Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chithra Amalini"'
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 2.9MB, In-vitro kinase assay, Histology, Cell proliferation, MANOVA analysis for genomic correlates of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ecb3048e6ff5affcb194a51978b5d1
https://doi.org/10.1158/1535-7163.22497421
https://doi.org/10.1158/1535-7163.22497421
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
Dysregulation of the PI3K/mTOR pathway, either through amplifications, deletions, or as a direct result of mutations, has been closely linked to the development and progression of a wide range of cancers. Moreover, this pathway activation is a poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389efae3908c20bd53e37aa050195e71
https://doi.org/10.1158/1535-7163.c.6535609
https://doi.org/10.1158/1535-7163.c.6535609
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 663K, Ambit kinome tree, Cell proliferation data, Pharmacokinetics, Body weight changes in PC3 efficacy study, Active vessel stain in COLO-205 efficacy study, MV4-11 efficacy model, Drug sensitivity profiling and correlation to mutation st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407e7e397fec9712aed4f01696117bc4
https://doi.org/10.1158/1535-7163.22497424
https://doi.org/10.1158/1535-7163.22497424
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
XLS file - 167K, Table 1: Cell line drug sensitivity data for SB2343 and mutations in cancer genes. Table 2: Results from MANOVA analysis of cancer genes as modifiers of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794bb76ff68be2e6a52cec2e5c03efb5
https://doi.org/10.1158/1535-7163.22497418
https://doi.org/10.1158/1535-7163.22497418
Autor:
Jeanette Marjorie Wood, Ramesh Jayaraman, Yong Cheng Tan, Stefan Hart, Khalis M Pasha, Veronica Novotny-Diermayr, Albert Cheong, Kantharaj Ethirajulu, Nurulhuda Mustafa, B. K. Ng, Lai Chun Ong, Boon Cher Goh, Chithra Amalini, Wee Joo Chng, Babita Madan, Ultan McDermott, Meredith Williams, Harish Kumar Mysore Nagaraj, Kee Chuan Goh, Brian W. Dymock, Cyril H. Benes, Mathew J. Garnett
Dysregulation of the PI3K/mTOR pathway, either through amplifications, deletions, or as a direct result of mutations, has been closely linked to the development and progression of a wide range of cancers. Moreover, this pathway activation is a poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5563f504dd744af76e5286ea49281647
https://europepmc.org/articles/PMC3588144/
https://europepmc.org/articles/PMC3588144/
Autor:
Kiat Hoe Ong, Chithra Amalini, Stefan Hart, Brian Dymock, Babita Madan, L C Ong, Anthony D. William, Y C Tan, Ramesh Jayaraman, A Lee, K C Goh, Kantharaj Ethirajulu, J W Wood, C Y Hu, V Novotny-Diermayr, Y.K. Loh, Anders Poulsen, Hannes Hentze
Publikováno v:
Leukemia. 25(11)
SB1518 is an innovative pyrimidine-based macrocycle that shows a unique kinase profile with selective inhibition of Janus Kinase-2 (JAK2; IC50=23 and 19 nM for JAK2(WT) and JAK2(V617F), respectively) within the JAK family (IC50=1280, 520 and 50 nM fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8c50d78e8f0d90a8a8b70e34155fa5
https://pubmed.ncbi.nlm.nih.gov/21691275
https://pubmed.ncbi.nlm.nih.gov/21691275
Autor:
Chithra Amalini, Jianbiao Zhou, K C Goh, Y C Tan, Babita Madan, J.M. Wood, V Novotny-Diermayr, Wee Joo Chng, L C Ong, Stefan Hart, B Kheng, Angela Cheong
Publikováno v:
Blood Cancer Journal
FMS-like tyrosine kinase 3 (FLT3) is the most commonly mutated gene found in acute myeloid leukemia (AML) patients and its activating mutations have been proven to be a negative prognostic marker for clinical outcome. Pacritinib (SB1518) is a tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb134110fa1e7315fc1f1da2df060b33
https://doi.org/10.1038/bcj.2011.43
https://doi.org/10.1038/bcj.2011.43
Autor:
Brian W. Dymock, Jeanette Marjorie Wood, Angeline Lee, Lai Chun Ong, Kantharaj Ethirajulu, Stefan Hart, Yung Kiang Loh, Ramesh Jayaraman, Anders Poulsen, Yong Cheng Tan, Chithra Amalini, Anthony D. William, Veronica Novotny-Diermayr, Babita Madan, Kee Chuan Goh
Publikováno v:
Cancer Research. 71:3570-3570
Introduction: Janus kinase 2 (JAK2) and fms-related tyrosine kinase 3 (FLT3) are important tyrosine kinases in hematopoietic progenitor cell differentiation and proliferation. Aberrant signaling of JAK2 or FLT3 is implicated in various myeloid malign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::252af337d91916dc4f961df9cad03bb5
https://doi.org/10.1158/1538-7445.am2011-3570
https://doi.org/10.1158/1538-7445.am2011-3570
Publikováno v:
Cancer Research. 70:2524-2524
Introduction FLT3 and JAK2 are tyrosine kinases with crucial roles in hematopoietic progenitor cell survival and proliferation. Over-expression and/or mutation of FLT3 is frequently detected in acute myeloid leukemias (AML) and are strongly associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a8694fb0f14bf143b94785d0fbae166
https://doi.org/10.1158/1538-7445.am10-2524
https://doi.org/10.1158/1538-7445.am10-2524
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