Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Chloé Bars"'
Autor:
Jente Hoyberghs, Axelle Coppens, Chloé Bars, Chris Van Ginneken, Kenn Foubert, Steven Van Cruchten
Publikováno v:
Current Research in Toxicology, Vol 7, Iss , Pp 100186- (2024)
Zebrafish embryo-based assays are a promising alternative for animal testing to screen new compounds for developmental toxicity. However, recent studies in zebrafish embryos showed an immature intrinsic cytochrome P450 (CYP)-mediated biotransformatio
Externí odkaz:
https://doaj.org/article/1be485048a1648139aaa9d1f4ac364ce
Autor:
Allan Valenzuela, Miriam Ayuso, Laura Buyssens, Chloé Bars, Chris Van Ginneken, Yann Tessier, Steven Van Cruchten
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1112 (2023)
Antisense oligonucleotide (ASO) is a therapeutic modality that enables selective modulation of undruggable protein targets. However, dose- and sequence-dependent platelet count reductions have been reported in nonclinical studies and clinical trials.
Externí odkaz:
https://doaj.org/article/a581d311f8d044f28e5dbaac0a1dd2a6
Autor:
Jente Hoyberghs, Chloé Bars, Miriam Ayuso, Chris Van Ginneken, Kenn Foubert, Steven Van Cruchten
Publikováno v:
Frontiers in Toxicology, Vol 3 (2021)
Dimethyl sulfoxide (DMSO) is a popular solvent for developmental toxicity testing of chemicals and pharmaceuticals in zebrafish embryos. In general, it is recommended to keep the final DMSO concentration as low as possible for zebrafish embryos, pref
Externí odkaz:
https://doaj.org/article/81af4cdf4ff341d5badb637762fa570e
Autor:
Jente Hoyberghs, Chloé Bars, Casper Pype, Kenn Foubert, Miriam Ayuso Hernando, Chris Van Ginneken, Jonathan Ball, Steven Van Cruchten
Publikováno v:
MethodsX, Vol 7, Iss , Pp 101087- (2020)
Several pharmaceutical and chemical companies are using the zebrafish embryo as an alternative to animal testing for early detection of developmental toxicants. Unfortunately, the protocol of this zebrafish embryo assay varies between labs, resulting
Externí odkaz:
https://doaj.org/article/f1b95b36e4a144b6a84fde7738b7f544
Autor:
Chloé Bars, Jente Hoyberghs, Allan Valenzuela, Laura Buyssens, Miriam Ayuso, Chris Van Ginneken, Alain J. Labro, Kenn Foubert, Steven J. Van Cruchten
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12696 (2021)
The zebrafish (Danio rerio) embryo is gaining interest as a bridging tool between in-vitro and in-vivo developmental toxicity studies. However, cytochrome P450 (CYP)-mediated drug metabolism in this model is still under debate. Therefore, we investig
Externí odkaz:
https://doaj.org/article/5b7b0fa466474dbea3441ab3e512d8f2
Autor:
Evy Verbueken, Chloé Bars, Jonathan S. Ball, Jelena Periz-Stanacev, Waleed F. A. Marei, Anna Tochwin, Isabelle J. Gabriëls, Ellen D. G. Michiels, Evelyn Stinckens, Lucia Vergauwen, Dries Knapen, Chris J. Van Ginneken, Steven J. Van Cruchten
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3976 (2018)
The zebrafish (Danio rerio) embryo is currently explored as an alternative for developmental toxicity testing. As maternal metabolism is lacking in this model, knowledge of the disposition of xenobiotics during zebrafish organogenesis is pivotal in o
Externí odkaz:
https://doaj.org/article/b1138b6ff1414411bc582a9a85905f47
Autor:
Dries Knapen, Katyeny Manuela Da Silva, Elias Iturrospe, Chloé Bars, Adrian Covaci, Steven Van Cruchten, Alexander L.N. van Nuijs
Publikováno v:
Metabolites
Metabolites, Vol 11, Iss 635, p 635 (2021)
Metabolites, Vol 11, Iss 635, p 635 (2021)
Metabolomics has achieved great progress over the last 20 years, and it is currently considered a mature research field. As a result, the number of applications in toxicology, biomarker, and drug discovery has also increased. Toxicometabolomics has e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f42e89940e77eca9c33710621e018ab
https://doi.org/10.3390/metabo11090635
https://doi.org/10.3390/metabo11090635
Autor:
Steven Van Cruchten, Claire Tardiveau, Miriam Ayuso, Chris Van Ginneken, Paul Barrow, Laura Buyssens, Pierluigi Fant, Neil Parrott, Yann Tessier, Annamaria Braendli-Baiocco, Allan Valenzuela, Georg Schmitt, Chloé Bars, Isabelle Leconte
Publikováno v:
Pharmaceutics, Vol 13, Iss 1442, p 1442 (2021)
Pharmaceutics
Volume 13
Issue 9
Pharmaceutics
Volume 13
Issue 9
The adult Göttingen Minipig is an acknowledged model for safety assessment of antisense oligonucleotide (ASO) drugs developed for adult indications. To assess whether the juvenile Göttingen Minipig is also a suitable nonclinical model for pediatric
Autor:
Kenn Foubert, Jente Hoyberghs, Laura Buyssens, Alain J. Labro, Miriam Ayuso, Chris Van Ginneken, Allan Valenzuela, Chloé Bars, Steven Van Cruchten
Publikováno v:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
International journal of molecular sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12696
International Journal of Molecular Sciences, Vol 22, Iss 12696, p 12696 (2021)
International Journal of Molecular Sciences
International journal of molecular sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12696
International Journal of Molecular Sciences, Vol 22, Iss 12696, p 12696 (2021)
International Journal of Molecular Sciences
The zebrafish (Danio rerio) embryo is gaining interest as a bridging tool between in-vitro and in-vivo developmental toxicity studies. However, cytochrome P450 (CYP)-mediated drug metabolism in this model is still under debate. Therefore, we investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e2e85e5a3cdd8ab3d5741187de0844
https://biblio.ugent.be/publication/8750899
https://biblio.ugent.be/publication/8750899
Autor:
Casper Pype, Jente Hoyberghs, Steven Van Cruchten, Chris Van Ginneken, Kenn Foubert, Jonathan S. Ball, Miriam Ayuso Hernando, Chloé Bars
Publikováno v:
MethodsX
MethodsX, Vol 7, Iss, Pp 101087-(2020)
MethodsX, Vol 7, Iss, Pp 101087-(2020)
Several pharmaceutical and chemical companies are using the zebrafish embryo as an alternative to animal testing for early detection of developmental toxicants. Unfortunately, the protocol of this zebrafish embryo assay varies between labs, resulting