Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chiyomi Kubo"'
Autor:
Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno, Zenjiro Sampei, Masayuki Mishima, Masaki Honda, Jumpei Kiyokawa, Hiromi Suzuki, Shuichi Chiba, Mitsuyasu Tabo, Chiyomi Kubo
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTTherapeutic antibodies sometimes elicit anti-drug antibodies (ADAs) that can affect efficacy and safety. Engineered antibodies that contain artificial amino acid sequences are potentially highly immunogenic, but this is currently difficult to
Externí odkaz:
https://doaj.org/article/9c8b83e3cca74382a102aa8a0b0f06ad
Autor:
Shunsuke Ito, Tatsuya Ikuno, Masayuki Mishima, Mariko Yano, Toshiko Hara, Taichi Kuramochi, Zenjiro Sampei, Tetsuya Wakabayashi, Mitsuyasu Tabo, Shuichi Chiba, Chiyomi Kubo
Publikováno v:
Journal of Immunotoxicology, Vol 16, Iss 1, Pp 125-132 (2019)
Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA
Externí odkaz:
https://doaj.org/article/865b1a01b0cb44aba41b7a5a0489c967
Publikováno v:
Drug Delivery System. 37:378-387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be009f19f1e8987d171c1f12b86be62c
https://doi.org/10.2745/dds.37.378
https://doi.org/10.2745/dds.37.378
Autor:
Chiyomi Kubo, Taichi Kuramochi, Shuichi Chiba, Masayuki Mishima, Tetsuya Wakabayashi, Mitsuyasu Tabo, Toshiko Hara, Shunsuke Ito, Tatsuya Ikuno, Zenjiro Sampei, Mariko Yano
Publikováno v:
Journal of Immunotoxicology, Vol 16, Iss 1, Pp 125-132 (2019)
Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b147863eaf550925c7ca6c8ff3360b
https://doi.org/10.1080/1547691x.2019.1604586
https://doi.org/10.1080/1547691x.2019.1604586
Autor:
Chiyomi Kubo, Akira Takeiri, Futa Mimoto, Naoaki Murao, Shunsuke Ito, Shotaro Takata, Atsuhiko Maeda, Masaki Ishigai, Kumiko Muraoka, Yuki Iwayanagi, Ayako Takahashi, Nobuo Sekiguchi, Shuichi Chiba, Mariko Yano, Tetsuya Wakabayashi
Publikováno v:
mAbs. 10(8)
Immunogenicity is a key factor capable of influencing the efficacy and safety of therapeutic antibodies. A recently developed method called MHC-associated peptide proteomics (MAPPs) uses liquid chromatography/mass spectrometry to identify the peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58007c5ed97d97a87fc224910c5653f8
https://pubmed.ncbi.nlm.nih.gov/30199322
https://pubmed.ncbi.nlm.nih.gov/30199322
Publikováno v:
Biochemical and biophysical research communications. 502(1)
To detect potential risk of severe cytokine release syndrome, in vitro assay formats with human cells have been developed. The two major testing platforms are a combination of whole blood with aqueous-phase test articles (whole blood cytokine assay,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3978813b42805c905f3c7d813057dd34
https://pubmed.ncbi.nlm.nih.gov/29787754
https://pubmed.ncbi.nlm.nih.gov/29787754
Autor:
Mitsuyasu Tabo, Tomoaki Inoue, Corinne Ploix, Tobias Manigold, Masayuki Mishima, Toshiko Hara, Heather Hinton, Yoshika Iwata, Chiyomi Kubo, Asako Harada
Publikováno v:
The Journal of toxicological sciences. 41(4)
After the life-threatening cytokine release syndrome (CRS) occurred in the clinical study of the anti-CD28 monoclonal antibody (mAb) TGN1412, in vitro cytokine release assays using human blood cells have been proposed for non-clinical evaluation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86474e4801a2bb838abc50761fffac17
https://pubmed.ncbi.nlm.nih.gov/27432238
https://pubmed.ncbi.nlm.nih.gov/27432238
Autor:
Karsten Sauer, Sang-Mo Kwon, Satoshi Takaki, Roger M. Perlmutter, Chiyomi Kubo, Erin Armstead, Yoshinari Tezuka, Motoya Katsuki, Kazuki Nakao, Kiyoshi Takatsu
Publikováno v:
The Journal of Immunology. 170:703-710
Lnk is an adaptor protein expressed primarily in lymphocytes and hemopoietic precursor cells. Marked expansion of B lineage cells occurs in lnk−/− mice, indicating that Lnk regulates B cell production by negatively controlling pro-B cell expansio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93416a7b03b26c655bc33ec6ac1f6eb
https://doi.org/10.4049/jimmunol.170.2.703
https://doi.org/10.4049/jimmunol.170.2.703
Autor:
Makoto Okazaki, Asako Harada, Chiyomi Kubo, Yoshikazu Nishimura, Akira Takeiri, Sachiko Sone, Kenji Tanaka, Masayuki Mishima, Yukako Tachibana
Publikováno v:
Mutation research. 643(1-2)
Glycogen synthase kinase 3 (GSK3) is an attractive novel pharmacological target. Inhibition of GSK3 is recently regarded as one of the viable approaches to therapy for Alzheimer's disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b293f890d494d643de6f3954a19d484f
https://pubmed.ncbi.nlm.nih.gov/18598706
https://pubmed.ncbi.nlm.nih.gov/18598706
Autor:
Chiyomi Kubo-Akashi, Tetsuya Taga, Kiyoshi Takatsu, Ikuo Nobuhisa, Hitoshi Takizawa, Satoshi Takaki, Sang-Mo Kwon, Masanori Iseki
Publikováno v:
Blood. 107(7)
Hematopoietic stem cells (HSCs) are the key elements responsible for maintaining blood-cell production throughout life and for lymphohematopoietic reconstitution following bone marrow (BM) transplantation. Enhancement of the engrafting potential and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89606190fee62f7e754fa46a8801992d
https://pubmed.ncbi.nlm.nih.gov/16332975
https://pubmed.ncbi.nlm.nih.gov/16332975