Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chitra Telang"'
Publikováno v:
Molecular pharmaceutics. 13(9)
API-polymer interactions, used to select the right polymeric matrix with an aim to stabilize an amorphous dispersion, are routinely studied using spectroscopic and/or calorimetric techniques (i.e., melting point depression). An alternate selection to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c54d8f1523ff90a6cd76dbe42e238
https://pubmed.ncbi.nlm.nih.gov/27414755
https://pubmed.ncbi.nlm.nih.gov/27414755
Publikováno v:
Journal of Pharmaceutical Sciences. 98:4711-4723
The correlations between amorphous miscibility/physical stability of binary solid dispersions (a highly crystalline additive-an amorphous polymer) and the physicochemical properties of the components were investigated. Crystalline functional excipien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9ab88988b15e970a3bc49fb5ef1d80
https://doi.org/10.1002/jps.21779
https://doi.org/10.1002/jps.21779
Publikováno v:
Pharmaceutical Research. 20:1939-1945
To study the crystallization, polymorphism, and phase behavior of D-mannitol in binary mixtures with NaCl to better understand their interactions in frozen aqueous solutions.Differential scanning calorimetry, hot-stage microscopy, Raman microscopy, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e652f094f73477e23ae6a99a67187d6e
https://doi.org/10.1023/b:pham.0000008040.14958.bc
https://doi.org/10.1023/b:pham.0000008040.14958.bc
Publikováno v:
Pharmaceutical Research. 20:660-667
Purpose. The purpose of this work was to study the possibility of preventing mannitol crystallization in frozen solutions by using pharmaceutically acceptable additives. Methods. Differential scanning calorimetry (DSC) and low-temperature X-ray diffr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e04c6e8982425b9f3fc4e3f8d049587
https://doi.org/10.1023/a:1023263203188
https://doi.org/10.1023/a:1023263203188
Autor:
George Kukolj, Dominik Wernic, Michel Garneau, Jianmin Duan, Laibin Luo, Timothy A. Stammers, Chitra Telang, Josie De Marte, Pierre L. Beaulieu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(2)
A prodrug approach was developed to address the low oral bioavailability of a poorly soluble (0.1μg/mL in pH 6.8 buffer) but highly permeable thumb pocket 1 HCV NS5B polymerase inhibitor. Bioconversion rates of structurally diverse prodrug derivativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a0cca12d2512e623da3e160e80ae29
https://pubmed.ncbi.nlm.nih.gov/25515558
https://pubmed.ncbi.nlm.nih.gov/25515558
Autor:
Chandan Bhugra, Zeren Wang, Changquan Calvin Sun, Li Zhong, Chitra Telang, Sayantan Chattoraj
Publikováno v:
Pharmaceutical research. 29(4)
To mechanistically explain the origin of two distinct non-isothermal crystallization modes, single-peak (unimodal) and two-peak (bimodal), of organic glasses.Glasses of ten organic molecules were prepared by melt-quenching and cryogenic milling of cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a79da389aca41dbd48ae5b38fd06f63
https://pubmed.ncbi.nlm.nih.gov/22173781
https://pubmed.ncbi.nlm.nih.gov/22173781
Publikováno v:
Journal of pharmaceutical sciences. 98(6)
To investigate role of specific interactions in aiding formation and stabilization of amorphous state in ternary and binary dispersions of a weakly acidic drug. Indomethacin (IMC), meglumine (MU), and polyvinyl pyrollidone (PVP) were the model drug,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0310467dec6b33173a69ab89519bc02
https://pubmed.ncbi.nlm.nih.gov/18837038
https://pubmed.ncbi.nlm.nih.gov/18837038
Autor:
Chitra Telang, Raj Suryanarayanan
Publikováno v:
Pharmaceutical research. 22(1)
Because cephalothin sodium (I) does not crystallize readily when freeze-dried from aqueous solutions, organic cosolvents were used to increase the crystallinity of lyophilized I.Compound I was lyophilized from water-organic cosolvent (5% w/w) systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b984a5627173431832d8ac9cc982684f
https://pubmed.ncbi.nlm.nih.gov/15771242
https://pubmed.ncbi.nlm.nih.gov/15771242
Publikováno v:
Pharmaceutical research. 20(4)
The purpose of this work was to study the possibility of preventing mannitol crystallization in frozen solutions by using pharmaceutically acceptable additives.Differential scanning calorimetry (DSC) and low-temperature X-ray diffractometry (LTXRD) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd92298ffcf0abec718a1676885c10f5
https://pubmed.ncbi.nlm.nih.gov/12739776
https://pubmed.ncbi.nlm.nih.gov/12739776