Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chitra Saraiya"'
Autor:
Angus Sinclair, Thierry Giffon, Dean Ng, Poonam Yakkundi, Hope Lancero, Marigold Manlusoc, Rodnie Rosete, Avneesh Saini, Madeline Tran, Kevin Carlin, Chitra Saraiya, Ramesh Baliga, Bruce Keyt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/f409f288839b4ef28aeb52ed133e3d6e
Autor:
Rodnie Rosete, Poonam Yakkundi, Bruce Keyt, Thierry Giffon, Kevin Carlin, Ramesh Baliga, Dean Ng, Avneesh Saini, Hope Lancero, Marigold Manlusoc, Angus M. Sinclair, Madeline Tran, Chitra Saraiya
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Therapeutic antibodies inhibiting PD-1/PD-L1 have demonstrated clinical efficacy though only a fraction of patients respond. Combinations are being explored to enhance responses including anti-PD-1/PD-L1 IgG antibodies with IL-15-pathway s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4f8b37bb95a76cd07f0a66a501c3b5
https://doi.org/10.1136/jitc-2020-sitc2020.0569
https://doi.org/10.1136/jitc-2020-sitc2020.0569
Autor:
Paul Hinton, Bruce Keyt, Daniel S. Chen, Madeline H. Tran, Chitra Saraiya, Ramesh Baliga, Stephen F. Carroll, Dean C. Ng, Marigold Manlusoc, Hai Lu, Yuan C. Cao, Sachi Rahman, Bing Shan, Marvin Peterson, Keyu Li, Avneesh Saini
Publikováno v:
Cancer Research. 80:5664-5664
We have developed a novel T cell engaging bispecific antibody platform that utilizes the high avidity of IgM antibodies, but further combines this with the high affinity and specificity of IgG antibodies. By grafting the affinity matured binding doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dec4ac4d1533b85b287cbaafcb38305
https://doi.org/10.1158/1538-7445.am2020-5664
https://doi.org/10.1158/1538-7445.am2020-5664
Autor:
Bruce Keyt, Chitra Saraiya, Dean Ng, Ramesh Baliga, Steve Carroll, Avneesh Saini, Paul Hinton, Sachi Rahman, Keyu Li, Madeline Tran, Bing Shan, Marigold Manlusoc, Hai Lu, Marvin Peterson, Yuan Cao, Wayne R. Godfrey
Publikováno v:
Journal of Clinical Oncology. 38:e15007-e15007
e15007 Background: Bispecific antibodies which tether T-cells to cancer cells, and additionally activate T-cell mediated killing, have shown promise in treating B-cell malignancies. Dose intensity, however, is limited by cytokine release from the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16915fffcd12570d1b4a753f489c2e6
https://doi.org/10.1200/jco.2020.38.15_suppl.e15007
https://doi.org/10.1200/jco.2020.38.15_suppl.e15007
Autor:
Steve Carroll, Marvin Peterson, Marigold Manlusoc, Bing Shan, Hai Lu, Sachi Rahman, Ramesh Baliga, Paul Hinton, Yuan Cao, Chitra Saraiya, Bruce Keyt, Daniel S. Chen, Dean Ng, Keyu Li, Madeline Tran, Avneesh Saini
Publikováno v:
Blood. 134:1574-1574
Unlike IgG antibodies, IgM antibodies are typically composed of a pentameric disc-like structure with 10 low affinity binding sites per molecule complexed with a joining chain (J-chain) protein. We have developed a novel T cell engaging bispecific an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0e6d26fddb5fbfb741e751a4cd37fc
https://doi.org/10.1182/blood-2019-131650
https://doi.org/10.1182/blood-2019-131650
Publikováno v:
Proceedings of the National Academy of Sciences. 87:3728-3732
Alternative splicing generates various Ly-5 glycoprotein isoforms of the cell surface that typify different cell lineages and stages of hematopoietic differentiation in the mouse; exons 4-6 are incorporated to generate a B-cell isoform (B220) and exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3f24194e3023af0db2e5adc5254f9f
https://doi.org/10.1073/pnas.87.10.3728
https://doi.org/10.1073/pnas.87.10.3728
Autor:
Yaddanapudi Ravindranath, M Varadi, L Li, Jorge F. DiMartino, Ron Yu, Susana C. Raimondi, Branimir I. Sikic, Chitra Saraiya, Norman J. Lacayo, Gary V. Dahl
Publikováno v:
Leukemia. 20(3)
Secreted protein, acidic and rich in cysteine (SPARC), is a matricellular glycoprotein with growth-inhibitory and antiangiogenic functions. Although SPARC has been implicated as a tumor suppressor in humans, its function in normal or malignant hemato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8568d6012d7bb707a55c7a707de98b8
https://pubmed.ncbi.nlm.nih.gov/16424866
https://pubmed.ncbi.nlm.nih.gov/16424866
Autor:
Soheil Meshinchi, Maureen M. O'Brien, Myron Chang, Branimir I. Sikic, Yaddanapudi Ravindranath, Susana C. Raimondi, Chitra Saraiya, Dejan Juric, Gary V. Dahl, Norman J. Lacayo, Robert Tibshirani, Howard Weinstein, Ronald Yu, Cheryl L. Willman
Publikováno v:
Blood. 106:2372-2372
The event-free survival (EFS) estimate for patients with normal karyotype (NK) on COG study POG #9421 (n=144) was 36%. We previously reported a subgroup of patients (n=68) with AML and NK that could be divided into 2 groups whose clinical outcomes co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::488b2f8017fc177cf6310a00eca7e0ff
https://doi.org/10.1182/blood.v106.11.2372.2372
https://doi.org/10.1182/blood.v106.11.2372.2372
Autor:
Yaddanapudi Ravindranath, Howard Weinstein, Dennis J. Kuo, Chitra Saraiya, Ron Yu, Robert Tibshirani, Myron Chang, Branimir I. Sikic, Lorrie Douglas, Norman J. Lacayo, Gary V. Dahl, Steven Buck, C. L. Willman
Publikováno v:
Blood. 104:1130-1130
Daunorubicin and cytarabine are the most effective chemotherapeutic agents for AML. Using MTT (3,[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays as an in vitro test for sensitivity to these agents, investigators have found that leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc36b1ec5d47eec13b7b16090b59e0c
https://doi.org/10.1182/blood.v104.11.1130.1130
https://doi.org/10.1182/blood.v104.11.1130.1130