Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Chisato Kunitomi"'
Autor:
Akari Kusamoto, Miyuki Harada, Ayaka Minemura, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Nanoka Sakaguchi, Jerilee M. K. Azhary, Hiroshi Koike, Zixin Xu, Tsurugi Tanaka, Yoko Urata, Chisato Kunitomi, Nozomi Takahashi, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The gut microbiome is implicated in the pathogenesis of polycystic ovary syndrome (PCOS), and prenatal androgen exposure is involved in the development of PCOS in later life. Our previous study of a mouse model of PCOS induced by prenatal dihydrotest
Externí odkaz:
https://doaj.org/article/90b5c734052349d09fdd929a2b8053ed
Autor:
Zixin Xu, Nozomi Takahashi, Miyuki Harada, Chisato Kunitomi, Akari Kusamoto, Hiroshi Koike, Tsurugi Tanaka, Nanoka Sakaguchi, Yoko Urata, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17193 (2023)
Young female cancer patients can develop chemotherapy-induced primary ovarian insufficiency (POI). Cyclophosphamide (Cy) is one of the most widely used chemotherapies and has the highest risk of damaging the ovaries. Recent studies elucidated the piv
Externí odkaz:
https://doaj.org/article/5b81eeecfffb4dfe90dfd6c5fc5ef536
Autor:
Hiroshi Koike, Miyuki Harada, Akari Kusamoto, Zixin Xu, Tsurugi Tanaka, Nanoka Sakaguchi, Chisato Kunitomi, Jerilee M. K. Azhary, Nozomi Takahashi, Yoko Urata, Yutaka Osuga
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-age women, affecting up to 15% of women in this group, and the most common cause of anovulatory infertility. Although its etiology remains unclear, recent resea
Externí odkaz:
https://doaj.org/article/78254a89a6ed46cda49a8549473da9a6
Autor:
Chisato Kunitomi, Miyuki Harada, Yuko Sanada, Akari Kusamoto, Yasushi Takai, Tatsuro Furui, Yuko Kitagawa, Mitsutoshi Yamada, Chie Watanabe, Koichiro Tsugawa, Hiroyuki Nishiyama, Hajime Hosoi, Mitsuru Miyachi, Kazuhiko Sugiyama, Yoshinobu Maeda, Akira Kawai, Toshio Hamatani, Keishi Fujio, Nao Suzuki, Yutaka Osuga
Publikováno v:
Reproductive Medicine and Biology, Vol 21, Iss 1, Pp n/a-n/a (2022)
Abstract Purpose In 2017, the first guidelines for fertility preservation in cancer patients were published in Japan. However, the impact of the guidelines remains unknown. Therefore, the authors conducted a nationwide survey on cryopreservation proc
Externí odkaz:
https://doaj.org/article/30e1ddd92d2345a594902258c6f28f4b
Autor:
Hiroshi Koike, Miyuki Harada, Akari Kusamoto, Chisato Kunitomi, Zixin Xu, Tsurugi Tanaka, Yoko Urata, Emi Nose, Nozomi Takahashi, Osamu Wada-Hiraike, Yasushi Hirota, Kaori Koga, Yutaka Osuga
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1037 (2022)
Endoplasmic reticulum (ER) stress activated in granulosa cells contributes to the pathophysiology of polycystic ovary syndrome (PCOS). In addition, recent studies have demonstrated that Notch signaling plays multiple roles in the ovary via cell-to-ce
Externí odkaz:
https://doaj.org/article/e1a80321abd14e4882d8719f65827c56
Autor:
Nozomi Takahashi, Miyuki Harada, Yasushi Hirota, Emi Nose, Jerilee MK Azhary, Hiroshi Koike, Chisato Kunitomi, Osamu Yoshino, Gentaro Izumi, Tetsuya Hirata, Kaori Koga, Osamu Wada-Hiraike, R. Jeffrey Chang, Shunichi Shimasaki, Tomoyuki Fujii, Yutaka Osuga
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Recent studies report the involvement of intra-ovarian factors, such as inflammation and oxidative stress, in the pathophysiology of polycystic ovary syndrome (PCOS), the most common endocrine disorder of reproductive age women. Endoplasmic
Externí odkaz:
https://doaj.org/article/a896312441f14824ba86b094670a2d29
Autor:
Chisato Kunitomi, Miyuki Harada, Yuko Sanada, Akari Kusamoto, Yasushi Takai, Tatsuro Furui, Yuko Kitagawa, Mitsutoshi Yamada, Chie Watanabe, Koichiro Tsugawa, Hiroyuki Nishiyama, Hajime Hosoi, Mitsuru Miyachi, Kazuhiko Sugiyama, Yoshinobu Maeda, Akira Kawai, Toshio Hamatani, Keishi Fujio, Nao Suzuki, Yutaka Osuga
Publikováno v:
Reproductive medicine and biology. 21(1)
In 2017, the first guidelines for fertility preservation in cancer patients were published in Japan. However, the impact of the guidelines remains unknown. Therefore, the authors conducted a nationwide survey on cryopreservation procedures in the per
Autor:
Akari Kusamoto, Miyuki Harada, Jerilee Mariam Khong, Chisato Kunitomi, Hiroshi Koike, Osamu Hiraike, Yutaka Osuga
Publikováno v:
Journal of the Endocrine Society. 6:A713-A713
PCOS is a complex multigenic disorder with strong epigenetic and environmental influence. Previous reports have suggested that fetal over-exposure to androgens contributes to the development of PCOS after birth. On the other hands, recent studies on
Autor:
Tomoyuki Fujii, Zixin Xu, Yoko Urata, Osamu Wada-Hiraike, Jerilee M K Azhary, Chisato Kunitomi, Emi Nose, Tetsuaki Kaku, Akari Kusamoto, Yutaka Osuga, Miyuki Harada, Nozomi Takahashi, Kaori Koga, Hiroshi Koike, Yasushi Hirota
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(11)
It has been recently recognized that prenatal androgen exposure is involved in the development of polycystic ovary syndrome (PCOS) in adulthood. In addition, the gut microbiome in adult patients and rodents with PCOS differs from that of healthy indi
Autor:
Osamu Wada-Hiraike, Yutaka Osuga, Tetsuya Hirata, Jerilee M K Azhary, Tomoyuki Fujii, Emi Nose, Chisato Kunitomi, Hiromi Terao, Kaori Koga, Nozomi Takahashi, Hiroshi Koike, Yasushi Hirota, Miyuki Harada
Publikováno v:
Molecular Human Reproduction. 25:684-694
Advanced glycation end products (AGEs) affect the follicular microenvironment. The close relationship between AGEs, proinflammatory cytokine production and activation of the unfolded protein response (UPR), which involves activating transcription fac