Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chiu Yi Liu"'
Autor:
Scott Woodman, Joseph Marszalek, Alexander J Lazar, Christopher Terranova, Meng He, Timothy Heffernan, Khalida Wani, Jason Gay, Phillip Andrew Futreal, Sanjana Srinivasan, Johnathon Rose, Joseph R Daniele, Michael Peoples, Rosalba Minelli, Chiu-Yi Liu, Melinda Soeung, Luigi Perelli, Dmitry Loza, Ningping Feng, Christopher P Vellano, Giulio F Draetta, Alessandro Carugo, Giannicola Genovese, Virginia Giuliani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/573b4407054247a7b16dcebb66935ad8
Autor:
Virginia Giuliani, Meredith A. Miller, Chiu-Yi Liu, Stella R. Hartono, Caleb A. Class, Christopher A. Bristow, Erika Suzuki, Lionel A. Sanz, Guang Gao, Jason P. Gay, Ningping Feng, Johnathon L. Rose, Hideo Tomihara, Joseph R. Daniele, Michael D. Peoples, Jennifer P. Bardenhagen, Mary K. Geck Do, Qing E. Chang, Bhavatarini Vangamudi, Christopher Vellano, Haoqiang Ying, Angela K. Deem, Kim-Anh Do, Giannicola Genovese, Joseph R. Marszalek, Jeffrey J. Kovacs, Michael Kim, Jason B. Fleming, Ernesto Guccione, Andrea Viale, Anirban Maitra, M. Emilia Di Francesco, Timothy A. Yap, Philip Jones, Giulio Draetta, Alessandro Carugo, Frederic Chedin, Timothy P. Heffernan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates
Externí odkaz:
https://doaj.org/article/a1a1a41f3dcc4a47a61b299fda338c49
Autor:
Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun
Supplementary Materials and Methods Supplementary References Tables S1 to S3 and legends Figures S1 to S4 and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb5082d82bd02f09e6060ee7ba89279
https://doi.org/10.1158/0008-5472.22425706.v1
https://doi.org/10.1158/0008-5472.22425706.v1
Autor:
Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2 inhibition has demonstrated tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679aa5c2787960118aa25b0d20d0a771
https://doi.org/10.1158/0008-5472.c.6512119.v1
https://doi.org/10.1158/0008-5472.c.6512119.v1
Autor:
Johnathon L. Rose, Sanjana Srinivasan, Meng He, Rosalba Minelli, Chiu-Yi Liu, Jason Gay, Joseph R. Daniele, Michael Peoples, Melinda Soeung, Vandhana Ramamoorthy, Anastasia Lopez, Charles Deckard, Brooke Meyers, Edoardo Del Poggetto, Daniel Zamler, Justin Huang, Luigi Perelli, Khalida Wani, Christopher Bristow, Ningping Feng, Christopher P. Vellano, Joe Marszalek, Alexander J. Lazar, Andrew Futreal, Giulio F. Draetta, Scott E. Woodman, Timothy Heffernan, Giannicola Genovese, Alessandro Carugo, Virginia Giuliani
Publikováno v:
Cancer Research. 83:94-94
Uveal melanoma (UM) is a rare and lethal malignancy with very limited therapeutic options characterized by mutually exclusive activating mutations in GNAQ and GNA11, resulting in overactive proliferative signaling of Gαq/11 heterotrimeric G proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ab0a1ebfaa1d387881020b4647d96b
https://doi.org/10.1158/1538-7445.am2023-94
https://doi.org/10.1158/1538-7445.am2023-94
Autor:
Sanjana Srinivasan, Johnathon Rose, Joseph R. Daniele, Michael Peoples, Meng He, Rosalba Minelli, Chiu-Yi Liu, Jason Gay, Melinda Soeung, Khalida Wani, Luigi Perelli, Dmitriy Loza, Ningping Feng, Christopher P. Vellano, Joseph Marszalek, Giulio F. Draetta, P. Andrew Futreal, Scott E. Woodman, Alexander J. Lazar, Timothy Heffernan, Alessandro Carugo, Giannicola Genovese, Virginia Giuliani
Publikováno v:
Cancer Research. 83:92-92
Uveal Melanoma (UM) is a rare tumor characterized by mutually-exclusive activating mutations in GNAQ or GNA11, followed by a mutation event in BAP1, SF3B1 or EIF1AX. Notably, a large subset of patients present with a unique chromosome 3 copy-loss eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8448dc1c12f3bfc1cbbd3ed7c927c193
https://doi.org/10.1158/1538-7445.am2023-92
https://doi.org/10.1158/1538-7445.am2023-92
Autor:
Jennifer Bardenhagen, Mary K. Geck Do, Ernesto Guccione, Stella R. Hartono, Jason B. Fleming, Timothy P. Heffernan, Meredith A. Miller, Alessandro Carugo, Christopher A. Bristow, Virginia Giuliani, Joseph R. Marszalek, M. Emilia Di Francesco, Hideo Tomihara, Michael Peoples, Giannicola Genovese, Christopher P. Vellano, Timothy A. Yap, Erika Suzuki, Lionel A. Sanz, Anirban Maitra, Angela K. Deem, Ningping Feng, Haoqiang Ying, Jeffrey J. Kovacs, Giulio Draetta, Andrea Viale, Kim Anh Do, Frédéric Chédin, Michael P. Kim, Caleb A. Class, Guang Gao, Philip Jones, Chiu Yi Liu, Qing E. Chang, Johnathon L. Rose, Joseph R. Daniele, Bhavatarini Vangamudi
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that has remained clinically challenging to manage. Here we employ an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across a panel of patient-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea6291739dfb52921c1dcc59bb9fda1
https://escholarship.org/uc/item/2z71j3wn
https://escholarship.org/uc/item/2z71j3wn
Autor:
Qing Chang, Simon S. Yu, Christopher A. Bristow, Meredith A. Miller, Pijus K. Mandal, Yongying Jiang, Maria Emilia Di Francesco, Angela L. Harris, Christopher Carroll, Jason P Burke, Brooke A. Meyers, Zhijun Kang, Erika Suzuki, Cross Jason, Qi Wu, Connor A. Parker, Timothy McAfoos, Guang Gao, Sarah B. Johnson, Nancy E. Kohl, Ningping Feng, Yuting Sun, Chiu Yi Liu, Caroline C. Carrillo, Andy M. Zuniga, Paul G. Leonard, Sahil Seth, Virginia Giuliani, Faika Mseeh, Timothy P. Heffernan, Jeffrey J. Kovacs, Joseph R. Marszalek, Barbara Czako, Justin K. Huang, Giulio Draetta, Christopher C. Williams, Xiaoyan Ma, Anastasia M. Lopez, Nakia D. Spencer, Robert A. Mullinax, Vandhana Ramamoorthy, Philip Jones, Sonal Gera, Benjamin J. Bivona, Michael Peoples
Publikováno v:
Cancer research. 80(21)
Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases (RTK) and is required for full activation of the MAPK pathway. SHP2 inhibition has demonstrated tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614d2e4bc8f9b4ddee8a36ce57a0dcd4
https://pubmed.ncbi.nlm.nih.gov/32928921
https://pubmed.ncbi.nlm.nih.gov/32928921
Autor:
Virginia Giuliani, Alessandro Carugo, Meredith Miller, Lionel Sanz, Chiu-Yi Liu, Christopher A Bristow, Erika Suzuki, Caleb A Class, Stella R. Hartono, Guang Gao, Ningping Feng, Jason P Gay, Bhavatarini Vangamudi, Joseph R Marszalek, Jeffrey Kovacs, Maria Emilia Di Francesco, Frederic Chedin, Philip Jones, Giulio Draetta, Timothy Heffernan
Publikováno v:
Cancer Research. 79:277-277
With limited therapeutic options, poor overall 5-year survival rates, and increasing incidence, pancreas cancer is estimated to become the second leading cause of cancer deaths by 2030. Recognizing the need for transformative advances in pancreas can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5215a220ed5185c4eee6986c35f0498
https://doi.org/10.1158/1538-7445.am2019-277
https://doi.org/10.1158/1538-7445.am2019-277
Autor:
Virginia Giuliani, Timothy P. Heffernan, Erika Suzuki, Alessandro Carugo, Philip Jones, Jing Han, Chiu-Yi Liu, Yuting Sun, Ningping Feng, Giulio Draetta, Joseph R. Marszalek, Jeffrey J. Kovacs, Edward F. Chang, Meredith A. Miller, Christopher A. Bristow, Maria Emilia Di Francesco, Bhavatarini Vangamudi, Guang Gao, Carlo Toniatti
Publikováno v:
Cancer Research. 77:3016-3016
Pancreatic ductal adenocarcinoma (PDAC) is a rapidly progressing disease associated with less than 10% 5-year survival rate. Various treatment regimens failed to improve survival of PDAC patients, thus a critical need exists to identify druggable tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748ac87aed390ee441f24dba3eb608ab
https://doi.org/10.1158/1538-7445.am2017-3016
https://doi.org/10.1158/1538-7445.am2017-3016