p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

Autor: Constance Qiao Xin Yeo, Irina Alexander, Zhaoru Lin, Shuhui Lim, Obed Akwasi Aning, Ramesh Kumar, Kanda Sangthongpitag, Vishal Pendharkar, Vincent H.B. Ho, Chit Fang Cheok

Publikováno v: Cell Reports, Vol 15, Iss 1, Pp 132-146 (2016)

p53 tumor suppressor maintains genomic stability, typically acting through cell-cycle arrest, senescence, and apoptosis. We discovered a function of p53 in preventing conflicts between transcription and replication, independent of its canonical roles

Externí odkaz: https://doaj.org/article/0184466ffcac4a899df77042cd31e8a6

Nitro-Deficient Niclosamide Confers Reduced Genotoxicity and Retains Mitochondrial Uncoupling Activity for Cancer Therapy

Autor: Jin Hui Hor, Shuwen Chen, Gamal Ahmed Elfar, Chit Fang Cheok, Nicholas Phua, Tsz Wai Ngai, Ying Swan Ho, Pearlyn Yeo

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10420, p 10420 (2021)

Niclosamide is an oral anthelmintic drug, approved for use against tapeworm infections. Recent studies suggest however that niclosamide may have broader clinical applications in cancers, spurring increased interest in the functions and mechanisms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d0c0d80aa696d530386119cf4994ff

Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoids

Autor: Juergen A. Knoblich, Dong Shin Park, Florent Ginhoux, Shiming Ma, Sarah R. Langley, Kagistia Hana Utami, Chit Fang Cheok, Magdalena Renner, Obed Akwasi Aning, Jinqiu Zhang, Enrico Petretto, Mahmoud A. Pouladi, Jolene Ooi

Huntington disease (HD) manifests in both adult and juvenile forms. Mutant HTT gene carriers are thought to undergo normal brain development followed by a degenerative phase, resulting in progressive clinical manifestations. However, recent studies i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af3705fa5830833e1f74dd20d431199
https://doi.org/10.1101/850586

A48 Expanded HTT cag repeats disrupt the balance between neural progenitor expansion and differentiation in isogenic human cerebral organoids

Autor: Enrico Petretto, Obed Akwasi Aning, Jinqiu Zhang, Juergen A. Knoblich, Sarah R. Langley, Chit Fang Cheok, Mahmoud A. Pouladi, Jolene Ooi, Magdalena Renner

Publikováno v: Pathogenic mechanisms.

Huntington disease (HD) manifests in both adult and juvenile forms. A widely accepted view posits that mutant HTT gene carriers undergo normal brain development followed some years later by a degenerative phase that ultimately results in progressive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae2401310b61c841d60a831c1b7ef6a5
https://doi.org/10.1136/jnnp-2018-ehdn.46

Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability

Autor: Chit Fang Cheok, Ramesh Kumar

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

RIF1 plays a key role in inhibiting DNA end resection and promoting NHEJ mediated DNA double stand break repair in G1. However, whether SUMOlyation may regulate RIF1 functions is still largely unknown. Here, we report that RIF1 is SUMOlyated in respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7507d4c2212dcbf9f6d2c727915eb050
http://europepmc.org/articles/PMC5727183