Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Chitose Oneyama"'
Autor:
Fumie Mitani, Jianyu Lin, Tatsuya Sakamoto, Ryo Uehara, Tomoya Hikita, Takuya Yoshida, Andi Setiawan, Masayoshi Arai, Chitose Oneyama
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Cancer cells secrete aberrantly large amounts of extracellular vesicles (EVs) including exosomes, which originate from multivesicular bodies (MVBs). Because EVs potentially contribute to tumor progression, EV inhibitors are of interest as no
Externí odkaz:
https://doaj.org/article/1a6636c7420f4abbb5b55c3f044c96a4
Autor:
Ryosuke Hayasaka, Sho Tabata, Masako Hasebe, Satsuki Ikeda, Tomoya Hikita, Chitose Oneyama, Jun Yoshitake, Daisuke Onoshima, Kumiko Takahashi, Takahiro Shibata, Koji Uchida, Yoshinobu Baba, Tomoyoshi Soga, Masaru Tomita, Akiyoshi Hirayama
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Cancer-derived small extracellular vesicles (sEVs) are multifunctional particles with a lipid bilayer structure that are involved in cancer progression, such as malignant proliferation, distant metastasis, and cancer immunity evasion. The separation
Externí odkaz:
https://doaj.org/article/ae8ad54e7a964820a6d9d622d040ef46
Autor:
Shin Morioka, Hiroki Nakanishi, Toshiyoshi Yamamoto, Junya Hasegawa, Emi Tokuda, Tomoya Hikita, Tomoko Sakihara, Yuuki Kugii, Chitose Oneyama, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Different phosphoinositide isomers are involved in a variety of physiological and pathological processes. Here, the authors combine chiral column chromatography and mass spectrometry to measure phosphoinositide regioisomers, revealing their dynamic c
Externí odkaz:
https://doaj.org/article/86945ee841384d22b480e5b663720b37
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249388 (2021)
Oncogene addiction is a cellular property by which cancer cells become highly dependent on the expression of oncogenes for their survival. Oncogene addiction can be exploited to design molecularly targeted drugs that kill only cancer cells by inhibit
Externí odkaz:
https://doaj.org/article/db767a58397a415381dbf7522b4e94d2
Publikováno v:
Microorganisms, Vol 7, Iss 5, p 119 (2019)
Epstein-Barr virus (EBV) genomes, particularly their latent genes, are heterogeneous among strains. The heterogeneity of EBV-encoded latent membrane protein 1 (LMP1) raises the question of whether there are functional differences between LMP1 express
Externí odkaz:
https://doaj.org/article/a8bab35c16fc42fc9f7417c96f4726a2
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0119015 (2015)
The activity of the mechanistic target of rapamycin (mTOR) is elevated in various types of human cancers, implicating a role in tumor progression. However, the molecular mechanisms underlying mTOR upregulation remain unclear. In this study, we found
Externí odkaz:
https://doaj.org/article/793924c6ecdd4200a0ae2bd5d2234d1a
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93470 (2014)
The tyrosine kinase c-Src is upregulated in numerous human cancers, implying a role for c-Src in cancer progression. Previously, we have shown that sequestration of activated c-Src into lipid rafts via a transmembrane adaptor, Cbp/PAG1, efficiently s
Externí odkaz:
https://doaj.org/article/b662045c2e0140ca8c043ca2850ca3e5
Autor:
Shunsuke Mori, Shigeyuki Nada, Hironobu Kimura, Shoji Tajima, Yusuke Takahashi, Ayaka Kitamura, Chitose Oneyama, Masato Okada
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88891 (2014)
The mechanistic target of rapamycin (mTOR) functions as a component of two large complexes, mTORC1 and mTORC2, which play crucial roles in regulating cell growth and homeostasis. However, the molecular mechanisms by which mTOR controls cell prolifera
Externí odkaz:
https://doaj.org/article/fcaa4ba4730f4236a3a5ef76b55ee5bc
Autor:
Chitose Oneyama, Yoriko Kito, Rei Asai, Jun-ichiro Ikeda, Takuya Yoshida, Daisuke Okuzaki, Rie Kokuda, Kyoko Kakumoto, Ken-ichi Takayama, Satoshi Inoue, Eiichi Morii, Masato Okada
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80300 (2013)
mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific
Externí odkaz:
https://doaj.org/article/8670d7cb97c449a39cb6314a7ccd8123
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:1572-1580
Extracellular vesicles (EVs) originating from intraluminal vesicles (ILVs) formed within multivesicular bodies (MVBs), often referred to as small EV (sEV) or exosomes, are aberrantly produced by cancer cells and regulate the tumor microenvironment. T