Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chisato Kinoshita"'
Publikováno v:
Antioxidants, Vol 13, Iss 7, p 771 (2024)
Erythroid differentiation regulator 1 (Erdr1) is a cytokine known to play important roles in cell survival under stressful conditions, maintenance of cellular growth homeostasis, and activation of the immune system. However, the impact of Erdr1 on ne
Externí odkaz:
https://doaj.org/article/2bbc30a9511a4bc7a7667ec626c7691e
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 1, Pp 37-45 (2023)
Purine derivatives such as caffeine and uric acid have neuroprotective activities and are negatively correlated with the incidence of both Alzheimer's disease and Parkinson's disease. We have reported that an increment of intracellular glutathione (G
Externí odkaz:
https://doaj.org/article/2a5341b0b0114d75965930f3d11cffda
Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
Autor:
Chisato Kinoshita, Kazue Kikuchi-Utsumi, Koji Aoyama, Ryo Suzuki, Yayoi Okamoto, Nobuko Matsumura, Daiki Omata, Kazuo Maruyama, Toshio Nakaki
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Chisato Kinoshita et al. use a microbubble and ultrasound delivery system to inhibit miR-96-5p in the mouse brain. They demonstrate that miR96-5p regulates glutathione levels through the NOVA1 RNA binding protein, suggesting that this microRNA could
Externí odkaz:
https://doaj.org/article/4ec843332a5e4a27be302abc87f8c949
Publikováno v:
Clocks & Sleep, Vol 2, Iss 3, Pp 282-307 (2020)
Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcriptio
Externí odkaz:
https://doaj.org/article/c6a6ddb74a39476cb95cbe05b008c431
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15076 (2022)
Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by parkinsonism, cerebellar impairment, and autonomic failure. Although the causes of MSA onset and progression remain uncertain, its pathogenesis may involve oxidative s
Externí odkaz:
https://doaj.org/article/0b78e5af967a444d90aaddac729cf107
Autor:
Akiyo Yatagai, Chisato Kinoshita
Publikováno v:
Atmosphere, Vol 13, Iss 9, p 1413 (2022)
The effect of global climate change on the distribution of snow water is a great concern. Thus, it is important to clarify the characteristics of winter precipitation variability, including mountain precipitation, together with climate indices. In th
Externí odkaz:
https://doaj.org/article/911e135414c543e0a4dd49556cb93706
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5292 (2021)
The number of patients with neurodegenerative diseases (NDs) is increasing, along with the growing number of older adults. This escalation threatens to create a medical and social crisis. NDs include a large spectrum of heterogeneous and multifactori
Externí odkaz:
https://doaj.org/article/7fe424883bb9451a8685188d77098e9a
Autor:
Chisato Kinoshita, Koji Aoyama
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4245 (2021)
The establishment of antioxidative defense systems might have been mandatory for most living beings with aerobic metabolisms, because oxygen consumption produces adverse byproducts known as reactive oxygen species (ROS). The brain is especially vulne
Externí odkaz:
https://doaj.org/article/2726752bc69c4ae09c3f11af93836bee
Publikováno v:
AIMS Molecular Science, Vol 2, Iss 2, Pp 124-143 (2015)
microRNA (miRNA) is a small non-coding RNA molecule that plays a role in the post-transcriptional regulation of gene expression. Recent evidence shows that miRNAs are involved in various diseases, including neurodegenerative diseases (NDs) such as: P
Externí odkaz:
https://doaj.org/article/cfb6bf014eea40be80c6361eba263426
Autor:
Koji Aoyama, Fan Wang, Nobuko Matsumura, Hiroshi Kiyonari, Go Shioi, Karo Tanaka, Chisato Kinoshita, Kazue Kikuchi-Utsumi, Masahiko Watabe, Toshio Nakaki
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 973-982 (2012)
Glutathione (GSH) is an important neuroprotective molecule in the brain. The strategy to increase neuronal GSH level is a promising approach to the treatment of neurodegenerative diseases. However, the regulatory mechanism by which neuron-specific GS
Externí odkaz:
https://doaj.org/article/f1b642bed8a341b693c32f1525daa974