Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Chiyoko Uchida"'
Autor:
Tao Xu, Honglai Zhang, Sung-Soo Park, Sriram Venneti, Rork Kuick, Kimberly Ha, Lowell Evan Michael, Mariarita Santi, Chiyoko Uchida, Takafumi Uchida, Ashok Srinivasan, James M. Olson, Andrzej A. Dlugosz, Sandra Camelo-Piragua, Jean-François Rual
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 3, Pp 216-225 (2017)
Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to qu
Externí odkaz:
https://doaj.org/article/59fbc91fc015461da7bd4d979381db65
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse
Externí odkaz:
https://doaj.org/article/7f8209138eef4b2f87753bca61cbf101
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168830 (2016)
While screening for an inhibitor of the peptidyl prolyl cis/trans isomerase, Pin1, we came across a brown algae polyphenol that blocks the differentiation of fibroblasts into adipocytes. However, its effectiveness on the accumulation of fat in the bo
Externí odkaz:
https://doaj.org/article/8f2ab3fd298c40bca5b934590ab685a4
Autor:
Takafumi Uchida, Kengo Furumai, Tomokazu Fukuda, Hirotada Akiyama, Mika Takezawa, Tomoichiro Asano, Fumihiro Fujimori, Chiyoko Uchida
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e31823 (2012)
A peptidyl prolyl cis/trans isomerase, Pin1, regulates insulin signal transduction. Pin1 reduces responses to insulin stimulation by binding CRTC2 (CREB-regulated transcriptional co-activator 2) and PPARγ (peroxisome prolifereator- activated recepto
Externí odkaz:
https://doaj.org/article/dd4981bc2c1e42f6b92bc4c272ed73a7
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14656 (2011)
Prolyl isomerase Pin1 may be involved in innate immunity against microbial infection, but the mechanism how Pin1 controls the innate immunity is poorly understood.Injection of lipopolysaccharide (LPS) into the mice induces inflammatory pulmonary diso
Externí odkaz:
https://doaj.org/article/e1834bee78874346b0b6db181c534202
Publikováno v:
Biochemical and biophysical research communications. 526(2)
Here we show that Gas7 inhibits phosphorylated tau fibrillogenesis by binding to phosphorylated tau at its non-WW domain, presumably F-BAR domain. We revealed that Gas7 binds to the third repeat domain of tau, the core element of tau oligomerization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e1943f59da08f49f50bc05e9317c55
https://pubmed.ncbi.nlm.nih.gov/32216967
https://pubmed.ncbi.nlm.nih.gov/32216967
Autor:
Masayoshi Tsubuki, Katsuhiko Takahashi, Noriko Takahashi, Keita Kosaka, Saori Tsushima, Chiyoko Uchida, Takafumi Uchida, Yukihiko Hara, Masafumi Hidaka
Publikováno v:
Biochemical and Biophysical Research Communications. 499:681-687
We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c88eb3d65317c0ed09016689ecb15e
https://doi.org/10.1016/j.bbrc.2018.03.212
https://doi.org/10.1016/j.bbrc.2018.03.212
Autor:
Atsuko Kurita-Suzuki, Chiyoko Uchida, Kentaro Tanemura, Yuki Kamo, Takafumi Uchida, Kenshiro Hara
Publikováno v:
Biochemical and Biophysical Research Communications. 497:388-393
A prolyl isomerase Pin1 deficient (Pin1−/−) male mice had severe testicular atrophy. We investigated the function of Pin1 in spermatogenesis by analyzing the Pin1−/− mice at reproductive age. Pin1−/− mice had lessαPLZF positive spermatog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca226396752e9e1e87c891296e08bb4e
https://doi.org/10.1016/j.bbrc.2018.02.090
https://doi.org/10.1016/j.bbrc.2018.02.090
Publikováno v:
Biochemical and Biophysical Research Communications. 493:946-951
Here we show that Pin1, a peptidyl-prolyl cis/trans isomerase which catalyzes the isomerization of phosphorylated Ser/Thr-Pro, is a regulatory molecule of thrombopoiesis. We found that mice lacking the Pin1 gene (Pin1-⁄- mice) formed more megakaryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bde137911e43d33da4124955a40a46
https://doi.org/10.1016/j.bbrc.2017.09.115
https://doi.org/10.1016/j.bbrc.2017.09.115
Autor:
Chiyoko Uchida, Mai Uchida
Publikováno v:
The Journal of Clinical Psychiatry. 78:e404-e412
OBJECTIVE: Suicide is a leading cause of death for college students. The aim of this study was to identify risk factors of suicide among college students that could improve university services to help prevent college suicide. METHODS: We conducted a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b3eb094af5ab5365e3df22eb8d18e4
https://doi.org/10.4088/jcp.16m10807
https://doi.org/10.4088/jcp.16m10807