org/10.1016/j.cardiores.2004.02.011
https://doi.org/10.1016/j.cardiores.2004.02.011
Publikováno v:
Journal of Medical Genetics. 39:681-685
Inherited forms of long QT syndrome (LQTS) are characterised by an extended QT interval and clinical manifestations that include syncope and sudden death. The known genes in which mutations give rise to LQTS all produce components of cardiac ion chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5183401bf63efd88de9b0d260abd13
https://doi.org/10.1136/jmg.39.9.681
https://doi.org/10.1136/jmg.39.9.681
Autor:
Eric Piqueras, Herve LeMarec, Isabelle Baró, Claire Rodriguez-Lafrasse, Jacques Barhanin, Gilles Millat, Franck Potet, Jean-Jacques Schott, Robert Rousson, Chloé Bellocq, Philippe Chevalier
Publikováno v:
Heart Rhythm
Heart Rhythm, Elsevier, 2007, 4 (2), pp.170-4. ⟨10.1016/j.hrthm.2006.10.004⟩
Heart Rhythm, Elsevier, 2007, 4 (2), pp.170-4. ⟨10.1016/j.hrthm.2006.10.004⟩
BACKGROUND: The prevalence of genetic risk factors has not been systematically evaluated in the setting of complete atriventricular (AV) block complicated by long QT syndrome (LQTS). OBJECTIVE: This study was performed to determine to what extent acq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0aaa89910f77d1fbd6241b9570976e
https://pubmed.ncbi.nlm.nih.gov/17275752
https://pubmed.ncbi.nlm.nih.gov/17275752
Autor:
Mariel Alders, Antoni C.G. van Ginneken, Marcel M.A.M. Mannens, Isabelle Baró, C. R. Bezzina, Denis Escande, Arthur A. M. Wilde, Chloé Bellocq
Publikováno v:
Circulation. 109(20)
Background— The electrocardiographic short QT-interval syndrome forms a distinct clinical entity presenting with a high rate of sudden death and exceptionally short QT intervals. The disorder has recently been linked to gain-of-function mutation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebe8e098a22f0d1abe2d839bab51c21
https://pubmed.ncbi.nlm.nih.gov/15159330
https://pubmed.ncbi.nlm.nih.gov/15159330
Autor:
Kyu-Ho Park, Flavien Charpentier, Chloé Bellocq, Gildas Loussouarn, Denis Escande, Isabelle Baró
Publikováno v:
The EMBO journal. 22(20)
Phosphatidylinositol-4,5-bisphosphate (PIP(2)) is a major signaling molecule implicated in the regulation of various ion transporters and channels. Here we show that PIP(2) and intracellular MgATP control the activity of the KCNQ1/KCNE1 potassium cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342cc405cde9af09f2d9e46fca29e5e3
https://pubmed.ncbi.nlm.nih.gov/14532114
https://pubmed.ncbi.nlm.nih.gov/14532114
Autor:
Franck Aimond, Chloé Bellocq, Arnaud Chambellan, Jean J. Leger, Gilles Toumaniantz, Sepideh Siavoshian, Sabrina Le Bouter, Amber L. Pond, Isabelle Baró, Gilles Lande, Denis Escande, Flavien Charpentier, Jeanne M. Nerbonne, Sophie Demolombe
Publikováno v:
Circulation research. 92(2)
Although electrophysiological remodeling occurs in various myocardial diseases, the underlying molecular mechanisms are poorly understood. cDNA microarrays containing probes for a large population of mouse genes encoding ion channel subunits (“IonC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cdca07552f9b511f1d69b5636e6d93
https://pubmed.ncbi.nlm.nih.gov/12574152
https://pubmed.ncbi.nlm.nih.gov/12574152