Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Microglial Model

Autor: Swati Mishra, Chizuru Kinoshita, Alison D. Axtman, Jessica E. Young

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Novel treatments for neurodegenerative disorders are in high demand. It is imperative that new protein targets be identified to address this need. Characterization and validation of nascent targets can be accomplished very effectively using highly sp

Externí odkaz: https://doaj.org/article/bdc0b4ce3af94aa2be499f224aba5c4f

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

Autor: Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce, Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)

Abstract Introduction The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the Accelerating Medicines Partnership Program for Alzheimer's Disease (AMP AD) program. Methods Publicly available resources, such as literat

Externí odkaz: https://doaj.org/article/e2d6a7a95cd548b0ab470f7102528da7

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease

Autor: Jacqueline M. Ward, Colleen A. Stoyas, Pawel M. Switonski, Farid Ichou, Weiwei Fan, Brett Collins, Christopher E. Wall, Isaac Adanyeguh, Chenchen Niu, Bryce L. Sopher, Chizuru Kinoshita, Richard S. Morrison, Alexandra Durr, Alysson R. Muotri, Ronald M. Evans, Fanny Mochel, Albert R. La Spada

Publikováno v: Cell Reports, Vol 26, Iss 5, Pp 1189-1202.e6 (2019)

Summary: Spinocerebellar ataxia type 7 (SCA7) is a retinal-cerebellar degenerative disorder caused by CAG-polyglutamine (polyQ) repeat expansions in the ataxin-7 gene. As many SCA7 clinical phenotypes occur in mitochondrial disorders, and magnetic re

Externí odkaz: https://doaj.org/article/2df87244305f454d9fc15eb814fd3cf4

Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Microglial Model.

Autor: Mishra, Swati, Chizuru Kinoshita, Axtman, Alison D., Young, Jessica E.

Publikováno v: Frontiers in Molecular Neuroscience; 2023, p1-13, 13p

The Alzheimer's gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

Autor: Swati Mishra, Allison Knupp, Marcell P. Szabo, Charles A. Williams, Chizuru Kinoshita, Dale W. Hailey, Yuliang Wang, Olav M. Andersen, Jessica E. Young

Publikováno v: Mishra, S, Knupp, A, Szabo, M P, Williams, C A, Kinoshita, C, Hailey, D W, Wang, Y, Andersen, O M & Young, J E 2022, ' The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons ', Cellular and Molecular Life Sciences, vol. 79, no. 3, 162 . https://doi.org/10.1007/s00018-022-04182-9

Background Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a causal event for Alzheimer’s disease (AD). Recent studies have established that loss of SORL1, as well as mutations in autosomal dominant AD genes APP and PSEN1/2, pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c17263fc01a2fdb8a0d47ef6461623
https://pubmed.ncbi.nlm.nih.gov/35226190