Zobrazeno 1 - 5
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pro vyhledávání: '"Chitta P. Sarkar"'
Autor:
Chitta P. Sarkar, Richard J. Cenedella
Publikováno v:
Lipids. 17:46-49
The reaction of lanosterol, desmosterol and 7-dehydrocholesterol, key intermediates in cholesterol biosynthesis, were-compared with cholesterol in 3 standard colorimetric assays for cholesterol based on formation of chomogens with acetic anhydride, f
Publikováno v:
Epilepsia. 23:257-268
Summary: The concentration, half-life, and distribution in brain of U18666A, a drug that can drastically alter cerebral lipids and induce a chronic epileptiform state, was determined following both acute and chronic drug administration. U18666A speci
Publikováno v:
Epilepsia. 23:243-255
U18666A, an inhibitor of desmosterol reductase (a terminal enzyme in cholesterol synthesis), has been found to produce chronic epileptiform activity in laboratory animals. Since desmosterol might substitute for cholesterol in neuronal membranes witho
Autor:
Richard J. Cenedella, Chitta P. Sarkar
Publikováno v:
Biochemical pharmacology. 33(4)
Treatment of the rat with U18666A [3 beta-(2-diethylaminoethoxy) androst-5-en-17-one HCl] resulted in development of a chronic seizure state and 20-40% reductions in the concentration of all major phospholipid in whole brain. The mechanism of the pho
Autor:
Richard J. Cenedella, Chitta P. Sarkar
Publikováno v:
Biochimica et biophysica acta. 711(3)
The present study was undertaken to compare the content, composition and distribution of gangliosides in ocular lenses of different species, both normal and cataractous. Gangliosides were extracted from cow, pig, rat and human lens by either the Folc