A combination of burn wound injury and Pseudomonas infection elicits unique gene expression that enhances bacterial pathogenicity

Autor: Adrienne R. Kambouris, Jerod A. Brammer, Holly Roussey, Chixiang Chen, Alan S. Cross

Publikováno v: mBio, Vol 14, Iss 6 (2023)

ABSTRACTBurns are a leading cause of morbidity and mortality worldwide with the most common cause of death resulting from sepsis, often from Pseudomonas aeruginosa. We previously reported that a non-lethal flame burn induced an altered host immune re

Externí odkaz: https://doaj.org/article/6072333be3ad4517800dd28422a02a76

A Cartographic Tool to Predict Disease Risk-associated Pseudo-Dynamic Networks from Tissue-specific Gene Expression

Autor: Chixiang Chen, Biyi Shen, Lijun Zhang, Tonghui Yu, Ming Wang, Rongling Wu

Publikováno v: Bio-Protocol, Vol 13, Iss 1 (2023)

Understanding how genes are differentially expressed across tissues is key to reveal the etiology of human diseases. Genes are never expressed in isolation, but rather co-expressed in a community; thus, they co-act through intricate but well-orchestr

Externí odkaz: https://doaj.org/article/08418da108a3417e8c6c1caf97358838

Statistical and machine learning methods for spatially resolved transcriptomics with histology

Autor: Jian Hu, Amelia Schroeder, Kyle Coleman, Chixiang Chen, Benjamin J. Auerbach, Mingyao Li

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3829-3841 (2021)

Recent developments in spatially resolved transcriptomics (SRT) technologies have enabled scientists to get an integrated understanding of cells in their morphological context. Applications of these technologies in diverse tissues and diseases have t

Externí odkaz: https://doaj.org/article/2bcff681df8a485db34ce27a264bc6ea

SNP and Haplotype Interaction Models Reveal Association of Surfactant Protein Gene Polymorphisms With Hypersensitivity Pneumonitis of Mexican Population

Autor: Chintan K. Gandhi, Chixiang Chen, Shaili Amatya, Lili Yang, Chenqi Fu, Shouhao Zhou, Rongling Wu, Ivette Buendía-Roldan, Moisés Selman, Annie Pardo, Joanna Floros

Publikováno v: Frontiers in Medicine, Vol 7 (2021)

Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by inhalation of common environmental organic particles. Surfactant proteins (SPs) play a role in innate immunity and surfactant function. We hypothesized that singl

Externí odkaz: https://doaj.org/article/18b746747606460eb2fce7733159d703

Gerontologic Biostatistics and Data Science: Aging Research in the Era of Big Data.

Autor: Chen C; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Eurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA., Murphy TE; Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, USA., Speiser JL; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Bandeen-Roche K; Departments of Biostatistics, Medicine and Nursing, Johns Hopkins University, Baltimore, Maryland, USA., Allore H; Department of Internal Medicine, Yale School of Medicine and Department of Biostatistics Yale School of Public Health, New Haven, Connecticut, USA., Travison TG; Marcus Institute for Aging Research, Hebrew Senior Life, Boston, Massachusetts, USA.; Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Griswold M; Departments of Medicine and Data Science, University of Mississippi Medical Center, Jackson, Mississippi, USA., Shardell M; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Publikováno v: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2024 Dec 11; Vol. 80 (1).