Dimethyl fumarate improves white matter function following severe hypoperfusion:involvement of microglia/macrophages and inflammatory mediators

Autor: Fowler, Jill H, McQueen, Jamie, Holland, Philip R, Manso, Yasmina, Marangoni, Martina, Scott, Fiona, Chisholm, Emma, Scannevin, Robert H, Hardingham, Giles E, Horsburgh, Karen

Publikováno v: Fowler, J H, Mcqueen, J, Holland, P, Manso Sanz, Y, Marangoni, M, Scott, F, Chisholm, E, Scannevin, R H, Hardingham, G E & Horsburgh, K 2018, ' Dimethyl fumarate improves white matter function following severe hypoperfusion : involvement of microglia/macrophages and inflammatory mediators ', Journal of Cerebral Blood Flow and Metabolism, vol. 38, no. 8, pp. 1354-1370 . https://doi.org/10.1177/0271678X17713105
Journal of Cerebral Blood Flow & Metabolism

The brain's white matter is highly vulnerable to reductions in cerebral blood flow via mechanisms that may involve elevated microgliosis and pro-inflammatory pathways. In the present study, the effects of severe cerebral hypoperfusion were investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d16b350979c665b795585b55ed23ea91
https://hdl.handle.net/20.500.11820/baaf985d-0f52-48dc-83b1-4072ee088be7

SEVERE CEREBRAL HYPOPERFUSION INDUCES A DEFICIT IN WHITE MATTER FUNCTION THAT IS ATTENUATED BY MODULATING MICROGLIA WITH DIMETHYL FUMARATE

Autor: Fowler, Jill Helen, McQueen, Jamie, Holland, Philip R., Manso, Yasmina, Marangoni, Martina, Scott, Fiona, Chisholm, Emma, Scannevin, Robert, Hardingham, Giles, Horsburgh, Karen

Publikováno v: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2017 13(7) Supplement:P1302-P1303