Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chiung-Kuang Chen"'
Autor:
Shamila S Gunatilleke, Claudia M Calvet, Jonathan B Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C Engel, Kenny K H Ang, Joseph Mulvaney, Steven Chen, Michelle R Arkin, James H McKerrow, Larissa M Podust
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1736 (2012)
BACKGROUND:Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves. Although a major cause of morbidity and mortality due
Externí odkaz:
https://doaj.org/article/0fedffa603054e8faa798a38e8ca4f82
Autor:
Chiung-Kuang Chen, Siegfried S F Leung, Christophe Guilbert, Matthew P Jacobson, James H McKerrow, Larissa M Podust
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e651 (2010)
Chagas Disease is the leading cause of heart failure in Latin America. Current drug therapy is limited by issues of both efficacy and severe side effects. Trypansoma cruzi, the protozoan agent of Chagas Disease, is closely related to two other major
Externí odkaz:
https://doaj.org/article/3c8ebb4f64374e618f2ba5c1db8617ba
Autor:
Chiung-Kuang Chen, Patricia S Doyle, Liudmila V Yermalitskaya, Zachary B Mackey, Kenny K H Ang, James H McKerrow, Larissa M Podust
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 2, p e372 (2009)
BACKGROUND:The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for Chagas' disease chemotherapy is sterol 14alpha-demethylase (CYP51), a cytochrome P45
Externí odkaz:
https://doaj.org/article/51e432fc4c2944a1abd5e3f1ea664682
Autor:
Hartmut Luecke, Keith Munson, S. Michael Soltis, Chiung-Kuang Chen, George Sachs, Reginald McNulty, David Strugatsky
Publikováno v:
Nature
Nature, vol 493, iss 7431
Nature, vol 493, iss 7431
Half the world's population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is essential for survival in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f121dad482b05e5bd9daa076c98413
http://europepmc.org/articles/PMC3974264
http://europepmc.org/articles/PMC3974264
Autor:
Larissa M. Podust, Stephanie D. Hopkins, Jonathan B. Johnston, Matthew P. Jacobson, James H. McKerrow, Juan C. Engel, Chiung-Kuang Chen, Patricia S. Doyle, Siegfried S. F. Leung
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:2480-2488
Chagas’ disease, the leading cause of heart failure in Latin America, is caused by the kinetoplastid protozoan Trypanosoma cruzi. The sterols of T. cruzi resemble those of fungi, both in composition and in biosynthesis. Azole inhibitors of sterol 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccabf823e6a6d0c4c5e68f1d04d5bd0e
https://doi.org/10.1128/aac.00281-10
https://doi.org/10.1128/aac.00281-10
Autor:
Peter K. Kaiser, Rommie E. Amaro, A. Richard Chamberlin, Brad D. Wallentine, Faezeh Salehi, Dawei Lin, Hartmut Luecke, Chiung-Kuang Chen, Roberta Baronio, Christopher D. Wassman, Linda V. Hall, Özlem Demir, Richard H. Lathrop, Benjamin P. Chung, G. Wesley Hatfield
Publikováno v:
Nature Communications
The tumour suppressor p53 is the most frequently mutated gene in human cancer. Reactivation of mutant p53 by small molecules is an exciting potential cancer therapy. Although several compounds restore wild-type function to mutant p53, their binding s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3eadee4635ae6e8265f58c0d8ba44b
https://doi.org/10.1038/ncomms2361
https://doi.org/10.1038/ncomms2361
Autor:
Juan C. Engel, Kenny K. H. Ang, Jiri Gut, Shamila S. Gunatilleke, Jonathan B. Johnston, Claudia M. Calvet, Grigori Erenburg, Joseph Mulvaney, Chiung-Kuang Chen, Steven Chen, Larissa M. Podust, James H. McKerrow, Michelle R. Arkin
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1736 (2012)
PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases, vol 6, iss 7
PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases, vol 6, iss 7
Background Chagas Disease, a WHO- and NIH-designated neglected tropical disease, is endemic in Latin America and an emerging infection in North America and Europe as a result of population moves. Although a major cause of morbidity and mortality due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f344c719df2c1573bcd091b8fba139
http://europepmc.org/articles/PMC3409115?pdf=render
http://europepmc.org/articles/PMC3409115?pdf=render
Autor:
Larissa M. Podust, Siegfried S. F. Leung, James H. McKerrow, Matthew P. Jacobson, Christophe Guilbert, Chiung-Kuang Chen
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e651 (2010)
PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e651 (2010)
Background Chagas Disease is the leading cause of heart failure in Latin America. Current drug therapy is limited by issues of both efficacy and severe side effects. Trypansoma cruzi, the protozoan agent of Chagas Disease, is closely related to two o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ecc945f62b0948ba05ace573b12b49
http://europepmc.org/articles/PMC2850312
http://europepmc.org/articles/PMC2850312