Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Chiuwa E. Luk"'
Autor:
Wei Meng, Heather Finlay, Claudia Generaux, Chiuwa E. Luk, Tao Wang, Robert Paul Brigance, Joelle M. Onorato, Peter S. Gargalovic, Ruth R. Wexler, William A. Schumacher, Jeffrey S. Bostwick, Zulan Pi, Karen A. Rossi
Publikováno v:
Journal of Medicinal Chemistry. 64:18102-18113
This paper describes our continued efforts in the area of small-molecule apelin receptor agonists. Recently disclosed compound 2 showed an acceptable metabolic stability but demonstrated monodemethylation of the dimethoxyphenyl group to generate atro
Autor:
Ruth R. Wexler, George O. Tora, Michael Galella, Peter S. Gargalovic, Chiuwa E. Luk, Tao Wang, Claudia Generaux, Joelle M. Onorato, Heather Finlay, Ji Jiang, Carrie Xu, Yan He, Jeffrey S. Bostwick
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Heart failure (HF) treatment remains a critical unmet medical need. Studies in normal healthy volunteers and HF patients have shown that [Pyr1]apelin-13, the endogenous ligand for the APJ receptor, improves cardiac function. However, the short half-l
Autor:
Heather Finlay, Claudia Generaux, Carrie Xu, Chiuwa E. Luk, Ruth R. Wexler, Ji Jiang, James A. Johnson, Michael Galella, Jeffrey S. Bostwick, William A. Schumacher, Tao Wang, Monique Phillips, Soong-Hoon Kim, Yan He, Joelle M. Onorato, Peter S. Gargalovic, Xue-Qing Chen, David A. Gordon
Publikováno v:
Journal of medicinal chemistry. 64(6)
Apelin-13 is an endogenous peptidic agonist of the apelin receptor (APJ) receptor with the potential for improving cardiac function in heart failure patients. However, the low plasma stability of apelin-13 necessitates continuous intravenous infusion
Autor:
Xiaomei Gu, W. Griffith Humphreys, Punit Marathe, Hong Cai, Jamus MacGuire, Hong Su, Maxine Fox, Yueping Zhang, Chiuwa E. Luk, Hong Shen, Yurong Lai, Lisa Zhang, Yue-Zhong Shu, Bridget L. Morse, Elizabeth A. Dierks
Publikováno v:
Drug Metabolism and Disposition. 43:1788-1794
Unbound plasma concentrations may not reflect those in target tissues, and there is a need for methods to predict tissue partitioning. Here, we investigate the unbound liver partitioning (Kpu,u) of rosuvastatin, a substrate of hepatic organic anion t
Autor:
R. Marcus Fancher, Elizabeth A. Dierks, Jamus MacGuire, Chiuwa E. Luk, James Smalley, Kimberly A. Foster, Evan B. Janovitz, Qin Sun, Hong Cai, Maxine Fox
Publikováno v:
Pharmacology Research & Perspectives
In this study, we describe a novel approach for collecting bile from dogs and cynomolgus monkeys for metabolite profiling, ultrasound‐guided cholecystocentesis (UCC). Sampling bile by UCC twice within 24 hours was well tolerated by dogs and monkeys
Publikováno v:
Rapid Communications in Mass Spectrometry. 25:3245-3251
An early assessment of metabolite exposure in preclinical species can provide quantitative estimation on possible active or toxic metabolites. Frequently, synthetic metabolite standards are not available at the preclinical stage, precluding the quant
Publikováno v:
Rapid communications in mass spectrometry : RCM. 25(21)
An early assessment of metabolite exposure in preclinical species can provide quantitative estimation on possible active or toxic metabolites. Frequently, synthetic metabolite standards are not available at the preclinical stage, precluding the quant