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Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in vitro
Publikováno v:
European Journal of Pharmaceutical Sciences. 22:25-31
The phosphoramidate triester prodrug approach is widely used to deliver nucleotide forms of nucleoside analogues into target cells. We investigated the stereoselective stability of a series of prodrugs of the anti-HIV agent 2′,3′-didehydro-2′,3