Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chitrang Trivedi"'
Autor:
Suresh R. Giri, Bibhuti Bhoi, Chitrang Trivedi, Akshyaya Rath, Rohan Rathod, Anish Sharma, Ramchandra Ranvir, Shekhar Kadam, Kailash Ingale, Hiren Patel, Abraham Nyska, Mukul R. Jain
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Saroglitazar is a novel PPAR-α/γ agonist with predominant PPAR-α activity. In various preclinical models, saroglitazar has been shown to prevent & reverse symptoms of NASH. In view of these observations, and the fact that NASH
Externí odkaz:
https://doaj.org/article/20294723c6a8452ea710ad36979e2b91
Autor:
Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDA
Externí odkaz:
https://doaj.org/article/05d180e6a43443a4a0aaf1a16b919fe2
Autor:
Rashmi Ramdhave, Rohan Manubhai. Rathod, Mukul R. Jain, Akshyaya Rath, Bibhuti Bhoi, Chitrang Trivedi, Rajesh Sundar, Brijesh Kumar Srivastava, Ranjit C. Desai, Gautam D Patel, Debdutta Bandyopadhyay, Suresh Giri
Publikováno v:
Diabetes. 67
GPR40 is a G-protein-coupled receptor predominantly expressed in pancreatic β-cells. Agonists of GPR40 are known to stimulate insulin secretion and reduces circulating glucose levels in a glucose-dependent manner. TAK-875, a GPR40 small molecule ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161480e510f5deddde98f14d793f37e4
https://doi.org/10.2337/db18-1194-p
https://doi.org/10.2337/db18-1194-p
Autor:
Akshyaya Rath, Chitrang Trivedi, Bibhuti Bhoi, Suresh Giri, Mukul R. Jain, Rohan Manubhai. Rathod
Publikováno v:
Diabetes. 67
Saroglitazar is a novel dual PPARα/γ agonist that shows significant triglyceride-lowering and insulin-sensitizing effects in animal models and humans. Saroglitazar causes insulin sensitization and increases flux of lipids in adipocytes thereby prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1297e9b733e89b549f5b40933d4de667
https://doi.org/10.2337/db18-1203-p
https://doi.org/10.2337/db18-1203-p
Autor:
Chandler Ress, Timo D. Müller, Stephen C. Woods, Susanna M. Hofmann, Chitrang Trivedi, Jon Weber, Omar Al-Massadi, Chun-Xia Yi, Maarit Lehti, Elizabeth Donelan
Publikováno v:
Physiology & behavior, 106(4), 485-490. Elsevier Inc.
Physiol. Behav. 106, 485-490 (2012)
Physiol. Behav. 106, 485-490 (2012)
Hypothalamic inflammation is a potentially important process in the pathogenesis of high-fat diet-induced metabolic disorders that has recently received significant attention. Microglia are macrophage-like cells of the central nervous system which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31c74a32285c57612ef20d85f53bee7
Autor:
Baban Thube, Chitrang Trivedi, Pankaj R. Patel, Darshit Patel, Suresh Giri, Pankaj Makadia, Mukul R. Jain, Maanan Shah, Shailesh R. Shah, Dinesh Suthar, Suresh Pola, Pandurang Zaware, Priyanka Priyadarshini, Harikishore Pingali, Rajesh Bahekar
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:771-782
A novel series of thaizole and oxazole containing phenoxy acetic acid derivatives is reported as PPAR-pan agonists. Incorporation of structurally constrained oxime-ether based linker in the chemotype of a potent PPARδ selective agonist GW-501516 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00d3436dc46ec8b89c59436132c11a8
https://doi.org/10.1016/j.bmc.2010.12.023
https://doi.org/10.1016/j.bmc.2010.12.023
Autor:
Chitrang Trivedi, Ramchandra Ranvir, Bibhuti Bhoi, Pankaj R. Patel, Geeta Vanage, Suresh Giri, Purvi Vyas, Mukul R. Jain, Akshyaya Rath
Publikováno v:
Pharmacology Research & Perspectives
Saroglitazar is a novel nonthiazolidinediones (TZD) and nonfibric acid derivative designed to act as dual regulator of lipids and glucose metabolism by activating peroxisome proliferator-activated receptors (PPAR). These studies evaluate the efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2da793b0c257a94736afa60933987ec
https://doi.org/10.1002/prp2.136
https://doi.org/10.1002/prp2.136
Autor:
David A. D'Alessio, Cynthia Striese, Johannes Mansfeld, W. Sean Davidson, Kirk M. Habegger, Omar Al-Massadi, Maarit Lehti, Paul T. Pfluger, Elizabeth Donelan, Jon Weber, Susanna M. Hofmann, Michaela Keuper, Teja Ograjsek, R. A. Gangani D. Silva, William Abplanalp, Sonal Somvanshi, Radhakrishna Krishna, Chandler Ress, Julien Castel, Serge Luquet, Scott M. Gordon, Sarah Martinez, Sebastian Cucuruz, Chitrang Trivedi
Publikováno v:
Circulation. 128(22)
Background— Abnormal glucose metabolism is a central feature of disorders with increased rates of cardiovascular disease. Low levels of high-density lipoprotein (HDL) are a key predictor for cardiovascular disease. We used genetic mouse models with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23a8116b94f03104eda0ffbe35531dc
https://pubmed.ncbi.nlm.nih.gov/24170387
https://pubmed.ncbi.nlm.nih.gov/24170387
Autor:
Jenna Holland, Heiko Krude, Bruce D. Gaylinn, A Müller, Kristy M. Heppner, Kirk M. Habegger, R Sah, J Pratzka, Paul T. Pfluger, Susanna M. Hofmann, Michael O. Thorner, CW Meyer, Diego Perez-Tilve, M. H. Tschöp, Gunnar Kleinau, Carolin L. Piechowski, Brian Finan, S.C. Woods, Chitrang Trivedi, Chun-Xia Yi, Heike Biebermann, David L. Smiley, F Meyer, FR Sallee, Christine Raver, Jazzminn Hembree, Martin Bidlingmaier, Maximilian Bielohuby, Richard D. DiMarchi, William Abplanalp, Radhakrishna Krishna, Timo D. Müller, Kerstin Stemmer, Nickki Ottaway, N Bhardwaj
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::756264b543bd65767823f46c8c56d474
https://doi.org/10.1055/s-0033-1336629
https://doi.org/10.1055/s-0033-1336629
Autor:
Michael O. Thorner, Kirk M. Habegger, Gunnar Kleinau, Chun-Xia Yi, Carola W. Meyer, Jenna Holland, Franziska Meyer, Heiko Krude, Anne Müller, Floyd R. Sallee, Jazzmin Hembree, Paul T. Pfluger, Christine Raver, Kristy M. Heppner, Bruce D. Gaylinn, Martin Bidlingmaier, Heike Biebermann, Diego Perez-Tilve, Juliane Pratzka, Renu Sah, William Abplanalp, Stephen C. Woods, Timo D. Müller, Nickki Ottaway, David L. Smiley, Nakul Bhardwaj, Richard D. DiMarchi, Susanna M. Hofmann, Brian Finan, Kerstin Stemmer, Chitrang Trivedi, Radha Krishna, Carolin L. Piechowski, Matthias H. Tschöp, Maximilian Bielohuby
Publikováno v:
Nature communications, 4. Nature Publishing Group
Nature Communications
Nat. Commun. 4:1968 (2013)
Nature Communications
Nat. Commun. 4:1968 (2013)
The G protein-coupled receptor 83 (Gpr83) is widely expressed in brain regions regulating energy metabolism. Here we report that hypothalamic expression of Gpr83 is regulated in response to nutrient availability and is decreased in obese mice compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c03c3ab54da3433431d3083418e303
https://doi.org/10.1038/ncomms2968
https://doi.org/10.1038/ncomms2968
