Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Chitra Sundararajan"'
Publikováno v:
In Tetrahedron 16 April 2001 57(16):3419-3423
Autor:
Patrick Causey, John F. Valliant, Darren M. Weaver, Ryan Simms, Karin A. Stephenson, Chitra Sundararajan
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:18-22
A series of reactions between the technetium tricarbonyl core, [99mTc(CO)3(OH2)3]+ and both the bifunctional chelate dithiazole valeric acid (DTV) and insulin derivatized with DTV were performed using microfluidic, microwave, and conventional labelin
Autor:
Justin W. Hicks, Frank J. Femia, John W. Babich, Chitra Sundararajan, Shawn Hillier, Craig Zimmerman, Murali K. Levadala, John F. Valliant, Sangeeta Ray Banerjee, Jon Zubieta, Kevin P. Maresca, John Joyal, William C. Eckelman
Publikováno v:
Bioconjugate Chemistry. 20:1625-1633
Technetium tricarbonyl chemistry has been a subject of interest in radiopharmaceutical development over the past decade. Despite the extensive work done on developing chelates for Tc(I), a rigorous investigation of the impact of changing donor groups
Autor:
Michael S. Kovacs, John F. Valliant, Jason W. McIntee, Alfredo Capretta, Amanda C. Donovan, Chitra Sundararajan
Publikováno v:
The Journal of Organic Chemistry. 73:8236-8243
A convenient method for the preparation of fluorous aryl stannanes was developed as a means of expanding the general utility of the fluorous labeling strategy (FLS). Following the synthesis of a novel fluorous distannane, a palladium-catalyzed cross-
Autor:
Albena T. Dinkova-Kostova, Michael B. Sporn, Hidenori Yoshizawa, Gordon W. Gribble, Chitra Sundararajan, Mark M. Yore, John D. Groopman, Melinda S. Yates, Karen J. Baumgartner, Tadashi Honda, Katherine K. Stephenson, Karen T. Liby, Charlotte R. Williams, Bill D. Roebuck, Darlene B. Royce, Patricia A. Egner, Thomas W. Kensler, Renee Risingsong
Publikováno v:
Cancer Research. 68:6727-6733
A novel acetylenic tricyclic bis-(cyano enone), TBE-31, is a lead compound in a series of tricyclic compounds with enone functionalities in rings A and C. Nanomolar concentrations of this potent multifunctional molecule suppress the induction of the
Autor:
Albena T. Dinkova-Kostova, Renee Risingsong, Nanjoo Suh, Michael B. Sporn, Paul Talalay, Katherine K. Stephenson, Charlotte R. Williams, Darlene B. Royce, Tadashi Honda, Karen T. Liby, Gordon W. Gribble, Chitra Sundararajan
Publikováno v:
Molecular Cancer Therapeutics. 6:2113-2119
Betulinic acid (BA), a pentacyclic triterpene isolated from birch bark and other plants, selectively inhibits the growth of human cancer cell lines. However, the poor potency of BA hinders its clinical development, despite a lack of toxicity in anima
Autor:
Karen T. Liby, Xiaobo Su, Yukiko Honda, Hidenori Yoshizawa, Michael B. Sporn, Tadashi Honda, Gordon W. Gribble, Chitra Sundararajan
Publikováno v:
Journal of Medicinal Chemistry. 50:1731-1734
Novel C-8a functionalized tricyclic compounds having cyano enones in rings A and C have been synthesized and biologically evaluated. Among them, compounds with acetylene groups at C-8a show extremely high potency in in vitro and in vivo bioassays for
Autor:
Mark M. Yore, Gordon W. Gribble, Adriana Albini, Chitra Sundararajan, Michael B. Sporn, Karen T. Liby, Nanjoo Suh, Tadashi Honda
Publikováno v:
Drug Development Research. 68:174-182
Using the pentacyclic, naturally occurring triterpenoids, oleanolic, ursolic, and betulinic acids, as starting materials, we have developed a new series of multifunctional drugs for potential clinical use. These agents have anti-inflammatory, anti-ox
Autor:
Charlotte R. Williams, Xiaobo Su, Darlene B. Royce, Tadashi Honda, Karen T. Liby, Nanjoo Suh, Yukiko Honda, Chitra Sundararajan, Gordon W. Gribble, Michael B. Sporn, Renee Risingsong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6306-6309
Fifteen new betulinic acid analogues were designed, synthesized, and tested for anti-inflammatory activity. Many of these analogues effectively suppress nitric oxide (NO) production in RAW cells stimulated with interferon-gamma. Analogue 10 is highly
Autor:
Daniel E. Falvey, Chitra Sundararajan
Publikováno v:
Photochemical & Photobiological Sciences. 5:116-121
One electron reduction of N-alkyl-4-picolinium (NAP) esters initiates C-O bond scission releasing a carboxylate anion. Previous experiments have demonstrated that this process can be initiated by photoinduced electron transfer from an electron-donati