Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling.

Autor: Armstrong E; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Chiu MKL; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.; Department of Clinical Oncology, University of Hong Kong Faculty of Medicine, Hong Kong, Hong Kong., Foo S; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Appleton L; Imperial College London, London, London, UK.; The Institute of Cancer Research, London, UK., Nenclares P; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.; Head and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK., Patrikeev A; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Mohan N; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Mclaughlin M; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Bozhanova G; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Hoebart J; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Roulstone V; The Institute of Cancer Research, London, UK., Patin E; The Institute of Cancer Research, London, UK., Pedersen M; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Kyula J; The Institute of Cancer Research, London, UK., Ono M; Imperial College London, London, London, UK., Errington-Mais F; Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK., Bell J; Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Harrington KJ; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Melcher A; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Jennings V; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK v.a.jennings@leeds.ac.uk.; Leeds Institute of Medical Research, University of Leeds, Leeds, UK.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Jul 25; Vol. 12 (7). Date of Electronic Publication: 2024 Jul 25.