Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chitra Sridar"'
Publikováno v:
Xenobiotica. 43:336-345
1. UDP-glucuronosyltransferases (UGTs) are a group of drug-metabolizing enzymes that catalyse the conjugation of endogeonous compounds and xenobiotics to yield hydrophilic glucuronides which subsequently undergo excretion. This report describes an ap
Publikováno v:
Drug Metabolism and Disposition. 40:2280-2288
The nonsteroidal antiestrogen tamoxifen was introduced as a treatment for breast cancer 3 decades ago. It has also been approved as a chemopreventive agent and is prescribed to women at high risk for this disease. However, several studies have shown
Publikováno v:
Drug Metabolism and Disposition. 39:782-788
Anandamide is an arachidonic acid-derived endogenous cannabinoid that regulates normal physiological functions and pathophysiological responses within the central nervous system and in the periphery. Several cytochrome P450 (P450) isoforms metabolize
Publikováno v:
Chemical Research in Toxicology. 21:1956-1963
17-alpha-Ethynylestradiol (17EE) is a mechanism-based inactivator of P450 2B1 and P450 2B6 in the reconstituted monooxygenase system. The loss in enzymatic activity was due to the binding of a reactive intermediate of 17EE to the apoprotein. P450 2B1
Autor:
Chitra Sridar, Natasha T. Snider, Thomas J. Feuerstein, Paul F. Hollenberg, Matthew J. Sikora, James M. Rae
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 327:538-545
Members of the cytochrome P450 (P450) family of drug-metabolizing enzymes are present in the human brain, and they may have important roles in the oxidation of endogenous substrates. The polymorphic CYP2D6 is one of the major brain P450 isoforms and
SILYBIN INACTIVATES CYTOCHROMES P450 3A4 AND 2C9 AND INHIBITS MAJOR HEPATIC GLUCURONOSYLTRANSFERASES
Publikováno v:
Drug Metabolism and Disposition. 32:587-594
Silybin, a major constituent of the milk thistle, is used to treat several liver disorders. Silybin inactivated purified, recombinant cytochromes P450 (P450) 3A4 and 2C9 in a mechanism-based manner. The inactivations were time-, concentration-, and N
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:945-952
Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a chemopreventive agent for individuals at high risk for this disease. Tamoxifen is metabolized to a number of different products by cytochrome P450 enzymes. The e
Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease. Bupropion, an antidepressant, often used to treat patients in conjunction with selegiline, is metabolized primarily by CYP2B6. The effect of selegiline on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f558b0969a8d6ad624e444507ca7e76e
https://europepmc.org/articles/PMC3500550/
https://europepmc.org/articles/PMC3500550/
Publikováno v:
The FASEB Journal. 26
Autor:
Maryam Foroozesh, Ute M. Kent, Kate Noon, Chitra Sridar, Alecia McCall, Paul F. Hollenberg, Bill Alworth
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(11)
The cytochrome P450-dependent mixed-function oxidases are the main enzymes involved in the NADPH-dependent metabolism of various xenobiotics to more polar products that can be more readily excreted. In humans, the P450 3A family of enzymes are involv